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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ SHOKS-COVID score 11% Improvement Relative Risk PCR+ on day 10 or hospita.. 39% Hospitalization time 8% Viral clearance 87% Spironolactone  Mareev et al.  LATE TREATMENT  RCT Is late treatment with spironolactone + bromhexine beneficial for COVID-19? RCT 66 patients in Russia Improved recovery (p=0.47) and viral clearance (p=0.077), not sig. c19early.org Mareev et al., Кардиология, December 2020 Favors spironolactone Favors control

Results of Open-Label non-Randomized Comparative Clinical Trial: “BromhexIne and Spironolactone for CoronаvirUs Infection requiring hospiTalization (BISCUIT)

Mareev et al., Кардиология, doi:10.18087/cardio.2020.11.n1440, NCT04424134
Dec 2020  
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32nd treatment shown to reduce risk in February 2022
 
*, now known with p = 0.00046 from 12 studies.
Lower risk for mortality, progression, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Prospective 103 PCR+ patients in Russia, 33 treated with bromexhine+spironolactone, showing lower PCR+ at day 10 or hospitalization >10 days with treatment. Bromhexine 8mg 4 times daily, spironolactone 25-50 mg/day for 10 days.
Study covers bromhexine and spironolactone.
relative SHOKS-COVID score, 11.3% better, RR 0.89, p = 0.47, treatment mean 2.12 (±1.39) n=33, control mean 2.39 (±1.59) n=33.
risk of PCR+ on day 10 or hospitalization >10 days, 38.8% lower, RR 0.61, p = 0.02, treatment 14 of 24 (58.3%), control 20 of 21 (95.2%), NNT 2.7, odds ratio converted to relative risk.
hospitalization time, 8.2% lower, relative time 0.92, p = 0.35, treatment 33, control 33.
risk of no viral clearance, 87.4% lower, RR 0.13, p = 0.08, treatment 0 of 17 (0.0%), control 3 of 13 (23.1%), NNT 4.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 10.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mareev et al., 3 Dec 2020, Randomized Controlled Trial, Russia, peer-reviewed, 20 authors, this trial uses multiple treatments in the treatment arm (combined with bromhexine) - results of individual treatments may vary, trial NCT04424134 (history).
This PaperSpironolactoneAll
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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