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0 0.5 1 1.5 2+ Moderate/severe case 70% Improvement Relative Risk Bayramoğlu et al. Vitamin D for COVID-19 Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 103 patients in Turkey Lower severe cases with higher vitamin D levels (p=0.027) Bayramoğlu et al., European J. Pediatrics, doi:10.1007/s00431-021-04030-1 Favors vitamin D Favors control
The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital
Bayramoğlu et al., European Journal of Pediatrics, doi:10.1007/s00431-021-04030-1
Bayramoğlu et al., The association between vitamin D levels and the clinical severity and inflammation markers in pediatric.., European Journal of Pediatrics, doi:10.1007/s00431-021-04030-1
Mar 2021   Source   PDF  
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Retrospective 103 pediatric hospitalized COVID-19 patients, showing an association between vitamin D deficiency and clinical severity.
risk of moderate/severe case, 69.5% lower, RR 0.30, p = 0.03, high D levels 10 of 60 (16.7%), low D levels 24 of 43 (55.8%), NNT 2.6, adjusted per study, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, >12 ng/mL, multivariate logistic regression.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bayramoğlu et al., 31 Mar 2021, retrospective, Turkey, peer-reviewed, 7 authors.
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Abstract: European Journal of Pediatrics (2021) 180:2699–2705 ORIGINAL ARTICLE The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital Elvan Bayramoğlu 1 & Gülşen Akkoç 2 & Ayşe Ağbaş 3 Hatice Nilgün Selçuk Duru 4 & Murat Elevli 4 & Özlem Akgün 4 & Kamer Yurdakul 5 & Received: 22 November 2020 / Revised: 8 March 2021 / Accepted: 12 March 2021 / Published online: 31 March 2021 # Springer-Verlag GmbH Germany, part of Springer Nature 2021 Abstract Vitamin D has an immunomodulating property that regulates the inflammatory response. In this study, the aim was to evaluate the relationship between vitamin D levels and clinical severity and inflammation markers in children and adolescents with COVID-19. The clinical and laboratory records of 103 pediatric cases with COVID-19, whose vitamin D levels had been measured, were retrospectively reviewed. The cases were divided into groups according to their clinical severity (asymptomatic, mild, and moderate-to-severe) and vitamin D levels. The moderate-to-severe clinical group had significantly higher inflammation markers (CRP, procalcitonin, fibrinogen, Ddimer) and a lower lymphocyte count compared to both the mild and asymptomatic groups. The 25 OH vitamin D levels were also significantly lower (p < 0.001), and the ratio of vitamin D deficiency was 70.6% in the moderate-to-severe group. The vitamin D–deficient group had a significantly higher age and fibrinogen levels while also having a lower lymphocyte count compared to the insufficient and normal groups. The 25 OH vitamin D level was correlated positively with the lymphocyte count (r = 0.375, p = <0.001), and negatively with age (r = −0.496, p = <0.001), CRP (r = −0.309, p = 0.002) and fibrinogen levels (r = −0.381, p = <0.001). In a logistic regression analysis, vitamin D deficiency, D-dimer, and fibrinogen levels on admission were independent predictors of severe clinical course. Conclusion: This study revealed an association between vitamin D deficiency and clinical severity, in addition to inflammation markers in pediatric COVID-19 cases. Prophylactic vitamin D supplementation may be considered, especially in the adolescent age group. What is Known: • • The pathology of COVID-19 involves a complex interaction between the SARS-CoV-2 and the immune system. Hyperinflammation/cytokine storm is held responsible for the severity of the disease. • Vitamin D has multiple roles in the immune system that can modulate the body reaction to an infection. What is New: • • Clinically more severe group had significantly lower vit D levels and significantly higher inflammation markers. • Lower 25 OH vit D levels were associated with higher inflammation markers, suggesting an important role of vitamin D in the clinical course of COVID-19 in children and adolescents probably by regulating the systemic inflammatory response. Keywords COVID-19 . Vitamin D . Inflammation . Children . Pediatric Communicated by Peter de Winter * Elvan Bayramoğlu Gülşen Akkoç Ayşe Ağbaş Özlem Akgün Kamer Yurdakul Hatice Nilgün Selçuk Duru Murat Elevli Extended author information available on the last page of the article 2700 Eur J Pediatr (2021)..
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