Clinical efficacy of casirivimab-imdevimab antibody combination treatment in patients with COVID-19 Delta variant
et al., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2022.05.012
, Clinical efficacy of casirivimab-imdevimab antibody combination treatment in patients with COVID-19 Delta.., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2022.05.012
Retrospective 461 patients treated with casirivimab/imdevimab in Japan, and 461 matched controls, showing lower oxygen requirements with treatment.Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan].
1.
Liu et al., bioRxiv, doi:10.1101/2021.12.14.472719,
Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2,
https://www.biorxiv.org/content/10.1101/2021.12.14.472719.
2.
Sheward et al., bioRxiv, doi:10.1101/2021.12.19.473354,
Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron),
https://www.biorxiv.org/content/10.1101/2021.12.19.473354.
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risk of mechanical ventilation, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 461 (0.4%), control 3 of 461 (0.7%), NNT 461.
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risk of oxygen therapy, 46.4% lower, RR 0.54, p = 0.004, treatment 30 of 461 (6.5%), control 56 of 461 (12.1%), NNT 18.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Miyashita et al., 26 May 2022, retrospective, Japan, peer-reviewed, 6 authors, average treatment delay 4.0 days.
Clinical efficacy of casirivimab-imdevimab antibody combination treatment in patients with COVID-19 Delta variant
Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2022.05.012
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Conflicts of interest The authors declare that they have no conflicts of interest.
Author's contributions: All the authors conceived the study, participated in its design and coordination and collected and managed the data, including quality control. NM and YN drafted the manuscript, and all authors contributed substantially to its revision. All the authors read and approved the final manuscript.
Ethical approval and consent to participate J o u r n a l P r e -p r o o f
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