Laurent Hi, William B Grant, Yingxia Liu, Peng D Huang, Denggao Peng, Hua Huang, Zhichao Liu, Yanzhang Gao
Conclusions: Children with vitamin D insu ciency might have poorer clinical outcomes in Omicron subvariant BA. infection, especially in older pediatric patients. Further studies are needed to assess e ectiveness of supplements in reducing the same.
Ethics statement This investigation involving human participants were reviewed and approved by the Ethics Committee of The Third People's Hospital of Shenzhen (Approval Number: 2022-012). Written informed consent for participation was not provided by the participants' legal guardians/next of kin because: Written informed consent from patients participating in this study was waived in accordance with the national legislation and the institutional requirements.
Author contributions DP: methodology, investigation, formal analysis, data curation, writing the original draft, and visualization. HH and ZL: investigation, formal analysis, and data curation. YL: conceptualization, investigation, review and editing, and supervision. ZL, YG, and HH: worked on conceptualization, formal analysis, investigation, and data curation. All authors have read and approved the final manuscript version to be submitted.
Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material..
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doi:10.1016/S0140-6736(22)00327-0{ 'indexed': {'date-parts': [[2022, 7, 25]], 'date-time': '2022-07-25T09:13:44Z', 'timestamp': 1658740424582},
'reference-count': 29,
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'timestamp': 1658707200000},
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'abstract': '<jats:sec><jats:title>Objective</jats:title><jats:p>To investigate the picture between '
'vitamin D levels and clinical outcomes of SARS-CoV-2 Omicron subvariant BA.2 in '
'children.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A '
'retrospective, longitudinal cohort study was performed. All included hospitalized cases were '
'divided into the sufficient (sVD) and insufficient vitamin D (iVD) groups according to '
'whether their serum 25-hydroxyvitamin D [25(OH)D] concentration was ≥30 ng/mL. Dynamic '
'changes in clinical parameters were observed for seven time periods within 28 days after '
'admission.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Serum 25(OH)D '
'concentrations were significantly negatively correlated with age in the included cases '
'(<jats:italic>r</jats:italic> = −0.6; <jats:italic>P</jats:italic> &lt; 0.001). Compared '
'with the iVD group (<jats:italic>n</jats:italic> = 80), the sVD group '
'(<jats:italic>n</jats:italic> = 36) had higher interleukin-6 (18.4 vs. 12.9; '
'<jats:italic>P</jats:italic> = 0.003) within the first day; higher procalcitonin within the '
'first (0.15 vs. 0.1; <jats:italic>P</jats:italic> = 0.03), 2–3 (0.14 vs. 0.07; '
'<jats:italic>P</jats:italic> = 0.03), 4–5 (0.21 vs. 0.07; <jats:italic>P</jats:italic> = '
'0.02) days; more lymphocytes within the first (1.6 vs. 1.2; <jats:italic>P</jats:italic> = '
'0.02), 2–3 (3.7 vs. 2; <jats:italic>P</jats:italic> = 0.001), 4–5 (3.9 vs. 2.1; '
'<jats:italic>P</jats:italic> = 0.01) and 6–7 (4.9 vs. 2.7; <jats:italic>P</jats:italic> = '
'0.02) days; notably, higher cycle threshold for N gene (30.6 vs 19.8; '
'<jats:italic>P</jats:italic> = 0.03) or ORF1ab gene (31.4 vs 20.1; '
'<jats:italic>P</jats:italic> = 0.03) within 2 to 3 days. Pneumonia lesions were found in '
'eleven and six cases in the iVD and sVD groups, respectively, without significant difference '
'on computed tomography at admission. Six out of eleven and five out of six had a repeat '
'computed tomography after 1–2 weeks. Lesion improvement was more significant in the sVD group '
'(<jats:italic>P</jats:italic> = '
'0.04).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Children with '
'vitamin D insufficiency might have poorer clinical outcomes in Omicron subvariant BA.2 '
'infection, especially in older pediatric patients. Further studies are needed to assess '
'effectiveness of supplements in reducing the same.</jats:p></jats:sec>',
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