Conv. Plasma
Nigella Sativa

All famotidine studies
Meta analysis
study COVID-19 treatment researchFamotidineFamotidine (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Hospitalization time 33% Improvement Relative Risk Recovery 0% Recovery (b) 50% Famotidine  Samimagham et al.  LATE TREATMENT  RCT Is late treatment with famotidine beneficial for COVID-19? RCT 20 patients in Iran Shorter hospitalization with famotidine (p=0.04) Samimagham et al., Research Square, Apr 2021 Favors famotidine Favors control

The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A phase III randomised clinical trial

Samimagham et al., Research Square, doi:10.21203/
Apr 2021  
  Source   PDF   All   Meta
Famotidine for COVID-19
25th treatment shown to reduce risk in October 2021
*, now known with p = 0.00026 from 30 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments.
Very small RCT with 20 patients in Iran, showing shorter hospitalization time with famotidine treatment. There was no mortality or ICU admission. Famotidine 160mg four times a day. IRCT20200509047364N2.
hospitalization time, 33.3% lower, relative time 0.67, p = 0.04, treatment 10, control 10.
risk of no recovery, no change, RR 1.00, p = 1.00, treatment 5 of 10 (50.0%), control 5 of 10 (50.0%), >50% CT lung involvment.
risk of no recovery, 50.0% lower, RR 0.50, p = 0.37, treatment 3 of 10 (30.0%), control 6 of 10 (60.0%), NNT 3.3, no improvement in cough.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Samimagham et al., 27 Apr 2021, Single Blind Randomized Controlled Trial, placebo-controlled, Iran, preprint, 6 authors.
This PaperFamotidineAll
The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A phase III randomised clinical trial
Hamid Reza Samimagham, Mehdi Hassani Azad, Maryam Haddad, Mohsen Arabi, Dariush Hooshyar, Mitra Kazemijahromi
Introduction As the rst randomized clinical trial, this study evaluated the effect of Famotidine on the improvement of outcomes of hospitalized patients with COVID-19. Method This phase III randomized clinical trial was designed with two parallel arms, placebo-controlled, singleblind, and concealed allocation, and recruited 20 patients. Oral Famotidine 160 mg four times a day was given to patients until the discharge day or for a maximum of 14 days. Patients' temperature, respiration rate, oxygen saturation, lung in ltration, lactate dehydrogenase (LDH) level and complete blood count (CBC) were measured at the baseline (before the intervention) and on day 14 after the intervention or on discharge day. Length of stay in the hospital and length of stay in the ICU were also measured as secondary outcomes of the study. Results The results showed a signi cant decrease in LDH (P = 0.01), mean WBC (P = 0.04) and length of stay (P = 0.04) of patients with COVID-19 in the group treated with Famotidine compared to the control group. There was also a signi cant increase in oxygen saturation (P = 0.01) in the group treated with Famotidine compared to the control group. Cough improvement was also higher in the oral Famotidine group compared to the control group (P = 0.02). Conclusion This was the rst clinical trial on the effect of Famotidine on the improvement of hospitalized COVID-19 patients, which indicated that high-dose Famotidine improves patients' clinical signs and reduces the severity of the disease and duration of hospitalization.
Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. Supplementary Files This is a list of supplementary les associated with this preprint. Click to download. CONSORT2010Checklist.doc
Freedberg, Conigliaro, Wang, Tracey, Callahan M V et al., Famotidine Use is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study, Gastroenterology
Hogan, Hogan, Cannon, Rappi, Studdard et al., Dual-Histamine Blockade with Cetirizine -Famotidine Reduces Pulmonary Symptoms in COVID-19 Patients
Hu, Han, Zhang, Cao, Xie, Mast Cell-Induced Lung Injury in Mice Infected with H5N1 In uenza Virus, Journal of Virology
Janowitz, Gablenz, Pattinson, Wang, Conigliaro et al., Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series, Gut, doi:10.1136/gutjnl-2020-321852
Ji, Zhang, Xu, Chen, Ty-Ci, unde ned
Li, Xu, Yu, Wang, Tao et al., Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan, Journal of Allergy and Clinical Immunology
Loffredo, Lucero, Chen, Connell, Bergqvist et al., The Effect of Famotidine on SARS-CoV-2 Proteases and Virus Replication, bioRxiv, doi:10.1101/2020.07.15.203059
Malone, Tisdall, Smith, Liu, Huang et al., COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms, doi:10.21203/
Marshall, Portales-Cervantes, Leong, Mast Cell Responses to Viruses and Pathogen Products, International Journal of Molecular Sciences
Mo, Xing, Xiao, Deng, Zhao et al., Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, doi:10.1093/cid/ciaa270/5805508
Ortega, Serrano, Jastrzebska, Class A G Protein-Coupled Receptor Antagonist Famotidine as a Therapeutic Alternative against SARS-CoV2: An In Silico Analysis, Biomolecules
Samimagham, Azad, Haddad, Arabi, Hooshyar et al., The E cacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A structured summary of a study protocol for a randomised controlled trial
Sen Gupta, Biswal, Singha, Rana, Binding insight of clinically oriented drug famotidine with the identi ed potential target of SARS-CoV-2 [Internet, Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2020.1784795
Shaffer, 15 drugs being tested to treat COVID-19 and how they would work, Nature Medicine
Thangam, Jemima, Singh, Baig, Khan et al., The role of histamine and histamine receptors in mast cell-mediated allergy and in ammation: The hunt for new therapeutic targets
Wu, Liu, Yang, Zhang, Zhong et al., Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Pharmaceutica Sinica B
Zhao, Yao, Wang, Zheng, Gao et al., A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias
Zheng, Peng, Xu, Zhao, Liu et al., Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop