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All Studies   Meta Analysis       

Antiandrogens for the treatment of COVID‐19 patients: A meta‐analysis of randomized controlled trials

Cheema et al., Journal of Medical Virology, doi:10.1002/jmv.28740
Apr 2023  
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Mortality 63% Improvement Relative Risk Antiandrogens  Cheema et al.  META ANALYSIS c19early.org Favorsantiandrogens Favorscontrol 0 0.5 1 1.5 2+
7th treatment shown to reduce risk in September 2020, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments.
5,300+ studies for 115 treatments. c19early.org
Meta analysis of 14 antiandrogen RCTs for COVID-19, showing significantly lower mortality with treatment.
2 meta analyses show significant improvements with antiandrogens for mortality1,2, hospitalization2, recovery2, and progression1.
Currently there are 49 antiandrogens for COVID-19 studies, showing 37% lower mortality [21‑50%], 47% lower ventilation [23‑64%], 36% lower ICU admission [5‑57%], 32% lower hospitalization [11‑48%], and 8% fewer cases [1‑14%].
risk of death, 63.0% lower, RR 0.37, p < 0.001.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cheema et al., 18 Apr 2023, peer-reviewed, 9 authors.
This PaperAntiandrogensAll
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spironolactone with combination therapy in hospitalized adults with COVID‐19", "author": "Abbasi F", "doi-asserted-by": "crossref", "first-page": "1", "issue": "4", "journal-title": "J Endocr Soc", "key": "e_1_2_8_12_1", "volume": "6", "year": "2022" }, { "DOI": "10.1056/EVIDoa2200145", "article-title": "Oral sabizabulin for high‐risk, hospitalized adults with Covid‐19: interim analysis", "author": "Barnette KG", "doi-asserted-by": "crossref", "issue": "9", "journal-title": "NEJM Evid", "key": "e_1_2_8_13_1", "volume": "1", "year": "2022" }, { "DOI": "10.1016/j.eururo.2021.12.013", "article-title": "A phase 2 trial of the effect of antiandrogen therapy on COVID‐19 outcome: no evidence of benefit, supported by epidemiology and in vitro data", "author": "Welén K", "doi-asserted-by": "crossref", "first-page": "285", "issue": "3", "journal-title": "Eur Urol", "key": "e_1_2_8_14_1", "volume": "81", "year": "2022" }, { "article-title": "Finasteride in hospitalized adult males with COVID‐19: a risk factor for severity of the disease or an adjunct treatment: a randomized controlled clinical trial", "author": "Zarehoseinzade E", "issue": "1", "journal-title": "Med J Islam Repub Iran", "key": "e_1_2_8_15_1", "volume": "35", "year": "2021" }, { "key": "e_1_2_8_16_1", "unstructured": "NCT04870606. Proxalutamide (GT0918) treatment for outpatients with mild or moderate COVID‐19 illnessClinicalTrials.gov.2022. Accessed March 8 2023.https://www.prnewswire.com/news-releases/kintor-pharmas-proxalutamide-demonstrated-reduction-in-hospitalizationmortality-for-patients-with-mild-to-moderate-covid-19-in-phase-iii-mrct-study-301518525.html" }, { "key": "e_1_2_8_17_1", "unstructured": "Veru Inc. COVID‐19 Treatment of Severe Acute Respiratory Syndrome With Veru‐111.ClinicalTrials.gov.2021. Accessed March 8 2023.https://clinicaltrials.gov/ct2/show/results/NCT04388826" }, { "article-title": "Proxalutamide (GT0918) reduces the rate of hospitalization in mild‐to‐moderate COVID‐19 female patients: a randomized double‐blinded placebo‐controlled two‐arm parallel trial", "author": "Adsuara Cadegiani F", "journal-title": "medRxiv", "key": "e_1_2_8_18_1", "year": "2021" }, { "article-title": "Final results of a randomized, placebo‐controlled, two‐arm, parallel clinical trial of proxalutamide for hospitalized COVID‐19 patients: a multiregional, joint analysis of the proxa‐rescue AndroCoV trial", "author": "Cadegiani FA", "issue": "12", "journal-title": "Cureus", "key": "e_1_2_8_19_1", "volume": "13", "year": "2021" }, { "article-title": "Early antiandrogen therapy with dutasteride reduces viral shedding, inflammatory responses, and time‐to‐remission in males with COVID‐19: a randomized, double‐blind, placebo‐controlled interventional trial (EAT‐DUTA AndroCoV trial–biochemical)", "author": "Cadegiani FA", "issue": "2", "journal-title": "Cureus", "key": "e_1_2_8_20_1", "volume": "13", "year": "2021" }, { "article-title": "13 cis retinoic acid improved the outcomes of COVID‐19 patients. A randomized clinical trial", "author": "Elkazzaz M", "journal-title": "medRxiv", "key": "e_1_2_8_21_1", "year": "2022" }, { "article-title": "Mineralocorticoid receptor antagonist (potassium canrenoate) does not influence outcome in the treatment of COVID‐19‐associated pneumonia and Fibrosis—a randomized placebo controlled clinical trial", "author": "Kotfis K", "issue": "2", "journal-title": "Pharm", "key": "e_1_2_8_22_1", "volume": "15", "year": "2022" }, { "DOI": "10.1016/j.eclinm.2022.101450", "doi-asserted-by": "publisher", "key": "e_1_2_8_23_1" }, { "DOI": "10.1001/jamanetworkopen.2022.7852", "doi-asserted-by": "publisher", "key": "e_1_2_8_24_1" }, { "article-title": "Phase 2 randomised placebo‐controlled trial of spironolactone and dexamethasone versus dexamethasone in COVID‐19 hospitalised patients in Delhi", "author": "Wadhwa B", "journal-title": "medRxiv", "key": "e_1_2_8_25_1", "year": "2022" }, { "DOI": "10.1530/ERC-20-0165", "doi-asserted-by": "publisher", "key": "e_1_2_8_26_1" }, { "DOI": "10.1007/s00345-021-03810-6", "doi-asserted-by": "publisher", "key": "e_1_2_8_27_1" }, { "article-title": "Effects of androgen deprivation therapy on COVID‐19 in patients with prostate cancer: a systematic review and meta‐analysis", "author": "Karimi A", "first-page": "577", "journal-title": "Urol J", "key": "e_1_2_8_28_1", "volume": "18", "year": "2021" }, { "DOI": "10.1016/j.jinf.2022.03.020", "doi-asserted-by": "publisher", "key": "e_1_2_8_29_1" }, { "DOI": "10.1016/j.coi.2009.05.023", "doi-asserted-by": "publisher", "key": "e_1_2_8_30_1" }, { "DOI": "10.1093/cid/ciaa1022", "doi-asserted-by": "publisher", "key": "e_1_2_8_31_1" }, { "DOI": "10.1016/bs.apcsb.2019.01.001", "doi-asserted-by": "publisher", "key": "e_1_2_8_32_1" }, { "DOI": "10.1093/biolre/ioy043", "doi-asserted-by": "publisher", "key": "e_1_2_8_33_1" } ], "reference-count": 32, "references-count": 32, "relation": {}, "resource": { "primary": { "URL": "https://onlinelibrary.wiley.com/doi/10.1002/jmv.28740" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Infectious Diseases", "Virology" ], "subtitle": [], "title": "Antiandrogens for the treatment of COVID‐19 patients: A meta‐analysis of randomized controlled trials", "type": "journal-article", "volume": "95" }
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