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Safety Profile of Molnupiravir in the Treatment of COVID-19: A Descriptive Study Based on FAERS Data

Santi Laurini et al., Journal of Clinical Medicine, doi:10.3390/jcm12010034
Dec 2022  
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Safety analysis of molnupiravir reporting an unexpectedly high rate of serious adverse reactions.
Santi Laurini et al., 21 Dec 2022, Italy, peer-reviewed, survey, 3 authors. Contact: domenico.motola@unibo.it (corresponding author).
This PaperMolnupiravirAll
Safety Profile of Molnupiravir in the Treatment of COVID-19: A Descriptive Study Based on FAERS Data
Antonio C P Wong, Susanna K P Lau, Greta Santi Laurini, Nicola Montanaro, Domenico Motola
doi:10.3390/jcm12010034
Concerns have been raised about the actual benefit and safety of molnupiravir, a new antiviral treatment for coronavirus disease 2019 . In order to provide additional evidence to support its use, we aimed to evaluate the real safety profile based on post-marketing pharmacovigilance data. Molnupiravir safety data were captured from the FDA Adverse Event Reporting System (FAERS). We performed a descriptive analysis of the baseline demographic characteristics of patients who experienced at least one adverse drug reaction (ADRs) related to molnupiravir, and then evaluated those most frequently reported. As of 31 March 2022, 612 reports of ADRs related to molnupiravir were submitted to the FDA, 301 (49.18%) were related to females and 281 (45.92%) to males. Most reports (524; 85.62%) were submitted by healthcare professionals and 345 (56.37%) concerned serious outcomes. The most common reported ADRs were diarrhoea (57; 4.51%), rash (36; 2.85), nausea (29; 2.30%), and COVID-19 pneumonia (22; 1.74%). The most frequent adverse reactions reported with molnupiravir in the U.S. post-marketing experience are consistent with the safety evaluation of the antiviral medicine. Even if no evident safety concerns emerged, an unexpectedly high rate of serious adverse reactions together with a few cases of potential new adverse reactions occurred.
Institutional Review Board Statement: Not applicable. Informed Consent Statement: Not applicable. Conflicts of Interest: The authors declare no conflict of interest.
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Chemother.'}], 'container-title': 'Journal of Clinical Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/2077-0383/12/1/34/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 12, 23]], 'date-time': '2022-12-23T09:33:52Z', 'timestamp': 1671788032000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/2077-0383/12/1/34'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 12, 21]]}, 'references-count': 41, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2023, 1]]}}, 'alternative-id': ['jcm12010034'], 'URL': 'http://dx.doi.org/10.3390/jcm12010034', 'relation': {}, 'ISSN': ['2077-0383'], 'subject': ['General Medicine'], 'container-title-short': 'JCM', 'published': {'date-parts': [[2022, 12, 21]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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