Evaluation of the effect of Loigolactobacillus coryniformis K8 CECT 5711 consumption in health care workers exposed to COVID-19

{ 'indexed': {'date-parts': [[2022, 8, 3]], 'date-time': '2022-08-03T04:44:12Z', 'timestamp': 1659501852923}, 'reference-count': 28, 'publisher': 'Frontiers Media SA', 'license': [ { 'start': { 'date-parts': [[2022, 8, 3]], 'date-time': '2022-08-03T00:00:00Z', 'timestamp': 1659484800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [{'DOI': '10.13039/501100011011', 'name': 'Junta de Andalucía', 'doi-asserted-by': 'publisher'}], 'content-domain': {'domain': ['frontiersin.org'], 'crossmark-restriction': True}, 'abstract': '<jats:p>Following the spread of the SARS-CoV-2 coronavirus, an unprecedented burden has been ' 'placed on health care systems, with health care workers (HCWs) being most at risk of COVID-19 ' 'infection. The effect of the probiotic <jats:italic>Loigolactobacillus ' 'coryniformis</jats:italic> K8 CECT 5711 on frontline HCWs exposed to the virus was studied in ' 'a randomized, double-blind, placebo controlled trial. Parameters related to the incidence and ' 'severity of COVID-19 as well as the immune response and the side effects of the COVID-19 ' 'vaccine were evaluated. For 2 months, a group of 250 front-line HCWs over the age of 20 was ' 'randomly allocated to receive either <jats:italic>L. coryniformis</jats:italic> K8 or a ' 'placebo daily. SARS-CoV-2 infection incidence was verified via PCR or antigen test. In those ' 'volunteers who were vaccinated during the intervention, serum levels of specific IgG were ' 'analyzed at the end of the study. The incidence of COVID-19 infection was very low [IR (SD) = ' '0.016 (0.011)], and no significant difference was found between the groups [IRR (95% CI): ' '1.008 (0.140–7.268), <jats:italic>p</jats:italic> = 0.994]. For immune response analysis, the ' 'total sample was divided according to the days between the first dose and the antibody ' 'analysis (cutoff points were set at ≤ 56, 57–80 and ≥ 81 days). The specific IgG level ' 'decreased over time (<jats:italic>p</jats:italic> &amp;gt; 0.001). However, in the subgroup ' 'of subjects for whom more than 81 days had passed since they received the first dose, the ' 'specific IgG levels were significantly higher in the those that took the <jats:italic>L. ' 'coryniformis</jats:italic> K8 [7.12 (0.21)] than in the control group [6.48 (0.19)] ' '(<jats:italic>P</jats:italic> = 0.040). Interestingly, the subjects who started probiotic ' 'consumption before the first dose reported significantly fewer side effects (of any kind) at ' 'the 1st dose of the vaccine (OR: 0.524, <jats:italic>p</jats:italic> = 0.043), specifically ' 'less arm pain (OR: 0.467, <jats:italic>p</jats:italic> = 0.017). In conclusion, the ' 'administration of <jats:italic>L. coryniformis</jats:italic> K8 CECT 5711 to HCWs helps to ' 'extend the immune protection generated by the COVID-19 vaccine over time.</jats:p>', 'DOI': '10.3389/fnut.2022.962566', 'type': 'journal-article', 'created': {'date-parts': [[2022, 8, 3]], 'date-time': '2022-08-03T04:25:12Z', 'timestamp': 1659500712000}, 'update-policy': 'http://dx.doi.org/10.3389/crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Evaluation of the effect of Loigolactobacillus coryniformis K8 CECT 5711 consumption in health ' 'care workers exposed to COVID-19', 'prefix': '10.3389', 'volume': '9', 'author': [ {'given': 'Raquel', 'family': 'Rodriguez-Blanque', 'sequence': 'first', 'affiliation': []}, { 'given': 'Juan Carlos', 'family': 'Sánchez-García', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ángel', 'family': 'Cobos-Vargas', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ana', 'family': 'Aguilar Quesada', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jose A.', 'family': 'Maldonado-Lobón', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mónica', 'family': 'Olivares', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ruth', 'family': 'Blanco-Rojo', 'sequence': 'additional', 'affiliation': []}], 'member': '1965', 'published-online': {'date-parts': [[2022, 8, 3]]}, 'reference': [ {'key': 'B1', 'year': '2020', 'journal-title': 'Coronavirus (COVID-19) Dashboard.'}, { 'key': 'B2', 'doi-asserted-by': 'publisher', 'first-page': '559', 'DOI': '10.1016/j.bbi.2020.04.049', 'article-title': 'A multinational, multicentre study on the psychological outcomes and ' 'associated physical symptoms amongst healthcare workers during COVID-19 ' 'outbreak.', 'volume': '88', 'author': 'Chew', 'year': '2020', 'journal-title': 'Brain Behav Immun.'}, { 'key': 'B3', 'doi-asserted-by': 'publisher', 'first-page': '161', 'DOI': '10.1093/aje/kwaa191', 'article-title': 'COVID-19 in healthcare workers: a living systematic review and ' 'meta-analysis of prevalence risk factors clinical characteristics and ' 'outcomes.', 'volume': '190', 'author': 'Gómez-Ochoa', 'year': '2020', 'journal-title': 'Am J Epidemiol.'}, { 'key': 'B4', 'doi-asserted-by': 'publisher', 'first-page': '1727', 'DOI': '10.1016/j.ajem.2020.05.113', 'article-title': 'COVID-19 in health care workers – a systematic review and ' 'meta-analysis.', 'volume': '38', 'author': 'Sahu', 'year': '2020', 'journal-title': 'Am J Emerg Med.'}, { 'key': 'B5', 'doi-asserted-by': 'publisher', 'first-page': '582', 'DOI': '10.1016/j.arcmed.2021.03.002', 'article-title': 'Probiotics in prevention and treatment of covid-19: current perspective ' 'and future prospects.', 'volume': '52', 'author': 'Kurian', 'year': '2021', 'journal-title': 'Arch Med Res.'}, { 'key': 'B6', 'doi-asserted-by': 'publisher', 'first-page': '1', 'DOI': '10.1016/j.nutres.2020.12.014', 'article-title': 'Probiotics: a potential immunomodulator in COVID-19 infection ' 'management.', 'volume': '87', 'author': 'Singh', 'year': '2021', 'journal-title': 'Nutr Res.'}, { 'key': 'B7', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.micpath.2020.104452', 'article-title': 'The immunomodulatory effects of probiotics on respiratory viral ' 'infections: a hint for COVID-19 treatment?', 'volume': '148', 'author': 'Mahooti', 'year': '2020', 'journal-title': 'Microb Pathog.'}, { 'key': 'B8', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/19490976.2021.2018899', 'article-title': 'Probiotic improves symptomatic and viral clearance in Covid19 ' 'outpatients: a randomized, quadruple-blinded, placebo-controlled trial.', 'volume': '14', 'author': 'Gutiérrez-Castrellón', 'year': '2022', 'journal-title': 'Gut Microbes.'}, { 'key': 'B9', 'first-page': '47', 'article-title': 'The consumption of two new probiotic strains Lactobacillus Gasseri CECT ' '5714 and Lactobacillus Coryniformis CECT 5711 boosts the immune system ' 'of healthy humans.', 'volume': '9', 'author': 'Olivares', 'year': '2006', 'journal-title': 'Int Microbiol.'}, { 'key': 'B10', 'first-page': '496', 'article-title': 'Efectos beneficiosos en niños sanos del consumo de un producto lácteo ' 'que contiene dos cepas probióticas. 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