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Two-month period of 500 mg lecithin-based delivery form of quercetin daily dietary supplementation counterbalances chronic fatigue symptoms: A double-blind placebo controlled clinical trial

Rondanelli et al., Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2023.115453, NCT05730660
Nov 2023  
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Quercetin for COVID-19
24th treatment shown to reduce risk in July 2021, now with p = 0.002 from 12 studies.
No treatment is 100% effective. Protocols combine treatments.
5,200+ studies for 112 treatments. c19early.org
Double-blind placebo-controlled RCT of 78 subjects with chronic fatigue (27% due to long COVID) showing significant improvement in fatigue symptoms, sleep quality, physical activity, and short physical performance battery scores with 500 mg/day of a lecithin-based quercetin supplement (Quercetin Phytosome) for 2 months compared to placebo. All three domains of fatigue (cognitive, physical, psychosocial) were positively impacted. Authors hypothesize the reduction in fatigue allowed improvement in quality of life and physical activity.
Bioavailability. Quercetin has low bioavailability and studies typically use advanced formulations to improve bioavailability which may be required to reach therapeutic concentrations.
Rondanelli et al., 30 Nov 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Italy, peer-reviewed, mean age 56.0, 5 authors, trial NCT05730660 (history). Contact: clara.gasparri01@universitadipavia.it.
This PaperQuercetinAll
Two-month period of 500 mg lecithin-based delivery form of quercetin daily dietary supplementation counterbalances chronic fatigue symptoms: A double-blind placebo controlled clinical trial
Mariangela Rondanelli, Antonella Riva, Giovanna Petrangolini, Clara Gasparri, Simone Perna
Biomedicine & Pharmacotherapy, doi:10.1016/j.biopha.2023.115453
Background: Chronic fatigue (CF) is a complex phenomenon without clear etiology that may require long-term treatment, but to date, no specific therapy has been identified for it. Some botanicals might be helpful in the management of CF. Among these botanicals, quercetin demonstrates its capacity to modulate multiple biological pathways and acknowledged major properties in CF: antioxidant, anti-inflammatory, immunomodulating, improving exercise endurance, enhancing mitochondrial biogenesis, repairing mitochondrial dysfunction. Purpose: Given this background, the aim of this study was to evaluate if a 2-month period of daily Quercetin Phytosome™ 500 mg supplementation is of benefit for the relief of CF. Methods: The primary end point has been the evaluation of fatigue, by Fatigue Impact Scale (FIS-40). The secondary end points have been the assessment of sleep, by Pittsburgh Sleep Quality Index (PSQI), evaluation of muscle performance, by short physical performance battery and by wearable armband-shaped sensor in order to evaluate the number of steps, body composition, by DXA and quality of life by Short-Form 12-Item Health Survey (SF-12). Results: Seventy-eight subjects (42 F; 36 M) (mean age 56 ± 9) reporting CF symptoms, completed the study (placebo/supplement 38/40). The FIS-40 mean difference changes between groups (supplement minus placebo) was -10.583 points (CI95% -11.985; -9.182) (p < 0.001). Also, statistically significant changes between groups have been recorded in Pittsburgh Sleep Quality Index -2.040 points (CI95%: -2.770; -1.309), p < 0.01), number of steps 1443 .152 (CI95%: 1199.556;.556; 1686.749), and SPPB (score) 0.248 (CI95%: 0.105; 0.391) (p < 0.001). Conclusion: The quercetin supplementation counterbalances CF symptoms.
The authors thank the whole partnership on the Project MIND FoodS Hub: Milano Innovation District Food System Hub: Innovative concept for the eco-intensification of agricultural production and for the promotion of dietary patterns for human health and longevity through the creation in MIND of a digital Food System Hub Declaration of Competing Interest AR and GP are employed by Indena SpA. The remaining authors declare no conflict of interest.
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