Antiviral Intervention of COVID-19: Linkage of Disease Severity with Genetic Markers FGB (rs1800790), NOS3 (rs2070744) and TMPRSS2 (rs12329760)

DOI record: { "DOI": "10.3390/v17060792", "ISSN": [ "1999-4915" ], "URL": "http://dx.doi.org/10.3390/v17060792", "abstract": "<jats:p>The purpose of this study was to investigate polymorphic variants of the genes FGB (rs1800790), NOS3 (rs2070744) and TMPRSS2 (rs12329760) in patients with SARS-CoV-2 and to determine their role in the COVID-19 severity course against the background of antiviral therapy. Real-time polymerase chain reaction (RT-PCR) was used to genotype the polymorphism of the selected genes. GS-5734 (remdesivir) was prescribed as the basic antiviral drug. Binary logistic regression confirmed a low probability of COVID-19 developing in carriers of the A-allele of the FGB gene. The highest probability of moderate and severe COVID-19 clinical forms developing was found in G-allele carriers (especially the GG genotype) of the FGB gene (rs1800790) and the T-allele of the TMPRSS2 gene (rs12329760). Antiviral drug GS-5734 (remdesivir) administration with anti-inflammatory therapy reduces the TMPRSS2 blood level in moderate COVID-19, IL-6 in severe COVID-19 course, and fibrinogen A- and D-dimers in both groups. The proposed treatment does not significantly affect the concentration of endothelin-1, but a decrease in procalcitonin associated with additional antibacterial use was observed, especially in severe COVID-19.</jats:p>", "alternative-id": [ "v17060792" ], "author": [ { "ORCID": "https://orcid.org/0000-0002-7150-7146", "affiliation": [ { "name": "Department of Infectious Diseases and Epidemiology, Bukovinian State Medical University, 58012 Chernivtsi, Ukraine" } ], "authenticated-orcid": false, "family": "Sokolenko", "given": "Maksym", "sequence": "first" }, { "ORCID": "https://orcid.org/0000-0001-9279-9531", "affiliation": [ { "name": "Department of Family Medicine, Bukovinian State Medical University, 58012 Chernivtsi, Ukraine" } ], "authenticated-orcid": false, "family": "Sydorchuk", "given": "Larysa", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Family Medicine, Bukovinian State Medical University, 58012 Chernivtsi, Ukraine" } ], "family": "Sokolenko", "given": "Alina", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0002-3603-3432", "affiliation": [ { "name": "Department of Surgery No 2, Bukovinian State Medical University, 58012 Chernivtsi, Ukraine" } ], "authenticated-orcid": false, "family": "Sydorchuk", "given": "Ruslan", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0002-4483-1856", "affiliation": [ { "name": "Department of Medical Rehabilitation, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine" } ], "authenticated-orcid": false, "family": "Kamyshna", "given": "Iryna", "sequence": "additional" }, { "affiliation": [ { "name": "Donauklinik, 89231 Neu Ulm, Germany" } ], "family": "Sydorchuk", "given": "Andriy", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Medical and Biological Fundamentals of Physical Culture, Pavlo Tychyna Uman State Pedagogical University, 20300 Uman, Ukraine" } ], "family": "Sokolenko", "given": "Ludmila", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Infectious Diseases, Bukovinian State Medical University, 58012 Chernivtsi, Ukraine" } ], "family": "Sokolenko", "given": "Oleksandr", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0002-5088-3791", "affiliation": [ { "name": "Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway" } ], "authenticated-orcid": false, "family": "Oksenych", "given": "Valentyn", "sequence": "additional" }, { "ORCID": "https://orcid.org/0000-0003-3141-4436", "affiliation": [ { "name": "Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine" } ], "authenticated-orcid": false, "family": "Kamyshnyi", "given": "Oleksandr", "sequence": "additional" } ], "container-title": "Viruses", "container-title-short": "Viruses", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2025, 5, 30 ] ], "date-time": "2025-05-30T12:07:58Z", "timestamp": 1748606878000 }, "deposited": { "date-parts": [ [ 2025, 5, 30 ] ], "date-time": "2025-05-30T12:13:05Z", "timestamp": 1748607185000 }, "funder": [ { "award": [ "#36" ], "name": "CSMC Senior Scientists" } ], "indexed": { "date-parts": [ [ 2025, 5, 31 ] ], "date-time": "2025-05-31T04:07:42Z", "timestamp": 1748664462079, "version": "3.41.0" }, "is-referenced-by-count": 0, "issue": "6", "issued": { "date-parts": [ [ 2025, 5, 30 ] ] }, "journal-issue": { "issue": "6", "published-online": { "date-parts": [ [ 2025, 6 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 5, 30 ] ], "date-time": "2025-05-30T00:00:00Z", "timestamp": 1748563200000 } } ], "link": [ { "URL": "https://www.mdpi.com/1999-4915/17/6/792/pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1968", "original-title": [], "page": "792", "prefix": "10.3390", "published": { "date-parts": [ [ 2025, 5, 30 ] ] }, "published-online": { "date-parts": [ [ 2025, 5, 30 ] ] }, "publisher": "MDPI AG", "reference": [ { "DOI": "10.1186/s40246-020-00280-6", "article-title": "Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): Rapid systematic review and field synopsis", "author": "Latini", "doi-asserted-by": "crossref", "first-page": "30", "journal-title": "Hum. 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