Vitamin D, Zinc and Iron in Adult Patients with Covid-19 and Their Action in the Immune Response as Biomarkers
Eliza Miranda Ramos, Emerson Luiz Lima Araújo, Francisco José Mendes Dos Reis, Igor Domingos De Souza, Gilberto Gonçalves Facco, Iara Barbosa Ramos, Pamella Aline Miranda Teodoro, Antônio Carlos De Abreu, Alessandro Carvalho Da Fonseca, Ernani Mendes Da Fonseca Junior, Valter Aragão Do Nascimento
Global Journal of Health Science, doi:10.5539/gjhs.v14n1p1
COVID-19 in 2020 brought challenges to the Brazilian public health system with an emerging virus with respiratory contagion called SARS-CoV-2. There are few studies in Brazil and in some countries, on the increased incidence of certain viral respiratory infections, including H1N1 and coronavirus and their association with low levels of vitamin D, zinc and iron. The aim of this study was to demonstrate that the deficit of vitamin D, zinc and iron has an impact on the infectious process of patients with COVID-19 and to establish new forms of prevention for the worsening of COVID-19 in the human body. Data were collected from medical records and test results from patients being followed up during the treatment period for COVID-19. Patients with low blood levels of vitamin D, zinc and iron during the treatment period of COVID-19 had a higher percentage of worsening and complications requiring hospitalization in intensive care beds. The ingestion of vitamin D, zinc and iron in the treatment period of patients with COVID-19 in addition to being an immunological protector against SARS-CoV-2 and alleviating the process of worsening the disease can also act as a biomarker in cases of this disease.
Author Contributions Conceituação: E.M.R. and V.A.N.; concepção e síntese de compostos, E.M.R. and V.A.
Sample Availability Samples of the compounds are available from the authors.
Competing Interests Statement The authors declare that there are no competing or potential conflicts of interest.
References
Ampawong, Chaisri, Viriyavejakul, Prapansilp, Grau et al., A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury, Malaria journal,
doi:10.1186/s12936-015-0922-xAndrade, Reis-Filho, Barros, Souza-Neto, Nogueira et al., Towards a precise test for malaria diagnosis in the Brazilian Amazon: comparison among field microscopy, a rapid diagnostic test, nested PCR, and a computational expert system based on artificial neural networks, Malaria journal,
doi:10.1186/1475-2875Anstey, Jacups, Cain, Pearson, Ziesing et al., Pulmonary manifestations of uncomplicated falciparum and vivax malaria: cough, small airways obstruction, impaired gas transfer, and increased pulmonary phagocytic activity, The Journal of infectious diseases,
doi:10.1086/339885Brenner, Holleczek, Schöttker, Vitamin D insufficiency and deficiency and mortality from respiratory diseases in a cohort of older adults: potential for limiting the death toll during and beyond the COVID-19 pandemic?, Nutrients,
doi:10.3390/nu12082488Castro, Silva-Nunes, Conde, Muniz, Cardoso, Anemia and iron deficiency among schoolchildren in the Western Brazilian Amazon: prevalence and associated factors, Cadernos de saude publica,
doi:10.1590/S0102-311X2011000100014Cen, Chen, Shen, Zhang, Lei et al., Risk factors for disease progression in patients with mild to moderate coronavirus disease 2019-a multi-centre observational study, Clinical Microbiology and Infection,
doi:10.1016/j.cmi.2020.05.041Chan, Yuan, Kok, To, Chu et al., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster, The lancet
Cooper, Crofts, Dinicolantonio, Malhotra, Elliott et al., Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management, Open Heart,
doi:10.1136/openhrt-2020-001356D'avolio, Avataneo, Manca, Cusato, De Nicolò et al., 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2, Nutrients,
doi:10.3390/nu12051359Fawzi, Villamor, Msamanga, Antelman, Aboud et al., Trial of zinc supplements in relation to pregnancy outcomes, hematologic indicators, and T cell counts among HIV-1-infected women in Tanzania, The American journal of clinical nutrition,
doi:10.1093/ajcn/81.1.161Giacomelli, Ridolfo, Milazzo, Oreni, Bernacchia et al., 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study, Pharmacological research,
doi:10.1016/j.phrs.2020.104931Gladwin, Kato, Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens!, Haematologica,
doi:10.3324/haematol.12318Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients,
doi:10.3390/nu12040988Gruber-Bzura, Vitamin D and influenza-prevention or therapy?, International journal of molecular sciences,
doi:10.3390/ijms19082419Huang, Tu, Wang, Chen, Zhou et al., Clinical characteristics of laboratory confirmed positive cases of SARS-CoV-2 infection in Wuhan, China: A retrospective single center analysis, Travel medicine and infectious disease,
doi:10.1016/j.tmaid.2020.101606Jin, Lee, Kim, The prevalence of vitamin D deficiency in iron-deficient and normal children under the age of 24 months, Blood research,
doi:10.5045/br.2013.48.1.40Malek Mahdavi, A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19, Reviews in Medical Virology,
doi:10.1002/rmv.2119Mohammad, Mishra, Ashraf, Emerging role of vitamin D and its associated molecules in pathways related to pathogenesis of thrombosis, Biomolecules,
doi:10.3390/biom9110649Opas, Folha informativa -COVID-19 (doença causada pelo novo coronavírus
Prasad, Bao, Beck, Sarkar, Zinc-suppressed inflammatory cytokines by induction of A20-mediated inhibition of nuclear factor-κB, Nutrition,
doi:10.1016/j.nut.2010.08.010Ramos, De Abreu, De Freitas, De Lima, Reis et al., COVID-19, rate of case factors and nutritional characteristics of patients dying in Italy and Brazil: a critical analyze, Global J Health Sci,
doi:10.5539/gjhs.v12n7p133Ramos, Mendes Dos Reis, De Souza, De Freitas, De Lima et al., Does Vitamin D Supplementation have a Positive and Important Response in the Immune System on Covid-19 Pandemic? A Short Critical Analysis, International Journal,
doi:10.15640/ijmp.v8n1a5Ramos, Mendes Dos Reis, Ramos, De Souza, Bochenek, Vitamin D produce antibodies in pandemic response to gripal viruses? A critical analysis, Int J Clin Virol,
doi:10.29328/journal.ijcv.1001010Razzaque, COVID-19 pandemic: can maintaining optimal zinc balance enhance host resistance?, The Tohoku journal of experimental medicine,
doi:10.1620/tjem.251.175Xu, Huang, Zhu, Wang, Cheng et al., Epidemiological and clinical features of asymptomatic patients with SARS-CoV-2 infection, Journal of medical virology,
doi:10.1002/jmv.25944Zhou, Yu, Du, Fan, Liu et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, The lancet,
doi:10.1016/S0140-6736
