Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial

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Med", "key": "10.1016/j.ijid.2021.04.035_bib0060", "volume": "77", "year": "2020" }, { "DOI": "10.1093/jtm/taaa039", "article-title": "Interrupting transmission of COVID-19: lessons from containment efforts in Singapore", "author": "Lee", "doi-asserted-by": "crossref", "journal-title": "J Travel Med", "key": "10.1016/j.ijid.2021.04.035_bib0065", "volume": "27", "year": "2020" }, { "DOI": "10.47102/annals-acadmedsg.2020257", "article-title": "Comparative analysis of symptomatic and asymptomatic SARS-CoV-2 infection in children", "author": "Li", "doi-asserted-by": "crossref", "first-page": "530", "journal-title": "Ann Acad Med Singap", "key": "10.1016/j.ijid.2021.04.035_bib0070", "year": "2020" }, { "DOI": "10.1038/s41421-020-0156-0", "article-title": "Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro", "author": "Liu", "doi-asserted-by": "crossref", "first-page": "16", "journal-title": "Cell Discov", "key": "10.1016/j.ijid.2021.04.035_bib0075", "volume": "6", "year": "2020" }, { "DOI": "10.1038/s41586-020-2558-4", "article-title": "Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates", "author": "Maisonnasse", "doi-asserted-by": "crossref", "first-page": "584", "journal-title": "Nature", "key": "10.1016/j.ijid.2021.04.035_bib0080", "volume": "585", "year": "2020" }, { "article-title": "RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis", "author": "Mehra", "journal-title": "Lancet", "key": "10.1016/j.ijid.2021.04.035_bib0085", "year": "2020" }, { "DOI": "10.1056/NEJMoa2021801", "article-title": "A cluster-randomized trial of hydroxychloroquine for prevention of Covid-19", "author": "Mitjà", "doi-asserted-by": "crossref", "first-page": "417", "journal-title": "N Engl J Med", "key": "10.1016/j.ijid.2021.04.035_bib0090", "volume": "384", "year": "2020" }, { "DOI": "10.1016/j.ijid.2020.08.076", "article-title": "Asymptomatic SARS Coronavirus 2 infection: invisible yet invincible", "author": "Nikolai", "doi-asserted-by": "crossref", "first-page": "112", "journal-title": "Int J Infect Dis", "key": "10.1016/j.ijid.2021.04.035_bib0095", "volume": "100", "year": "2020" }, { "author": "R Core Team", "key": "10.1016/j.ijid.2021.04.035_bib0100", "series-title": "R: A language and environment for statistical computing", "year": "2020" }, { "DOI": "10.1093/jtm/taab005", "article-title": "From hydroxychloroquine to ivermectin: what are the anti-viral properties of anti-parasitic drugs to combat SARS-CoV-2?", "author": "Rakedzon", "doi-asserted-by": "crossref", "journal-title": "J Travel Med", "key": "10.1016/j.ijid.2021.04.035_bib0105", "year": "2021" }, { "DOI": "10.1001/jama.2020.8630", "article-title": "Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State", "author": "Rosenberg", "doi-asserted-by": "crossref", "first-page": "2493", "journal-title": "JAMA", "key": "10.1016/j.ijid.2021.04.035_bib0110", "volume": "323", "year": "2020" }, { "key": "10.1016/j.ijid.2021.04.035_bib0115", "unstructured": "Singapore Ministry of Health 2020. https://www.moh.gov.sg/covid-19 [Accessed 5 March 2021]." }, { "DOI": "10.1136/openhrt-2020-001362", "article-title": "Hydroxychloroquine use in COVID-19: is the risk of cardiovascular toxicity justified?", "author": "Stevenson", "doi-asserted-by": "crossref", "journal-title": "Open Heart", "key": "10.1016/j.ijid.2021.04.035_bib0120", "volume": "7", "year": "2020" }, { "DOI": "10.1093/cid/ciaa322", "article-title": "Epidemiological and clinical predictors of COVID-19", "author": "Sun", "doi-asserted-by": "crossref", "first-page": "786", "journal-title": "Clin Infect Dis", "key": "10.1016/j.ijid.2021.04.035_bib0125", "volume": "71", "year": "2020" }, { "DOI": "10.3390/ijerph18010252", "article-title": "Singapore’s pandemic preparedness: an overview of the first wave of COVID-19", "author": "Tan", "doi-asserted-by": "crossref", "first-page": "252", "journal-title": "Int J Environ Res Public Health", "key": "10.1016/j.ijid.2021.04.035_bib0130", "volume": "18", "year": "2020" }, { "DOI": "10.47102/annals-acadmedsg.2020306", "article-title": "Coronavirus disease 2019 (COVID-19): the Singapore Experience. A review of the first eight months", "author": "Tan", "doi-asserted-by": "crossref", "first-page": "764", "journal-title": "Ann Acad Med Singap", "key": "10.1016/j.ijid.2021.04.035_bib0135", "volume": "49", "year": "2020" }, { "DOI": "10.1371/journal.ppat.1001176", "article-title": "Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture", "author": "te Velthuis", "doi-asserted-by": "crossref", "journal-title": "PLoS Pathog", "key": "10.1016/j.ijid.2021.04.035_bib0140", "volume": "6", "year": "2010" }, { "DOI": "10.18821/0869-2084-2020-65-12-785-792", "article-title": "Detection of SARS-CoV-2 RNA in nasopharyngeal swabs from COVID-19 patients and asymptomatic cases of infection by real-time and digital PCR", "author": "Ternovoi", "doi-asserted-by": "crossref", "first-page": "785", "journal-title": "Klin Lab Diagn", "key": "10.1016/j.ijid.2021.04.035_bib0145", "volume": "65", "year": "2020" }, { "DOI": "10.1001/jama.2020.12839", "article-title": "Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review", "author": "Wiersinga", "doi-asserted-by": "crossref", "first-page": "782", "journal-title": "JAMA", "key": "10.1016/j.ijid.2021.04.035_bib0150", "volume": "324", "year": "2020" }, { "DOI": "10.1093/cid/ciaa237", "article-title": "In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)", "author": "Yao", "doi-asserted-by": "crossref", "first-page": "732", "journal-title": "Clin Infect Dis", "key": "10.1016/j.ijid.2021.04.035_bib0155", "volume": "71", "year": "2020" }, { "article-title": "Health equity considerations in COVID-19: geospatial network analysis of the COVID-19 outbreak in the migrant population in Singapore", "author": "Yi", "journal-title": "J Travel Med", "key": "10.1016/j.ijid.2021.04.035_bib0160", "year": "2020" }, { "article-title": "Viral dynamics and immune correlates of COVID-19 disease severity", "author": "Young", "journal-title": "Clin Infect Dis", "key": "10.1016/j.ijid.2021.04.035_bib0165", "year": "2020" } ], "reference-count": 33, "references-count": 33, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1201971221003453" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Infectious Diseases", "Microbiology (medical)", "General Medicine" ], "subtitle": [], "title": "Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: An open-label randomized trial", "type": "journal-article", "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy", "volume": "106" }