A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue
RCT 200 long-COVID patients in India, 100 treated with ImmunoSEB and ProbioSEB CSC3, showing improved recovery of post-COVID-19 fatigue with treatment. CTRI/2021/05/033576.
The immune effects of probiotics are strain-specific.
risk of no recovery, 89.4% lower, RR 0.11, p < 0.001, treatment 9 of 100 (9.0%), control 85 of 100 (85.0%), NNT 1.3, day 14, fatigue.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rathi et al., 30 Aug 2021, Double Blind Randomized Controlled Trial, placebo-controlled, India, peer-reviewed, 3 authors, trial CTRI/2021/05/033576
firstname.lastname@example.org (corresponding author), email@example.com, firstname.lastname@example.org.
A Randomized Controlled Trial of the Efficacy of Systemic
Enzymes and Probiotics in the Resolution of Post-COVID Fatigue
Abhijit Rathi 1, *, Swati B. Jadhav 1 and Neha Shah 2
Citation: Rathi, A.; Jadhav, S.B.;
Food Application and Development Laboratory, Advanced Enzymes Technologies Ltd., Louiswadi,
Thane 400604, India; email@example.com
Pulmonary Fibrosis Now, Chino, CA 91710, USA; firstname.lastname@example.org
Abstract: Muscle fatigue and cognitive disturbances persist in patients after recovery from acute
COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To
evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex)
and ProbioSEB CSC3 (probiotic complex) in patients suffering from COVID-19 induced fatigue.
A randomized, multicentric, double blind, placebo-controlled trial was conducted in 200 patients
with a complaint of post-COVID fatigue. The test arm (n = 100) received the oral supplements for
14 days and the control arm (n = 100) received a placebo. Treatment efficacy was compared using
the Chalder Fatigue scale (CFQ-11), at various time points from days 1 to 14. The supplemental
treatment resulted in resolution of fatigue in a greater percentage of subjects in the test vs. the control
arm (91% vs. 15%) on day 14. Subjects in the test arm showed a significantly greater reduction
in total as well as physical and mental fatigue scores at all time points vs. the control arm. The
supplements were well tolerated with no adverse events reported. This study demonstrates that a
14 days supplementation of ImmunoSEB + ProbioSEB CSC3 resolves post-COVID-19 fatigue and can
improve patients’ functional status and quality of life.
Shah, N. A Randomized Controlled
Trial of the Efficacy of Systemic
Enzymes and Probiotics in the
Keywords: SARS-CoV-2 infection; COVID-19-induced fatigue; chalder fatigue scale; physical fatigue;
mental fatigue; ImmunoSEB + ProbioSEB CSC3
Resolution of Post-COVID Fatigue.
Medicines 2021, 8, 47. https://doi.org/
is less effective
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