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0 0.5 1 1.5 2+ Progression -26% Improvement Relative Risk Andrographolide  Tanwettiyanont et al.  LATE TREATMENT Is late treatment with andrographolide beneficial for COVID-19? Retrospective 605 patients in Thailand (March 2020 - August 2021) Higher progression with andrographolide (not stat. sig., p=0.4) Tanwettiyanont et al., Frontiers in Me.., Aug 2022 Favors andrographolide Favors control

Use of Andrographis paniculata (Burm.f.) Wall. ex Nees and risk of pneumonia in hospitalised patients with mild coronavirus disease 2019: A retrospective cohort study

Tanwettiyanont et al., Frontiers in Medicine, doi:10.3389/fmed.2022.947373
Aug 2022  
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Retrospective 605 hospitalized patients in Thailand, showing higher progression with andrographis, without statistical significance.
risk of progression, 26.0% higher, HR 1.26, p = 0.40, treatment 37 of 351 (10.5%), control 22 of 254 (8.7%), Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tanwettiyanont et al., 10 Aug 2022, retrospective, Thailand, peer-reviewed, mean age 35.4, 8 authors, study period 1 March, 2020 - 31 August, 2021. Contact:,
This PaperAndrographol..All
Use of Andrographis paniculata (Burm.f.) Wall. ex Nees and risk of pneumonia in hospitalised patients with mild coronavirus disease 2019: A retrospective cohort study
Jeeranan Tanwettiyanont, Napacha Piriyachananusorn, Lilit Sangsoi, Benjawan Boonsong, Chamlong Sunpapoa, Patcharawan Tanamatayarat, Nat Na-Ek, Sukrit Kanchanasurakit
Frontiers in Medicine, doi:10.3389/fmed.2022.947373
Background: Andrographis paniculata (Burm.f.) Wall. ex Nees (AP) has been widely used in Thailand to treat mild COVID-19 infections since early 2020; however, supporting evidence is scarce and ambiguous. Thus, this study aimed to examine whether the use of AP is associated with a decreased risk of pneumonia in hospitalised mild COVID-19 patients. Materials and methods: We collected data between March 2020 and August 2021 from COVID-19 patients admitted to one hospital in Thailand. Patients whose infection was confirmed by real-time polymerase chain reaction, had normal chest radiography and did not receive favipiravir at admission were included and categorised as either AP (deriving from a dried and ground aerial part of the plant), given as capsules with a total daily dose of 180 mg andrographolide for 5 days or standard of care. They were followed for pneumonia confirmed by chest radiography. Multiple logistic regression was used for the analysis controlling for age, sex, diabetes, hypertension, statin use, and antihypertensive drug use.
Ethics statement The studies involving human participants were reviewed and approved by the Ethical Committee for clinical research of Phrae Hospital approved this study (no. 70/2564). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. Author contributions JT, SK, and NN-E conceptualised the study objectives, designed and collected the data, contributed to the literature review, data cleaning, data analyses, and interpretation of the findings. JT prepared an initial manuscript. NN-E further developed subsequent manuscripts. SK, PT, NP, LS, BB, and CS critically revised the initial manuscript. All authors contributed to manuscript revision, read, and approved the submitted version. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary Material for this article can be found online at:
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Late treatment
is less effective
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