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c19early.org COVID-19 treatment researchN-acetylcysteineN-acetylcys.. (more..)
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All Studies   All Outcomes   Recent:  
0 0.5 1 1.5 2+ Mortality 33% Improvement Relative Risk Hospitalization time 8% N-acetylcysteine  Rahimi et al.  ICU PATIENTS  RCT Is very late treatment with N-acetylcysteine beneficial for COVID-19? RCT 40 patients in Iran Lower mortality with N-acetylcysteine (not stat. sig., p=0.19) c19early.org Rahimi et al., Jundishapur J. Natural .., Oct 2022 Favors N-acetylcysteine Favors control

Efficacy of N-acetyl Cysteine in Severe COVID-19 Patients: A Randomized Controlled Phase III Clinical Trial

Rahimi et al., Jundishapur Journal of Natural Pharmaceutical Products, doi:10.5812/jjnpp-129817
Oct 2022  
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RCT 40 ICU patients in Iran, showing lower mortality with NAC treatment, without statistical significance. Single dose intravenous NAC 300 mg/kg.
Although the 33% lower mortality is not statistically significant, it is consistent with the significant 23% lower mortality [7‑37%] from meta analysis of the 18 mortality results to date.
risk of death, 33.3% lower, RR 0.67, p = 0.19, treatment 10 of 20 (50.0%), control 15 of 20 (75.0%), NNT 4.0.
hospitalization time, 7.5% lower, relative time 0.92, p = 0.63, treatment 20, control 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Rahimi et al., 8 Oct 2022, Single Blind Randomized Controlled Trial, Iran, peer-reviewed, 10 authors.
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This PaperN-acetylcys..All
Late treatment
is less effective
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