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@CovidAnalysis
All Studies   All Outcomes    Recent:   

An International, Multicenter, Randomized, Double-blind, Adaptive Placebo-controlled Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe SARS-CoV-2 Infection (COVID-19)

Samsonov et al., NCT04380519, NCT04380519
Jan 2022  
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Mortality -135% Improvement Relative Risk Improvement 2+ points 0% Improvement 1+ points 3% Goflikicept  Samsonov et al.  LATE TREATMENT  DB RCT Is late treatment with goflikicept beneficial for COVID-19? Double-blind RCT 248 patients in Russia Higher mortality with goflikicept (not stat. sig., p=0.066) c19early.org Samsonov et al., NCT04380519, January 2022 Favorsgoflikicept Favorscontrol 0 0.5 1 1.5 2+
RCT 248 hospitalized patients showing higher mortality (p=0.07) with goflikicept (RPH-104).
Important missing comments or errors? Let us know.
risk of death, 135.2% higher, RR 2.35, p = 0.07, treatment 14 of 123 (11.4%), control 6 of 124 (4.8%), day 29.
risk of no improvement 2+ points, no change, RR 1.00, p = 1.00, treatment 30 of 124 (24.2%), control 30 of 124 (24.2%), day 29.
risk of no improvement 1+ points, 2.7% lower, RR 0.97, p = 1.00, treatment 36 of 124 (29.0%), control 37 of 124 (29.8%), NNT 124, day 29.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Samsonov et al., 24 Jan 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Russia, preprint, 1 author, trial NCT04380519 (history). Contact: sa.grishin@rpharm.ru.
This PaperGoflikiceptAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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