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Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific

Oh et al., Frontiers in Immunology, doi:10.3389/fimmu.2021.594356
Jun 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 98 treatments. c19early.org
Analysis of 2,095 patients in South Korea, showing exercise and vitamin D associated with improved natural killer cell activity.
Graydon showed that a lower frequency of natural killer cells was associated with symptomatic COVID-19 infection.
Study covers exercise and vitamin D.
Oh et al., 23 Jun 2021, retrospective, South Korea, peer-reviewed, 8 authors. Contact: sangwoon.choi@gmail.com.
This PaperVitamin DAll
Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific
Sooyeon Oh, Sukyung Chun, Sena Hwang, Jongseok Kim, Yuri Cho, Jooho Lee, Kyubum Kwack, Sang-Woon Choi
Frontiers in Immunology, doi:10.3389/fimmu.2021.594356
Background: The coronavirus-19 disease (COVID-19) pandemic reminds us of the importance of immune function, even in immunologically normal individuals. Multiple lifestyle factors are known to influence the immune function. Objective: The aim was to investigate the association between NK cell activity (NKA) and multiple factors including vitamin D, physical exercise, age, and gender. Methods: This was a cross-sectional association study using health check-up and NKA data of 2,095 subjects collected from 2016 to 2018 in a health check-up center in the Republic of Korea. NKA was measured using the interferon-g (IFN-g) stimulation method. The association of NKA with 25-(OH)-vitamin D (25(OH)D) and other factors was investigated by multiple logistic regression analysis. Results: The average age of subjects was 48.8 ± 11.6 years (52.9% of subjects were female). Among 2,095 subjects, 1,427 had normal NKA (NKA ≥ 500 pg IFN-g/mL), while 506 had low NKA (100 ≤ NKA < 500 pg/mL), and 162 subjects had very low NKA (NKA < 100 pg/mL). Compared to men with low 25(OH)D serum level (< 20 ng/mL), vitamin D replete men (30-39.9 ng/mL) had significantly lower risk of very low NKA (OR: 0.358; 95% CI: 0.138, 0.929; P = 0.035). In women, both low exercise (OR: 0.529; 95% CI: 0.299, 0.939; P = 0.030) and medium to high exercise (OR: 0.522; 95% CI: 0.277, 0.981; P = 0.043) decreased the risk compared to lack of physical exercise. Interestingly, in men and women older than 60 years, physical exercise significantly decreased the risk. Older-age was associated with increased risk of very low NKA in men, but not in women. Conclusion: Physical exercise and vitamin D were associated with NKA in a genderand age-dependent manner. Age was a major risk factor of very low NKA in men but not in women.
ETHICS STATEMENT The studies involving human participants were reviewed and approved by CHA Bundang Medical Center. Written informed consent for participation was not required for this study in acc ordance with the national l egis lation and the institutional requirements. AUTHOR CONTRIBUTIONS SO, SC, and S-WC contributed to the study design, data collection, study analysis, manuscript writing, critical review of the manuscript, and final approval of the manuscript submission. SH, JK, YC, JL, and KK assisted in analyzing and interpreting the data, critical review of the manuscript. All authors contributed to the article and approved the submitted version. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Multiple lifestyle factors are known to influence the immune ' 'function.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>The aim was ' 'to investigate the association between NK cell activity (NKA) and multiple factors including ' 'vitamin D, physical exercise, age, and ' 'gender.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This was a ' 'cross-sectional association study using health check-up and NKA data of 2,095 subjects ' 'collected from 2016 to 2018 in a health check-up center in the Republic of Korea. NKA was ' 'measured using the interferon-γ (IFN-γ) stimulation method. The association of NKA with ' '25-(OH)-vitamin D (25(OH)D) and other factors was investigated by multiple logistic ' 'regression analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The ' 'average age of subjects was 48.8 ± 11.6 years (52.9% of subjects were female). Among 2,095 ' 'subjects, 1,427 had normal NKA (NKA ≥ 500 pg IFN-γ/mL), while 506 had low NKA (100 ≤ NKA ' '&amp;lt; 500 pg/mL), and 162 subjects had very low NKA (NKA &amp;lt; 100 pg/mL). Compared to ' 'men with low 25(OH)D serum level (&amp;lt; 20 ng/mL), vitamin D replete men (30–39.9 ng/mL) ' 'had significantly lower risk of very low NKA (OR: 0.358; 95% CI: 0.138, 0.929; ' '<jats:italic>P</jats:italic> = 0.035). In women, both low exercise (OR: 0.529; 95% CI: 0.299, ' '0.939; <jats:italic>P</jats:italic> = 0.030) and medium to high exercise (OR: 0.522; 95% CI: ' '0.277, 0.981; <jats:italic>P</jats:italic> = 0.043) decreased the risk compared to lack of ' 'physical exercise. Interestingly, in men and women older than 60 years, physical exercise ' 'significantly decreased the risk. Older-age was associated with increased risk of very low ' 'NKA in men, but not in ' 'women.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Physical ' 'exercise and vitamin D were associated with NKA in a gender- and age-dependent manner. 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