Yuki Kotani
antiandrogen agents reduced mortality at the longest follow-up available (91/946 [9•6%] vs 244/811 [30%]; risk ratio (RR) = 0•40; 95% confidence interval (CI), 0•24-0•66; P = 0•0004; low certainty of evidence; I 2 =59%). Antiandrogen therapy also reduced clinical worsening (125/941 [13%] vs 279/809 [35%]; RR = 0•47; 95% CI, 0•29-0•78; P = 0•003; low certainty of evidence; I 2 =72%). There was no significant difference in the need for invasive mechanical ventilation, admission to the intensive care unit, the need for hospitalization, or thrombotic events between the two treatment groups.
Interpretation Antiandrogen therapy reduced mortality and clinical worsening in adult patients with COVID-19.
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