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Sodium Bicarbonate Nebulized Therapy in Patients with Confirmed COVID-19

Rashedi et al., Advanced Pharmaceutical Bulletin, doi:10.34172/apb.2021.047
Oct 2020  
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28th treatment shown to reduce risk in November 2021, now with p = 0.0000000046 from 14 studies.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Proposal for nebulized sodium bicarbonate therapy for prevention of SARS-CoV-2 infection by raising endosomal pH and inhibiting viral entry into cells. Author proposes that inhalation of nebulized sodium bicarbonate solution (<5%) several times per day by COVID-19 patients may stop viral fusion and uncoating stages. Author notes that prospective controlled trials are needed.
Reviews covering alkalinization for COVID-19 include1-3.
Rashedi et al., 14 Oct 2020, peer-reviewed, 3 authors.
This PaperAlkalinizationAll
Sodium Bicarbonate Nebulized Therapy in Patients with Confirmed COVID-19
Behroz Jalil Rashedi, Behroz Mahdavi Poor, Mohammad Asgharzadeh
Advanced Pharmaceutical Bulletin, doi:10.34172/apb.2021.047
replication phase will also remain barren and eventually the respiratory infection will be controlled. Prospective controlled trials are needed to evaluate this method efficacy.
Ethical Issues Not applicable. Conflict of Interest The authors declare that there is no conflict of interests.
References
Belouzard, Millet, Licitra, Whittaker, None
Hofmann, Pöhlmann, Cellular entry of the SARS coronavirus, Trends Microbiol, doi:10.1016/j.tim.2004.08.008
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