Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lactoferrin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Vitamins
More

Other
Feedback
Home
Top
Abstract
All antiandrogen studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchAntiandrogenAntiandrogens (more..)
Melatonin Meta
Azvudine Meta Metformin Meta
Bromhexine Meta
Budesonide Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Famotidine Meta Nitazoxanide Meta
Favipiravir Meta Paxlovid Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  

Protective trend of anti-androgen therapy during the COVID-19 pandemic: A meta-analysis

Meng et al., Journal of Infection, doi:10.1016/j.jinf.2022.03.020
Mar 2022  
  Twitter
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Meta analysis of 15 antiandrogen studies showing a protective trend although there has been conflicting results to date.
2 meta analyses show significant improvements with antiandrogens for mortality Cheema, Kotani, hospitalization Cheema, recovery Cheema, and progression Kotani.
Currently there are 49 antiandrogens for COVID-19 studies, showing 38% lower mortality [22‑51%], 47% lower ventilation [23‑64%], 36% lower ICU admission [6‑56%], 30% lower hospitalization [9‑47%], and 8% fewer cases [1‑15%].
Meng et al., 31 Mar 2022, peer-reviewed, 11 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperAntiandrogensAll
Protective trend of anti-androgen therapy during the COVID-19 pandemic: A meta-analysis
Jialin Meng, Qintao Ge, Jiawei Li, Xiaofan Lu, Yonghao Chen, Haitao Wang, Meng Zhang, Juan Du, Li Zhang, Zongyao Hao, Chaozhao Liang
Journal of Infection, doi:10.1016/j.jinf.2022.03.020
Protective trend of anti-androgen therapy during the COVID-19 pandemic: A meta-analysis Dear editor, Androgen receptor (AR) is an important transcription factor; thus, androgen and AR-associated pathways play pivotal roles in the progression of several diseases, including prostate cancer (PCa), benign prostatic hyperplasia (BPH), breast cancer, acne, and alopecia [ 1 , 2 ]. Anti-androgen therapy is widely used for the clinical treatment of prostatic diseases, including androgen deprivation therapy (ADT) via surgical castration, pharmacological castration,
Declaration of Competing Interest The authors have no conflicts of interest to declare. Supplementary materials Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.jinf.2022.03.020 .
References
Deng, Rasool, Russell, Natesan, Asangani, Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19, iScience
Leach, Mohr, Giotis, Cil, Isac et al., The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells, Nat Commun
Lyon, Li, Cullen, Milinovich, Kattan et al., 5alpha-reductase inhibitors are associated with reduced risk of SARS-CoV-2 infection: a matchedpair, registry-based analysis, J Urol
Marks, Prasad, Souza, Burns, Senna, Topical antiandrogen therapies for androgenetic alopecia and acne vulgaris, Am J Clin Dermatol
Montopoli, Zumerle, Vettor, Rugge, Zorzi et al., Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532), Ann Oncol
Qiao, Wang, Mannan, Pitchiaya, Zhang et al., Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2, Proc Natl Acad Sci
Shukla, Plaga, Shankar, Gupta, Androgen receptor-related diseases: what do we know?, Andrology
Welen, Rosendal, Gisslen, Lenman, Freyhult et al., A phase 2 trial of the effect of antiandrogen therapy on COVID-19 Outcome: No evidence of benefit, supported by epidemiology and in vitro data, Eur Urol
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of over 100,000 datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit