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Antiandrogens for the treatment of COVID‐19 patients: A meta‐analysis of randomized controlled trials

Cheema et al., Journal of Medical Virology, doi:10.1002/jmv.28740

Apr 2023

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Antiandrogens

7th treatment shown to reduce risk in September 2020

^*, now known with p = 0.000000056 from 49 studies.

Lower risk for mortality, ventilation, ICU admission, hospitalization, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,000+ studies for 60+ treatments. c19early.org

Meta analysis of 14 antiandrogen RCTs for COVID-19, showing significantly lower mortality with treatment.

2 meta analyses show significant improvements with antiandrogens for mortality Cheema, Kotani, hospitalization Cheema, recovery Cheema, and progression Kotani.

Currently there are 49 antiandrogens for COVID-19 studies, showing 37% lower mortality [21‑50%], 47% lower ventilation [23‑64%], 36% lower ICU admission [5‑57%], 32% lower hospitalization [11‑48%], and 8% fewer cases [1‑14%].

1. Cheema et al., Antiandrogens for the treatment of COVID‐19 patients: A meta‐analysis of randomized controlled trials, Journal of Medical Virology, doi:10.1002/jmv.28740.wiley.com, doi.org.

2. Kotani et al., Antiandrogen Agents in COVID-19: A Meta-Analysis of Randomized Trials, SSRN Electronic Journal, doi:10.2139/ssrn.4181700.ssrn.com, doi.org.

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risk of death, 63.0% lower, RR 0.37, p < 0.001.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Cheema et al., 18 Apr 2023, peer-reviewed, 9 authors.

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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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