Sodium Bicarbonate Nebulized Therapy in Patients with Confirmed COVID-19

Rashedi et al., Advanced Pharmaceutical Bulletin, doi:10.34172/apb.2021.047, Oct 2020
31st treatment shown to reduce risk in November 2021, now with p = 0.0000000039 from 14 studies.
No treatment is 100% effective. Protocols combine treatments.
6,300+ studies for 210+ treatments. c19early.org
Proposal for nebulized sodium bicarbonate therapy for prevention of SARS-CoV-2 infection by raising endosomal pH and inhibiting viral entry into cells. Author proposes that inhalation of nebulized sodium bicarbonate solution (<5%) several times per day by COVID-19 patients may stop viral fusion and uncoating stages. Author notes that prospective controlled trials are needed.
Reviews covering alkalinization for COVID-19 include1-3.
Rashedi et al., 14 Oct 2020, peer-reviewed, 3 authors.
Sodium Bicarbonate Nebulized Therapy in Patients with Confirmed COVID-19
Behroz Jalil Rashedi, Behroz Mahdavi Poor, Mohammad Asgharzadeh
Advanced Pharmaceutical Bulletin, doi:10.34172/apb.2021.047
replication phase will also remain barren and eventually the respiratory infection will be controlled. Prospective controlled trials are needed to evaluate this method efficacy.
Ethical Issues Not applicable. Conflict of Interest The authors declare that there is no conflict of interests.
References
Belouzard, Millet, Licitra, Whittaker, None
Hofmann, Pöhlmann, Cellular entry of the SARS coronavirus, Trends Microbiol, doi:10.1016/j.tim.2004.08.008
DOI record: { "DOI": "10.34172/apb.2021.047", "ISSN": [ "2228-5881", "2251-7308" ], "URL": "http://dx.doi.org/10.34172/apb.2021.047", "assertion": [ { "label": "Journal Owner", "name": "journal_owner", "value": "Tabriz University of Medical Sciences" }, { "label": "Journal Publisher", "name": "journal_publisher", "value": "Tabriz University of Medical Sciences" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 1, "value": "2020-05-09" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2020-10-14" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 3, "value": "2020-10-14" } ], "author": [ { "ORCID": "http://orcid.org/0000-0002-9627-1491", "affiliation": [ { "name": "Department of Laboratory Sciences, School of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran." } ], "authenticated-orcid": true, "family": "Rashedi", "given": "Jalil", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0002-8856-3750", "affiliation": [ { "name": "Department of Laboratory Sciences, School of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran." } ], "authenticated-orcid": true, "family": "Mahdavi Poor", "given": "Behroz", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-3386-4342", "affiliation": [ { "name": "Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran." } ], "authenticated-orcid": true, "family": "Asgharzadeh", "given": "Mohammad", "sequence": "additional" } ], "container-title": "Advanced Pharmaceutical Bulletin", "container-title-short": "Adv Pharm Bull", "content-domain": { "crossmark-restriction": false, "domain": [ "apb.tbzmed.ac.ir" ] }, "created": { "date-parts": [ [ 2021, 7, 5 ] ], "date-time": "2021-07-05T15:12:03Z", "timestamp": 1625497923000 }, "deposited": { "date-parts": [ [ 2021, 7, 5 ] ], "date-time": "2021-07-05T15:12:03Z", "timestamp": 1625497923000 }, "indexed": { "date-parts": [ [ 2024, 2, 7 ] ], "date-time": "2024-02-07T21:01:14Z", "timestamp": 1707339674306 }, "is-referenced-by-count": 2, "issue": "3", "issued": { "date-parts": [ [ 2020, 10, 14 ] ] }, "journal-issue": { "issue": "3", "published-online": { "date-parts": [ [ 2021, 5 ] ] } }, "language": "en", "link": [ { "URL": "https://apb.tbzmed.ac.ir/PDF/apb-11-397.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://apb.tbzmed.ac.ir/PDF/apb-11-397.pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "20123", "original-title": [], "page": "397-398", "prefix": "10.34172", "published": { "date-parts": [ [ 2020, 10, 14 ] ] }, "published-online": { "date-parts": [ [ 2020, 10, 14 ] ] }, "published-print": { "date-parts": [ [ 2020, 10, 14 ] ] }, "publisher": "Maad Rayan Publishing Company", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "https://apb.tbzmed.ac.ir/Article/apb-28931" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Sodium Bicarbonate Nebulized Therapy in Patients with Confirmed COVID-19", "type": "journal-article", "update-policy": "http://dx.doi.org/10.34172/crossmark_policy", "volume": "11" }
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
  or use drag and drop   
Submit