Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study

DOI record: { "DOI": "10.1186/s43168-022-00154-6", "ISSN": [ "1687-8426", "2314-8551" ], "URL": "http://dx.doi.org/10.1186/s43168-022-00154-6", "abstract": "<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Background</jats:title>\n <jats:p>This pilot study included 68 cases with post-COVID-19 persistent cough (&gt; 8 weeks), randomly allocated into two groups; intervention group (32 patients) received standard cough therapy, and montelukast 10 mg/day for 14 days and control group (36 patients) received only cough sedatives.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n <jats:p>We found a significant improvement in the number of cough paroxysms/day, cough severity visual analog scale, cough severity index and cough quality of life, shorter duration improvement, and minimal side effects in the interventional group.</jats:p>\n </jats:sec><jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>We suggest that montelukast may be effective to reduce the duration and severity of the persistent post-COVID-19 cough and further improve quality of life.</jats:p>\n </jats:sec>", "alternative-id": [ "154" ], "article-number": "52", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "27 June 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "28 August 2022" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "15 September 2022" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Ethics approval and consent to participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The Research Ethics Committee at the Faculty of Medicine, Aswan University, has approved the study (IRB number: aswu/469/7/2020), and all patients provided written informed consent before participation." }, { "group": { "label": "Consent for publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "The manuscript has been read and approved by all the authors." }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "The authors declare that they have no competing interests." } ], "author": [ { "ORCID": "http://orcid.org/0000-0002-7111-2195", "affiliation": [], "authenticated-orcid": false, "family": "Mohamed Hussein", "given": "Aliae A. R.", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0001-6068-5724", "affiliation": [], "authenticated-orcid": false, "family": "Ibrahim", "given": "Mohamed Eltaher A. A.", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0001-6002-6796", "affiliation": [], "authenticated-orcid": false, "family": "Makhlouf", "given": "Hoda A.", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-2949-4369", "affiliation": [], "authenticated-orcid": false, "family": "Makhlouf", "given": "Nahed A.", "sequence": "additional" }, { "affiliation": [], "family": "Abd-Elaal", "given": "Howaida K.", "sequence": "additional" }, { "affiliation": [], "family": "Kholief", "given": "Karima M. S.", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-0844-4215", "affiliation": [], "authenticated-orcid": false, "family": "Sayed", "given": "Islam G.", "sequence": "additional" } ], "container-title": "The Egyptian Journal of Bronchology", "container-title-short": "Egypt J Bronchol", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2022, 9, 15 ] ], "date-time": "2022-09-15T12:07:37Z", "timestamp": 1663243657000 }, "deposited": { "date-parts": [ [ 2022, 9, 15 ] ], "date-time": "2022-09-15T12:11:37Z", "timestamp": 1663243897000 }, "indexed": { "date-parts": [ [ 2024, 5, 4 ] ], "date-time": "2024-05-04T01:37:09Z", "timestamp": 1714786629793 }, "is-referenced-by-count": 6, "issue": "1", "issued": { "date-parts": [ [ 2022, 9, 15 ] ] }, "journal-issue": { "issue": "1", "published-print": { "date-parts": [ [ 2022, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 9, 15 ] ], "date-time": "2022-09-15T00:00:00Z", "timestamp": 1663200000000 } }, { "URL": "https://creativecommons.org/licenses/by/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 9, 15 ] ], "date-time": "2022-09-15T00:00:00Z", "timestamp": 1663200000000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1186/s43168-022-00154-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1186/s43168-022-00154-6/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1186/s43168-022-00154-6.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1186", "published": { "date-parts": [ [ 2022, 9, 15 ] ] }, "published-online": { "date-parts": [ [ 2022, 9, 15 ] ] }, "published-print": { "date-parts": [ [ 2022, 12 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1001/jama.2020.12603", "author": "A Carfì", "doi-asserted-by": "publisher", "first-page": "603", "issue": "6", "journal-title": "JAMA.", "key": "154_CR1", "unstructured": "Carfì A, Bernabei R, Landi F (2020) For the gemelli against COVID-19 post-acute care study group. 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