Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a non-randomized controlled pilot study

{ 'indexed': {'date-parts': [[2024, 5, 4]], 'date-time': '2024-05-04T01:37:09Z', 'timestamp': 1714786629793}, 'reference-count': 20, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 9, 15]], 'date-time': '2022-09-15T00:00:00Z', 'timestamp': 1663200000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2022, 9, 15]], 'date-time': '2022-09-15T00:00:00Z', 'timestamp': 1663200000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2022, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>This pilot study included 68 cases with post-COVID-19 persistent ' 'cough (&gt; 8 weeks), randomly allocated into two groups; intervention group (32 patients) ' 'received standard cough therapy, and montelukast 10 mg/day for 14 days and control group (36 ' 'patients) received only cough sedatives.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>We found a significant improvement in the number of cough ' 'paroxysms/day, cough severity visual analog scale, cough severity index and cough quality of ' 'life, shorter duration improvement, and minimal side effects in the interventional ' 'group.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>We suggest that montelukast may be effective to reduce the duration ' 'and severity of the persistent post-COVID-19 cough and further improve quality of ' 'life.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s43168-022-00154-6', 'type': 'journal-article', 'created': {'date-parts': [[2022, 9, 15]], 'date-time': '2022-09-15T12:07:37Z', 'timestamp': 1663243657000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 6, 'title': 'Value of montelukast as a potential treatment of post-COVID-19 persistent cough: a ' 'non-randomized controlled pilot study', 'prefix': '10.1186', 'volume': '16', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-7111-2195', 'authenticated-orcid': False, 'given': 'Aliae A. R.', 'family': 'Mohamed Hussein', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6068-5724', 'authenticated-orcid': False, 'given': 'Mohamed Eltaher A. A.', 'family': 'Ibrahim', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0001-6002-6796', 'authenticated-orcid': False, 'given': 'Hoda A.', 'family': 'Makhlouf', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-2949-4369', 'authenticated-orcid': False, 'given': 'Nahed A.', 'family': 'Makhlouf', 'sequence': 'additional', 'affiliation': []}, {'given': 'Howaida K.', 'family': 'Abd-Elaal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Karima M. S.', 'family': 'Kholief', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-0844-4215', 'authenticated-orcid': False, 'given': 'Islam G.', 'family': 'Sayed', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 9, 15]]}, 'reference': [ { 'issue': '6', 'key': '154_CR1', 'doi-asserted-by': 'publisher', 'first-page': '603', 'DOI': '10.1001/jama.2020.12603', 'volume': '324', 'author': 'A Carfì', 'year': '2020', 'unstructured': 'Carfì A, Bernabei R, Landi F (2020) For the gemelli against COVID-19 ' 'post-acute care study group. Persistent symptoms in patients after acute ' 'COVID-19. JAMA. 324(6):603–605. https://doi.org/10.1001/jama.2020.12603', 'journal-title': 'JAMA.'}, { 'key': '154_CR2', 'doi-asserted-by': 'crossref', 'unstructured': 'Galal I, Hussein AA, Amin MT, Saad MM, Zayan HEE, Abdelsayed M Z, ... & ' 'Hashem M. K (2021) Determinants of persistent post-COVID-19 symptoms: ' 'value of a novel COVID-19 symptom score. Egypt J Bronchol 15(1):1–8', 'DOI': '10.1186/s43168-020-00049-4'}, { 'issue': '11', 'key': '154_CR3', 'doi-asserted-by': 'publisher', 'first-page': '4413', 'DOI': '10.1021/acs.jpclett.0c00994', 'volume': '11', 'author': 'T Huynh', 'year': '2020', 'unstructured': 'Huynh T, Wang H, Luan B (2020) In silico exploration of the molecular ' 'mechanism of clinically oriented drugs for possibly inhibiting ' 'SARS-CoV-2’s main protease. J Phys Chem Lett 11(11):4413–4420', 'journal-title': 'J Phys Chem Lett'}, { 'issue': '3', 'key': '154_CR4', 'doi-asserted-by': 'publisher', 'first-page': '232', 'DOI': '10.1016/S1081-1206(10)61493-7', 'volume': '93', 'author': 'SL Spector', 'year': '2004', 'unstructured': 'Spector SL, Tan RA (2004) Effectiveness of montelukast in the treatment ' 'of cough variant asthma. Ann Allergy Asthma Immunol 93(3):232–236', 'journal-title': 'Ann Allergy Asthma Immunol'}, { 'issue': '12', 'key': '154_CR5', 'doi-asserted-by': 'publisher', 'first-page': '1790', 'DOI': '10.1016/j.rmed.2011.08.007', 'volume': '105', 'author': 'DG Peroni', 'year': '2011', 'unstructured': 'Peroni DG, Pescollderungg L, Sandri M, Chinellato I, Boner AL, ' 'Piacentini GL (2011) Time-effect of montelukast on protection against ' 'exercise-induced bronchoconstriction. Respir Med 105(12):1790–1797', 'journal-title': 'Respir Med'}, { 'key': '154_CR6', 'first-page': '2067', 'volume': '22', 'author': 'LQ Zhu', 'year': '2011', 'unstructured': 'Zhu LQ, Kuang JL, Deng ZC (2011) Clinical analysis of montelukast in the ' 'treatment of post-infectious cough. China Pharmacy 22:2067–2069', 'journal-title': 'China Pharmacy'}, { 'issue': '8', 'key': '154_CR7', 'doi-asserted-by': 'publisher', 'first-page': '854', 'DOI': '10.1164/rccm.200706-910OC', 'volume': '178', 'author': 'H Bisgaard', 'year': '2008', 'unstructured': 'Bisgaard H, Flores-Nunez A, Goh A, Azimi P, Halkas A, Malice MP, Marchal ' 'JL, Dass SB, Reiss TF, Knorr BA (2008) Study of montelukast for the ' 'treatment of respiratory symptoms of post–respiratory syncytial virus ' 'bronchiolitis in children. Am J Respir Crit Care Med 178(8):854–860', 'journal-title': 'Am J Respir Crit Care Med'}, { 'key': '154_CR8', 'doi-asserted-by': 'publisher', 'first-page': '1344', 'DOI': '10.3389/fphar.2020.01344', 'volume': '11', 'author': 'J Barré', 'year': '2020', 'unstructured': 'Barré J, Sabatier JM, Annweiler C (2020) Montelukast drug may improve ' 'COVID-19 prognosis: a review of evidence. Front Pharmacol 11:1344', 'journal-title': 'Front Pharmacol'}, { 'key': '154_CR9', 'unstructured': 'Assaf G, Davis H, McCorkell L et al (2020) An analysis of the prolonged ' 'COVID-19 symptoms survey by patient-led research team. Patient Led Res ' 'https://patientresearchcovid19.com/'}, { 'key': '154_CR10', 'volume-title': 'British Thoracic Society guidance on respiratory follow up of patients ' 'with a clinico-radiological diagnosis of COVID-19 pneumonia', 'author': 'British Thoracic Society', 'year': '2020', 'unstructured': 'British Thoracic Society (2020) British Thoracic Society guidance on ' 'respiratory follow up of patients with a clinico-radiological diagnosis ' 'of COVID-19 pneumonia ' 'https://www.brit-thoracic.org.uk/document-library/quality-improvement/covid-19/resp-follow-up-guidance-post-covid-pneumonia/'}, { 'key': '154_CR11', 'volume-title': 'Post COVID-19 patient information pack', 'author': 'Homerton University Hospital', 'year': '2020', 'unstructured': 'Homerton University Hospital (2020) Post COVID-19 patient information ' 'pack ' 'https://www.hackneycitizen.co.uk/wp-content/uploads/Post-COVID-19-information-pack-5.pdf'}, { 'key': '154_CR12', 'doi-asserted-by': 'publisher', 'unstructured': 'Shembel AC, Rosen CA, Zullo TG, Gartner-Schmidt JL (2013) Development ' 'and validation of the cough severity index: a severity index for chronic ' 'cough related to the upper airway. Laryngoscope. ' 'https://doi.org/10.1002/lary.23916', 'DOI': '10.1002/lary.23916'}, { 'key': '154_CR13', 'doi-asserted-by': 'publisher', 'first-page': '1123', 'DOI': '10.1378/chest.121.4.1123', 'volume': '121', 'author': 'C French', 'year': '2002', 'unstructured': 'French C, Irwin RS, Fletcher KE et al (2002) Evaluation of a ' 'cough-specific quality-of-life questionnaire. Chest. 121:1123–1131', 'journal-title': 'Chest.'}, { 'issue': '1', 'key': '154_CR14', 'first-page': '35', 'volume': '2', 'author': 'K Wang', 'year': '2014', 'unstructured': 'Wang K, Birring SS, Taylor K, Fry NK, Hay AD, Moore M, Jin J, Perera R, ' 'Farmer A, Little P, Harrison TG (2014) Montelukast for postinfectious ' 'cough in adults: a double-blind randomised placebo-controlled trial. The ' 'lancet. Respir Med 2(1):35–43', 'journal-title': 'Respir Med'}, { 'issue': '1', 'key': '154_CR15', 'doi-asserted-by': 'publisher', 'first-page': '147', 'DOI': '10.1183/09031936.04.00053604', 'volume': '25', 'author': 'BP Ponsioen', 'year': '2005', 'unstructured': 'Ponsioen BP, Hop WC, Vermue NA, Dekhuijzen PN, Bohnen AM (2005) Efficacy ' 'of fluticasone on cough: a randomised controlled trial. Eur Respir J ' '25(1):147–152', 'journal-title': 'Eur Respir J'}, { 'issue': '1', 'key': '154_CR16', 'doi-asserted-by': 'publisher', 'first-page': '47', 'DOI': '10.1007/s00408-009-9197-8', 'volume': '188', 'author': 'A Woodcock', 'year': '2010', 'unstructured': 'Woodcock A, McLeod RL, Sadeh J, Smith JA (2010) The efficacy of a NOP1 ' 'agonist (SCH486757) in subacute cough. Lung. 188(1):47–52', 'journal-title': 'Lung.'}, { 'key': '154_CR17', 'doi-asserted-by': 'publisher', 'unstructured': 'Bozek A, Winterstein J (2020) Montelukast’s ability to fight COVID-19 ' 'infection. J Asthma 1–2. https://doi.org/10.1080/02770903.2020.1786112', 'DOI': '10.1080/02770903.2020.1786112'}, { 'key': '154_CR18', 'doi-asserted-by': 'publisher', 'first-page': '109828', 'DOI': '10.1016/j.mehy.2020.109828', 'volume': '142', 'author': 'C Fidan', 'year': '2020', 'unstructured': 'Fidan C, Aydoğdu A (2020) As a potential treatment of COVID-19: ' 'montelukast. Med Hypotheses 142:109828. ' 'https://doi.org/10.1016/j.mehy.2020.109828 Epub 2020 May 11. PMID: ' '32416408; PMCID: PMC7211747', 'journal-title': 'Med Hypotheses'}, { 'key': '154_CR19', 'doi-asserted-by': 'publisher', 'first-page': '3079', 'DOI': '10.3389/fmicb.2019.03079', 'volume': '10', 'author': 'Y Chen', 'year': '2020', 'unstructured': 'Chen Y, Li Y, Wang X, Zou P (2020) Montelukast, an anti-asthmatic drug, ' 'inhibits Zika virus infection by disrupting viral integrity. Front ' 'Microbiol 10:3079', 'journal-title': 'Front Microbiol'}, { 'key': '154_CR20', 'doi-asserted-by': 'crossref', 'unstructured': 'Ruiz I, Nevers Q, Hernández E, Ahnou N, Brillet R, Softic L, ... & ' 'Ahmed-Belkacem A (2020) MK-571, a cysteinyl leukotriene receptor 1 ' 'antagonist, inhibits hepatitis C virus replication.\xa0Antimicrob Agents ' 'Chemother 64(6):e02078–19', 'DOI': '10.1128/AAC.02078-19'}], 'container-title': 'The Egyptian Journal of Bronchology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s43168-022-00154-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s43168-022-00154-6/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s43168-022-00154-6.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2022, 9, 15]], 'date-time': '2022-09-15T12:11:37Z', 'timestamp': 1663243897000}, 'score': 1, 'resource': {'primary': {'URL': 'https://ejb.springeropen.com/articles/10.1186/s43168-022-00154-6'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 9, 15]]}, 'references-count': 20, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2022, 12]]}}, 'alternative-id': ['154'], 'URL': 'http://dx.doi.org/10.1186/s43168-022-00154-6', 'relation': {}, 'ISSN': ['1687-8426', '2314-8551'], 'subject': [], 'container-title-short': 'Egypt J Bronchol', 'published': {'date-parts': [[2022, 9, 15]]}, 'assertion': [ { 'value': '27 June 2022', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '28 August 2022', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '15 September 2022', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'The Research Ethics Committee at the Faculty of Medicine, Aswan University, has ' 'approved the study (IRB number: aswu/469/7/2020), and all patients provided ' 'written informed consent before participation.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'The manuscript has been read and approved by all the authors.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare that they have no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '52'}