Conv. Plasma
Nigella Sativa
Peg.. Lambda

All antiandrogen studies
Meta analysis
Home COVID-19 treatment researchAntiandrogenAntiandrogens (more..)
Melatonin Meta
Bromhexine Meta Metformin Meta
Budesonide Meta
Cannabidiol Meta Molnupiravir Meta
Colchicine Meta
Conv. Plasma Meta
Curcumin Meta Nigella Sativa Meta
Ensovibep Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Peg.. Lambda Meta
Fluvoxamine Meta Quercetin Meta
Hydroxychlor.. Meta Remdesivir Meta
Ivermectin Meta
Lactoferrin Meta

All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 60% Improvement Relative Risk Progression 53% Antiandrogens  Kotani et al.  META ANALYSIS Favors antiandrogen Favors control

Antiandrogen Agents in COVID-19: A Meta-Analysis of Randomized Trials

Kotani et al., SSRN Electronic Journal, doi:10.2139/ssrn.4181700
Aug 2022  
  Source   PDF   All Studies   Meta AnalysisMeta
Meta analysis of 12 studies, showing significantly lower mortality with antiandrogen treatment.
2 meta analyses show significant improvements with antiandrogens for mortality Cheema, Kotani, hospitalization Cheema, recovery Cheema, and progression Kotani.
Currently there are 49 antiandrogens for COVID-19 studies, showing 38% lower mortality [22‑51%], 47% lower ventilation [23‑64%], 36% lower ICU admission [6‑56%], 30% lower hospitalization [9‑47%], and 9% fewer cases [1‑15%].
risk of death, 60.0% lower, RR 0.40, p < 0.001.
risk of progression, 53.0% lower, RR 0.47, p = 0.003.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kotani et al., 4 Aug 2022, preprint, 9 authors.
All Studies   Meta Analysis   Submit Updates or Corrections
This PaperAntiandrogensAll
Yuki Kotani
antiandrogen agents reduced mortality at the longest follow-up available (91/946 [9•6%] vs 244/811 [30%]; risk ratio (RR) = 0•40; 95% confidence interval (CI), 0•24-0•66; P = 0•0004; low certainty of evidence; I 2 =59%). Antiandrogen therapy also reduced clinical worsening (125/941 [13%] vs 279/809 [35%]; RR = 0•47; 95% CI, 0•29-0•78; P = 0•003; low certainty of evidence; I 2 =72%). There was no significant difference in the need for invasive mechanical ventilation, admission to the intensive care unit, the need for hospitalization, or thrombotic events between the two treatment groups. Interpretation Antiandrogen therapy reduced mortality and clinical worsening in adult patients with COVID-19.
Abbasi, Adatorwovor, Davarpanah, A Randomized Trial of Sitagliptin and Spironolactone With Combination Therapy in Hospitalized Adults With COVID-19, J Endocr Soc
Barnette, Gordon, Rodriguez, Oral Sabizabulin for High-Risk, Hospitalized Adults with Covid-19: Interim Analysis, NEJM Evidence
Cadegiani, Mccoy, Wambier, Goren, Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial -Biochemical), Cureus
Cadegiani, Zimerman, Fonseca, Final Results of a
Dambha-Miller, Hinton, Wilcox, Joy, Feher et al., Mortality in COVID-19 among women on hormone replacement therapy: a retrospective cohort study, Family Practice
Davey, Grossmann, Androgen Receptor Structure, Function and Biology: From Bench to Bedside, Clin Biochem Rev
Deng, Ru, Russell, Natesan, Asangani, Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19
Elkazzaz, Abo-Amer, Haydara, 13 cis retinoic acid improved the outcomes of COVID-19 patients. A randomized clinical trial, medRxiv
Ghandehari, Matusov, Pepkowitz, Controlled Pilot Trial
Guyatt, Oxman, Vist, GRADE: an emerging consensus on rating quality of evidence and strength of recommendations, BMJ
Hoffmann, Kleine-Weber, Schroeder, SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell
Huang, Li, Gu, Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study, The Lancet Respiratory Medicine
Lakbar, Luque-Paz, Mege, Einav, Leone, COVID-19 gender susceptibility and outcomes: A systematic review, PLoS One
Lyon, Li, Cullen, 5α-Reductase Inhibitors Are Associated with Reduced Risk of SARS-CoV-2 Infection: A Matched-Pair, Registry-Based Analysis, J Urol
Meng, Ge, Li, Protective trend of anti-androgen therapy during the COVID-19 pandemic: A meta-analysis, The Journal of infection
Montopoli, Zumerle, Vettor, Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532), Annals of oncology : official journal of the European Society for Medical Oncology
Nguyen, Chinn, De Ferrante, Kirby, Hohmann et al., Male gender is a predictor of higher mortality in hospitalized adults with COVID-19, PLoS One
Nicastri, Marinangeli, Pivetta, A phase 2 randomized, doubleblinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19, eClinicalMedicine
Nickols, Dematt, Effect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19: The HITCH Randomized Clinical Trial, JAMA Netw Open
Nielsen, Nørgaard, Lanzieri, Vestergaard, Moelbak, Sexdifferences in COVID-19 associated excess mortality is not exceptional for the COVID-19 pandemic, Scientific Reports
Page, Mckenzie, Bossuyt, The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, BMJ
Peckham, De Gruijter, Raine, Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission, Nature Communications
Pharma, Veru Announces Oral Late-Breaking Presentation of Phase 2
Randomized, Placebo-Controlled, Two-Arm, Parallel Clinical Trial of Proxalutamide for Hospitalized COVID-19 Patients: A Multiregional, Joint Analysis of the Proxa-Rescue AndroCoV Trial, Cureus
Seth, Sharma, Mishra, Solanki, Singh et al., Role of Short-Term Estradiol Supplementation in Symptomatic Postmenopausal COVID-19 Females: A Randomized Controlled Trial, J Midlife Health
Sterne, Savović, Page, RoB 2: a revised tool for assessing risk of bias in randomised trials, BMJ
Welén, Rosendal, Gisslén, A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data, Eur Urol
Zarehoseinzade, Allami, Ahmadi, Bijani, Mohammadi, Finasteride in hospitalized adult males with COVID-19: A risk factor for severity of the disease or an adjunct treatment: A randomized controlled clinical trial, Med J Islam Repub Iran
Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop