Antiandrogens for the treatment of COVID‐19 patients: A meta‐analysis of randomized controlled trials

{ 'indexed': {'date-parts': [[2023, 4, 19]], 'date-time': '2023-04-19T05:36:31Z', 'timestamp': 1681882591366}, 'reference-count': 32, 'publisher': 'Wiley', 'issue': '4', 'license': [ { 'start': { 'date-parts': [[2023, 4, 18]], 'date-time': '2023-04-18T00:00:00Z', 'timestamp': 1681776000000}, 'content-version': 'vor', 'delay-in-days': 17, 'URL': 'http://onlinelibrary.wiley.com/termsAndConditions#vor'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'published-print': {'date-parts': [[2023, 4]]}, 'DOI': '10.1002/jmv.28740', 'type': 'journal-article', 'created': {'date-parts': [[2023, 4, 18]], 'date-time': '2023-04-18T12:41:07Z', 'timestamp': 1681821667000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Antiandrogens for the treatment of COVID‐19 patients: A meta‐analysis of randomized controlled ' 'trials', 'prefix': '10.1002', 'volume': '95', 'author': [ { 'given': 'Huzaifa Ahmad', 'family': 'Cheema', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Medicine, Division of Infectious Diseases King ' 'Edward Medical University Lahore Pakistan'}]}, { 'ORCID': 'http://orcid.org/0000-0002-3795-8998', 'authenticated-orcid': False, 'given': 'Aqeeb Ur', 'family': 'Rehman', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Division of Infectious Diseases King ' 'Edward Medical University Lahore Pakistan'}]}, { 'given': 'Asmaa Ahmed', 'family': 'Elrashedy', 'sequence': 'additional', 'affiliation': [ { 'name': 'Faculty of Medicine Kafr El‐Shaikh University Kafr El‐Shaikh ' 'Egypt'}]}, { 'given': 'Aleenah', 'family': 'Mohsin', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Division of Infectious Diseases King ' 'Edward Medical University Lahore Pakistan'}]}, { 'given': 'Abia', 'family': 'Shahid', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Division of Infectious Diseases King ' 'Edward Medical University Lahore Pakistan'}]}, { 'ORCID': 'http://orcid.org/0000-0002-6021-2342', 'authenticated-orcid': False, 'given': 'Muhammad', 'family': 'Ehsan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Division of Infectious Diseases King ' 'Edward Medical University Lahore Pakistan'}]}, { 'given': 'Muhammad', 'family': 'Ayyan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Medicine, Division of Infectious Diseases King ' 'Edward Medical University Lahore Pakistan'}]}, { 'given': 'Heba', 'family': 'Ismail', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Internal Medicine Limerick University Hospital ' 'Limerick Ireland'}]}, { 'given': 'Talal', 'family': 'Almas', 'sequence': 'additional', 'affiliation': [{'name': 'Galway University Hospital Galway Ireland'}]}], 'member': '311', 'published-online': {'date-parts': [[2023, 4, 18]]}, 'reference': [ {'key': 'e_1_2_8_2_1', 'doi-asserted-by': 'publisher', 'DOI': '10.37201/req/158.2021'}, {'key': 'e_1_2_8_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ejim.2022.05.024'}, {'key': 'e_1_2_8_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jmv.28471'}, {'key': 'e_1_2_8_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/ptr.7724'}, {'key': 'e_1_2_8_6_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/rmv.2427'}, { 'key': 'e_1_2_8_7_1', 'doi-asserted-by': 'crossref', 'first-page': '154', 'DOI': '10.1016/j.jinf.2022.11.022', 'article-title': 'No evidence of clinical efficacy of famotidine for the treatment of ' 'COVID‐19 in a systematic review and meta‐analysis', 'volume': '86', 'author': 'Cheema HA', 'year': '2022', 'journal-title': 'J Infect'}, { 'issue': '6', 'key': 'e_1_2_8_8_1', 'doi-asserted-by': 'crossref', 'first-page': '702', 'DOI': '10.1016/j.jinf.2022.10.012', 'article-title': 'Efficacy and safety of fluvoxamine for the treatment of COVID‐19 ' 'patients: a systematic review and meta‐analysis', 'volume': '85', 'author': 'Cheema HA', 'year': '2022', 'journal-title': 'J Infect'}, { 'key': 'e_1_2_8_9_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/jclinpath-2020-206987'}, {'key': 'e_1_2_8_10_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.n71'}, {'key': 'e_1_2_8_11_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.l4898'}, { 'issue': '4', 'key': 'e_1_2_8_12_1', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1210/jendso/bvac017', 'article-title': 'A randomized trial of sitagliptin and spironolactone with combination ' 'therapy in hospitalized adults with COVID‐19', 'volume': '6', 'author': 'Abbasi F', 'year': '2022', 'journal-title': 'J Endocr Soc'}, { 'issue': '9', 'key': 'e_1_2_8_13_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1056/EVIDoa2200145', 'article-title': 'Oral sabizabulin for high‐risk, hospitalized adults with Covid‐19: ' 'interim analysis', 'volume': '1', 'author': 'Barnette KG', 'year': '2022', 'journal-title': 'NEJM Evid'}, { 'issue': '3', 'key': 'e_1_2_8_14_1', 'doi-asserted-by': 'crossref', 'first-page': '285', 'DOI': '10.1016/j.eururo.2021.12.013', 'article-title': 'A phase 2 trial of the effect of antiandrogen therapy on COVID‐19 ' 'outcome: no evidence of benefit, supported by epidemiology and in vitro ' 'data', 'volume': '81', 'author': 'Welén K', 'year': '2022', 'journal-title': 'Eur Urol'}, { 'issue': '1', 'key': 'e_1_2_8_15_1', 'article-title': 'Finasteride in hospitalized adult males with COVID‐19: a risk factor ' 'for severity of the disease or an adjunct treatment: a randomized ' 'controlled clinical trial', 'volume': '35', 'author': 'Zarehoseinzade E', 'year': '2021', 'journal-title': 'Med J Islam Repub Iran'}, { 'key': 'e_1_2_8_16_1', 'unstructured': 'NCT04870606. Proxalutamide (GT0918) treatment for outpatients with mild ' 'or moderate COVID‐19 illnessClinicalTrials.gov.2022. Accessed March 8 ' '2023.https://www.prnewswire.com/news-releases/kintor-pharmas-proxalutamide-demonstrated-reduction-in-hospitalizationmortality-for-patients-with-mild-to-moderate-covid-19-in-phase-iii-mrct-study-301518525.html'}, { 'key': 'e_1_2_8_17_1', 'unstructured': 'Veru Inc. COVID‐19 Treatment of Severe Acute Respiratory Syndrome With ' 'Veru‐111.ClinicalTrials.gov.2021. Accessed March 8 ' '2023.https://clinicaltrials.gov/ct2/show/results/NCT04388826'}, { 'key': 'e_1_2_8_18_1', 'article-title': 'Proxalutamide (GT0918) reduces the rate of hospitalization in ' 'mild‐to‐moderate COVID‐19 female patients: a randomized double‐blinded ' 'placebo‐controlled two‐arm parallel trial', 'author': 'Adsuara Cadegiani F', 'year': '2021', 'journal-title': 'medRxiv'}, { 'issue': '12', 'key': 'e_1_2_8_19_1', 'article-title': 'Final results of a randomized, placebo‐controlled, two‐arm, parallel ' 'clinical trial of proxalutamide for hospitalized COVID‐19 patients: a ' 'multiregional, joint analysis of the proxa‐rescue AndroCoV trial', 'volume': '13', 'author': 'Cadegiani FA', 'year': '2021', 'journal-title': 'Cureus'}, { 'issue': '2', 'key': 'e_1_2_8_20_1', 'article-title': 'Early antiandrogen therapy with dutasteride reduces viral shedding, ' 'inflammatory responses, and time‐to‐remission in males with COVID‐19: a ' 'randomized, double‐blind, placebo‐controlled interventional trial ' '(EAT‐DUTA AndroCoV trial–biochemical)', 'volume': '13', 'author': 'Cadegiani FA', 'year': '2021', 'journal-title': 'Cureus'}, { 'key': 'e_1_2_8_21_1', 'article-title': '13 cis retinoic acid improved the outcomes of COVID‐19 patients. A ' 'randomized clinical trial', 'author': 'Elkazzaz M', 'year': '2022', 'journal-title': 'medRxiv'}, { 'issue': '2', 'key': 'e_1_2_8_22_1', 'article-title': 'Mineralocorticoid receptor antagonist (potassium canrenoate) does not ' 'influence outcome in the treatment of COVID‐19‐associated pneumonia and ' 'Fibrosis—a randomized placebo controlled clinical trial', 'volume': '15', 'author': 'Kotfis K', 'year': '2022', 'journal-title': 'Pharm'}, { 'key': 'e_1_2_8_23_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.eclinm.2022.101450'}, { 'key': 'e_1_2_8_24_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamanetworkopen.2022.7852'}, { 'key': 'e_1_2_8_25_1', 'article-title': 'Phase 2 randomised placebo‐controlled trial of spironolactone and ' 'dexamethasone versus dexamethasone in COVID‐19 hospitalised patients in ' 'Delhi', 'author': 'Wadhwa B', 'year': '2022', 'journal-title': 'medRxiv'}, {'key': 'e_1_2_8_26_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1530/ERC-20-0165'}, {'key': 'e_1_2_8_27_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s00345-021-03810-6'}, { 'key': 'e_1_2_8_28_1', 'first-page': '577', 'article-title': 'Effects of androgen deprivation therapy on COVID‐19 in patients with ' 'prostate cancer: a systematic review and meta‐analysis', 'volume': '18', 'author': 'Karimi A', 'year': '2021', 'journal-title': 'Urol J'}, {'key': 'e_1_2_8_29_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jinf.2022.03.020'}, {'key': 'e_1_2_8_30_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.coi.2009.05.023'}, {'key': 'e_1_2_8_31_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/cid/ciaa1022'}, { 'key': 'e_1_2_8_32_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/bs.apcsb.2019.01.001'}, {'key': 'e_1_2_8_33_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1093/biolre/ioy043'}], 'container-title': 'Journal of Medical Virology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.28740', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 4, 18]], 'date-time': '2023-04-18T12:41:21Z', 'timestamp': 1681821681000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1002/jmv.28740'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 4]]}, 'references-count': 32, 'journal-issue': {'issue': '4', 'published-print': {'date-parts': [[2023, 4]]}}, 'alternative-id': ['10.1002/jmv.28740'], 'URL': 'http://dx.doi.org/10.1002/jmv.28740', 'relation': {}, 'ISSN': ['0146-6615', '1096-9071'], 'subject': ['Infectious Diseases', 'Virology'], 'container-title-short': 'Journal of Medical Virology', 'published': {'date-parts': [[2023, 4]]}}