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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality -200% Improvement Relative Risk Mortality (b) 60% Progression 45% Progression (b) 50% Casirivimab/i..  Suzuki et al.  EARLY TREATMENT Is early treatment with casirivimab/imdevimab beneficial for COVID-19? Retrospective 949 patients in Japan (July - September 2021) Lower progression with casirivimab/imdevimab (p=0.021) c19early.org Suzuki et al., medRxiv, December 2021 Favors casirivimab/im.. Favors control

Real-world clinical outcomes of treatment with casirivimab-imdevimab among patients with mild-to-moderate coronavirus disease 2019 during the Delta variant pandemic

Suzuki et al., medRxiv, doi:10.1101/2021.12.19.21268078
Dec 2021  
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16th treatment shown to reduce risk in March 2021
 
*, now known with p = 0.000018 from 28 studies, recognized in 42 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 949 patients in Japan, 314 treated with casirivimab/imdevimab showing significantly lower risk of deterioration with treatment.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants Haars, Liu, Pochtovyi, Sheward, Tatham, VanBlargan.
risk of death, 200.0% higher, RR 3.00, p = 1.00, treatment 1 of 222 (0.5%), control 0 of 222 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), propensity score matching.
risk of death, 59.6% lower, RR 0.40, p = 0.67, treatment 1 of 314 (0.3%), control 5 of 635 (0.8%), NNT 213, unadjusted.
risk of progression, 45.2% lower, RR 0.55, p = 0.02, treatment 17 of 222 (7.7%), control 31 of 222 (14.0%), NNT 16, propensity score matching.
risk of progression, 49.9% lower, RR 0.50, p = 0.002, treatment 34 of 314 (10.8%), control 70 of 365 (19.2%), NNT 12, odds ratio converted to relative risk, multivariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Suzuki et al., 21 Dec 2021, retrospective, Japan, preprint, 49 authors, study period 24 July, 2021 - 30 September, 2021. Contact: shibatay@fmu.ac.jp.
This PaperCasirivimab/i..All
Real-world clinical outcomes of treatment with casirivimab-imdevimab among patients with mild-to-moderate coronavirus disease 2019 during the Delta variant pandemic
Yasuhito Suzuki, MD Yoko Shibata, Hiroyuki Minemura, Takefumi Nikaido, Yoshinori Tanino, Atsuro Fukuhara, Ryuzo Kanno, Hiroyuki Saito, Shuzo Suzuki, Taeko Ishii, Yayoi Inokoshi, Eiichiro Sando, Hirofumi Sakuma, Tatsuho Kobayashi, Hiroaki Kume, Masahiro Kamimoto, Hideko Aoki, Akira Takama, Takamichi Kamiyama, Masaru Nakayama, Kiyoshi Saito, Koichi Tanigawa, Masahiko Sato, Toshiyuki Kanbe, Norio Kanzaki, Teruhisa Azuma, Keiji Sakamoto, Yuichi Nakamura, Hiroshi Otani, Mitsuru Waragai, Shinsaku Maeda, Tokiya Ishida, Keishi Sugino, Yasuhiko Tsukada, Ryuki Yamada, Riko Sato, Takumi Omuna, Hikaru Tomita, Mikako Saito, Natsumi Watanabe, Mami Rikimaru, Takaya Kawamata, Takashi Umeda, Julia Morimoto, Ryuichi Togawa, Yuki Sato, Junpei Saito, Kenya Kanazawa, Ken Iseki
doi:10.1101/2021.12.19.21268078
This real-world retrospective study demonstrates the contribution of treatment with casirivimab-imdevimab to the prevention of deterioration in patients with mild-to-All rights reserved. No reuse allowed without permission. perpetuity.
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{ 'DOI': '10.1101/2021.12.19.21268078', 'URL': 'http://dx.doi.org/10.1101/2021.12.19.21268078', 'abstract': '<jats:p>Background: Mutations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ' 'may reduce the efficacy of neutralizing monoclonal antibody therapy against coronavirus ' 'disease 2019 (COVID-19). We here evaluated the efficacy of casirivimab-imdevimab in patients ' 'with mild-to-moderate COVID-19 during the Delta variant surge in Fukushima Prefecture, ' 'Japan.\n' 'Methods: We enrolled 949 patients with mild-to-moderate COVID-19 who were admitted to ' 'hospital between July 24, 2021 and September 30, 2021. Clinical deterioration after admission ' 'was compared between casirivimab-imdevimab users (n = 314) and non-users (n = 635). \n' 'Results: The casirivimab-imdevimab users were older (P &lt; 0.0001), had higher body ' 'temperature (≥ 38 degree) (P &lt; 0.0001) and greater rates of history of cigarette smoking ' '(P = 0.0068), hypertension (P = 0.0004), obesity (P &lt; 0.0001), and dyslipidemia (P &lt; ' '0.0001) than the non-users. Multivariate logistic regression analysis demonstrated that ' 'receiving casirivimab-imdevimab was an independent factor for preventing deterioration (odds ' 'ratio 0.448; 95% confidence interval 0.263 to 0.763; P = 0.0023). Furthermore, in 222 ' 'patients who were selected from each group after matching on the propensity score, ' 'deterioration was significantly lower among those receiving casirivimab-imdevimab compared to ' 'those not receiving casirivimab-imdevimab (7.66% vs 14.0%; p = 0.021).\n' 'Conclusion: This real-world study demonstrates that casirivimab-imdevimab contributes to the ' 'prevention of deterioration in COVID-19 patients after hospitalization during a Delta variant ' 'surge.</jats:p>', 'accepted': {'date-parts': [[2021, 12, 21]]}, 'author': [ {'affiliation': [], 'family': 'Suzuki', 'given': 'Yasuhito', 'sequence': 'first'}, {'affiliation': [], 'family': 'Shibata', 'given': 'Yoko', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Minemura', 'given': 'Hiroyuki', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Nikaido', 'given': 'Takehumi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Tanino', 'given': 'Yoshinori', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Fukuhara', 'given': 'Atsuro', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kanno', 'given': 'Ryuzo', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Saito', 'given': 'Hiroyuki', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Suzuki', 'given': 'Shuzo', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ishii', 'given': 'Taeko', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Inokoshi', 'given': 'Yayoi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Sando', 'given': 'Eiichiro', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Sakuma', 'given': 'Hirofumi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kobayashi', 'given': 'Tatsuho', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kume', 'given': 'Hiroaki', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kamimoto', 'given': 'Masahiro', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Aoki', 'given': 'Hideko', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Takama', 'given': 'Akira', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kamiyama', 'given': 'Takamichi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Nakayama', 'given': 'Masaru', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Saito', 'given': 'Kiyoshi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Tanigawa', 'given': 'Koichi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Sato', 'given': 'Masahiko', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kanbe', 'given': 'Toshiyuki', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kanzaki', 'given': 'Norio', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Azuma', 'given': 'Teruhisa', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Sakamoto', 'given': 'Keiji', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Nakamura', 'given': 'Yuichi', 'sequence': 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'Watanabe', 'given': 'Natsumi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Rikimaru', 'given': 'Mami', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kawamata', 'given': 'Takaya', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Umeda', 'given': 'Takashi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Morimoto', 'given': 'Julia', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Togawa', 'given': 'Ryuichi', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Sato', 'given': 'Yuki', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Saito', 'given': 'Junpei', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Kanazawa', 'given': 'Kenya', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Iseki', 'given': 'Ken', 'sequence': 'additional'}], 'container-title': [], 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': { 'date-parts': [[2021, 12, 22]], 'date-time': '2021-12-22T03:45:14Z', 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