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0 0.5 1 1.5 2+ Recovery 89% Improvement Relative Risk Rathi et al. CTRI/2021/05/033576 Probiotics RCT LONG COVID Does probiotics reduce the risk of Long COVID (PASC)? Double-blind RCT 200 patients in India Improved recovery with probiotics (p<0.000001) Rathi et al., Medicines, doi:10.3390/medicines8090047 Favors probiotics Favors control
A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue
Rathi et al., A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of.., Medicines, doi:10.3390/medicines8090047, CTRI/2021/05/033576
Aug 2021   Source   PDF  
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RCT 200 long-COVID patients in India, 100 treated with ImmunoSEB and ProbioSEB CSC3, showing improved recovery of post-COVID-19 fatigue with treatment. CTRI/2021/05/033576.
The immune effects of probiotics are strain-specific.
risk of no recovery, 89.4% lower, RR 0.11, p < 0.001, treatment 9 of 100 (9.0%), control 85 of 100 (85.0%), NNT 1.3, day 14, fatigue.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rathi et al., 30 Aug 2021, Double Blind Randomized Controlled Trial, placebo-controlled, India, peer-reviewed, 3 authors, trial CTRI/2021/05/033576.
Contact: (corresponding author),,
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Abstract: medicines Article A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue Abhijit Rathi 1, *, Swati B. Jadhav 1 and Neha Shah 2 1 2 *   Citation: Rathi, A.; Jadhav, S.B.; Food Application and Development Laboratory, Advanced Enzymes Technologies Ltd., Louiswadi, Thane 400604, India; Pulmonary Fibrosis Now, Chino, CA 91710, USA; Correspondence: Abstract: Muscle fatigue and cognitive disturbances persist in patients after recovery from acute COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) in patients suffering from COVID-19 induced fatigue. A randomized, multicentric, double blind, placebo-controlled trial was conducted in 200 patients with a complaint of post-COVID fatigue. The test arm (n = 100) received the oral supplements for 14 days and the control arm (n = 100) received a placebo. Treatment efficacy was compared using the Chalder Fatigue scale (CFQ-11), at various time points from days 1 to 14. The supplemental treatment resulted in resolution of fatigue in a greater percentage of subjects in the test vs. the control arm (91% vs. 15%) on day 14. Subjects in the test arm showed a significantly greater reduction in total as well as physical and mental fatigue scores at all time points vs. the control arm. The supplements were well tolerated with no adverse events reported. This study demonstrates that a 14 days supplementation of ImmunoSEB + ProbioSEB CSC3 resolves post-COVID-19 fatigue and can improve patients’ functional status and quality of life. Shah, N. A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Keywords: SARS-CoV-2 infection; COVID-19-induced fatigue; chalder fatigue scale; physical fatigue; mental fatigue; ImmunoSEB + ProbioSEB CSC3 Resolution of Post-COVID Fatigue. Medicines 2021, 8, 47. 10.3390/medicines8090047
Late treatment
is less effective
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