Efficacy of Ulinastatin in the Treatment of COVID-19: A Retrospective Study
Peng Liu, Qi Wu, Mengjie Li
International Journal of General Medicine, doi:10.2147/ijgm.s486434
Purpose: This retrospective study aimed to evaluate the efficacy of ulinastatin in the treatment of COVID-19 patients compared to conventional therapy. Patients and Methods: A total of 437 COVID-19 patients admitted to the Respiratory Oncology Department of our hospital between December 31, 2022, and July 8, 2023, were included in the study. Patients were classified into the observation group (n=62) receiving ulinastatin in addition to standard treatment and the control group (n=347) receiving standard treatment only. Clinical information, laboratory results, and treatment outcomes were collected and analyzed. Results: The observation group showed an improvement in lymphocyte count compared to the control group. The clinical improvement rate in patients receiving ulinastatin for 7 days or longer was 92.1%, significantly higher than that of patients treated for less than 7 days (62.5%) and those receiving standard treatment (71.0%). No significant difference in total length of hospitalization was observed between the two groups, and no related adverse events occurred in either group. Conclusion: Ulinastatin treatment improves lymphocyte counts in severe COVID-19 patients, and the clinical improvement rate is significantly higher with treatment duration of 7 days or longer. Larger-scale randomized controlled trials are warranted to further explore the role of ulinastatin in the management of COVID-19.
International Journal of General Medicine
Dovepress
DovePress International Journal of General Medicine 2024:17
References
Chen, Hu, Liu, Safety and tolerability of high-dose ulinastatin after 2-hour intravenous infusion in adult healthy Chinese volunteers: a randomized, double-blind, placebo-controlled, ascending-dose study, PLoS One,
doi:10.1371/journal.pone.0177425Chen, Wu, Guo, Clinical and immunological features of severe and moderate coronavirus disease 2019, J Clin Invest,
doi:10.1172/JCI137244Commission, Nao, Guideline on diagnosis and treatment of novel coronavirus pneumonia (Trial Version 10), Infectious Dis Inf
Drozdzal, Rosik, Lechowicz, An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment, Drug Resist Updat,
doi:10.1016/j.drup.2021.100794Karnad, Bhadade, Verma, Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study, Intensive Care Med,
doi:10.1007/s00134-014-3278-8Lagoo, Mc, Kartha, Kutappa, Role of Ulinastatin, a trypsin inhibitor, in severe acute pancreatitis in critical care setting: a retrospective analysis, J Crit Care,
doi:10.1016/j.jcrc.2018.01.021Liu, Li, Liu, Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients, EBioMedicine,
doi:10.1016/j.ebiom.2020.102763Mehta, Dixit, Zirpe, Ansari, Cytokine Storm in Novel Coronavirus Disease (COVID-19): expert Management Considerations, Indian J Crit Care Med,
doi:10.5005/jp-journals-10071-23415Mehta, Zirpe, Dixit, Ulinastatin Add-on to Standard of Care in Critically Ill COVID-19 Patients: a Multicenter, Retrospective Study, J Assoc Physicians India,
doi:10.5005/japi-11001-0181Moorthy, Gaikwad, Krishna, SARS-CoV-2, Uncontrolled Diabetes and Corticosteroids-An Unholy Trinity in Invasive Fungal Infections of the Maxillofacial Region? A Retrospective, Multi-centric Analysis, J Maxillofac Oral Surg,
doi:10.1007/s12663-021-01532-1Qiao, Guo, Huang, Zhang, Li et al., Expression of Angiopoietin-2 in Lung Tissue of Juvenile SD Rats with Lipopolysaccharide-Induced Acute Lung Injury and the Role of Ulinastatin, Arch Immunol Ther Exp (Warsz),
doi:10.1007/s00005-023-00688-7Qs, Lx, Clinical study of UTI combined with non-invasive ventilation in the treatment of acute respiratory distress syndrome, Chin J Clin Pharmacol Res
Singh, Singh, Joshi, Misra, Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2021.05.019Tali, Leblanc, Sadiq, Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/ COVID-19 Detection, Clin Microbiol Rev,
doi:10.1128/CMR.00228-20Wang, Liu, Tang, Improvement of Sepsis Prognosis by Ulinastatin: a Systematic Review and Meta-Analysis of Randomized Controlled Trials, Front Pharmacol,
doi:10.3389/fphar.2019.01370Xu, Yan, Chen, Ulinastatin is effective in reducing mortality for critically ill patients with sepsis: a causal mediation analysis, Sci Rep,
doi:10.1038/s41598-018-32533-9Zhang, Zhu, Jiao, Liu, Liu et al., Ulinastatin treatment for acute respiratory distress syndrome in China: a meta-analysis of randomized controlled trials, BMC Pulm Med,
doi:10.1186/s12890-019-0968-6Zx, The impact of Ulinastatin injection in patients′ plasma levels of CRP, PCT and lactate in ARDS patients with severe sepsis, J Pract Med
DOI record:
{
"DOI": "10.2147/ijgm.s486434",
"ISSN": [
"1178-7074"
],
"URL": "http://dx.doi.org/10.2147/ijgm.s486434",
"author": [
{
"affiliation": [],
"family": "Liu",
"given": "Peng",
"sequence": "first"
},
{
"affiliation": [],
"family": "Wu",
"given": "Qi",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Li",
"given": "Mengjie",
"sequence": "additional"
}
],
"container-title": "International Journal of General Medicine",
"container-title-short": "IJGM",
"content-domain": {
"crossmark-restriction": false,
"domain": []
},
"created": {
"date-parts": [
[
2024,
12,
23
]
],
"date-time": "2024-12-23T12:05:12Z",
"timestamp": 1734955512000
},
"deposited": {
"date-parts": [
[
2024,
12,
23
]
],
"date-time": "2024-12-23T12:05:16Z",
"timestamp": 1734955516000
},
"indexed": {
"date-parts": [
[
2024,
12,
23
]
],
"date-time": "2024-12-23T12:40:10Z",
"timestamp": 1734957610563,
"version": "3.32.0"
},
"is-referenced-by-count": 0,
"issued": {
"date-parts": [
[
2024,
12
]
]
},
"language": "en",
"license": [
{
"URL": "https://creativecommons.org/licenses/by-nc/3.0/",
"content-version": "unspecified",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2024,
12,
1
]
],
"date-time": "2024-12-01T00:00:00Z",
"timestamp": 1733011200000
}
}
],
"link": [
{
"URL": "https://www.dovepress.com/article/download/98679",
"content-type": "application/pdf",
"content-version": "vor",
"intended-application": "text-mining"
},
{
"URL": "https://www.dovepress.com/article/download/98679",
"content-type": "application/pdf",
"content-version": "vor",
"intended-application": "similarity-checking"
}
],
"member": "301",
"original-title": [],
"page": "6421-6430",
"prefix": "10.2147",
"published": {
"date-parts": [
[
2024,
12
]
]
},
"published-online": {
"date-parts": [
[
2024,
12
]
]
},
"publisher": "Informa UK Limited",
"reference": [
{
"key": "ref1",
"unstructured": "WHO Coronavirus (COVID-19) Dashboard [Internet]. Available from: https://covid19.who.int. Accessed December 9, 2024"
},
{
"DOI": "10.1016/j.cell.2021.01.007",
"author": "Sette",
"doi-asserted-by": "publisher",
"first-page": "861",
"journal-title": "Cell",
"key": "ref2",
"volume": "184",
"year": "2021"
},
{
"DOI": "10.1038/s41563-020-00906-z",
"author": "Kevadiya",
"doi-asserted-by": "publisher",
"first-page": "593",
"journal-title": "Nat Mater",
"key": "ref3",
"volume": "20",
"year": "2021"
},
{
"DOI": "10.1128/CMR.00228-20",
"author": "Safiabadi Tali",
"doi-asserted-by": "publisher",
"journal-title": "Clin Microbiol Rev",
"key": "ref4",
"volume": "34",
"year": "2021"
},
{
"DOI": "10.3389/fimmu.2023.1125246",
"author": "Yuan",
"doi-asserted-by": "publisher",
"first-page": "1125246",
"journal-title": "Front Immunol",
"key": "ref5",
"volume": "14",
"year": "2023"
},
{
"DOI": "10.1016/j.drup.2021.100794",
"author": "Drozdzal",
"doi-asserted-by": "publisher",
"first-page": "100794",
"journal-title": "Drug Resist Updat",
"key": "ref6",
"volume": "59",
"year": "2021"
},
{
"DOI": "10.1172/JCI137244",
"author": "Chen",
"doi-asserted-by": "publisher",
"first-page": "2620",
"journal-title": "J Clin Invest",
"key": "ref7",
"volume": "130",
"year": "2020"
},
{
"DOI": "10.1186/s12890-019-0968-6",
"author": "Zhang",
"doi-asserted-by": "publisher",
"first-page": "196",
"journal-title": "BMC Pulm Med",
"key": "ref8",
"volume": "19",
"year": "2019"
},
{
"DOI": "10.3389/fphar.2019.01370",
"author": "Wang",
"doi-asserted-by": "publisher",
"first-page": "1370",
"journal-title": "Front Pharmacol",
"key": "ref9",
"volume": "10",
"year": "2019"
},
{
"DOI": "10.1007/s00005-023-00688-7",
"author": "Qiao",
"doi-asserted-by": "publisher",
"first-page": "23",
"journal-title": "Arch Immunol Ther Exp (Warsz)",
"key": "ref10",
"volume": "71",
"year": "2023"
},
{
"DOI": "10.1016/j.intimp.2022.108908",
"author": "Jin",
"doi-asserted-by": "publisher",
"first-page": "108908",
"journal-title": "Int Immunopharmacol",
"key": "ref11",
"volume": "108",
"year": "2022"
},
{
"DOI": "10.5005/jp-journals-10071-23415",
"author": "Mehta",
"doi-asserted-by": "publisher",
"first-page": "429",
"journal-title": "Indian J Crit Care Med",
"key": "ref12",
"volume": "24",
"year": "2020"
},
{
"DOI": "10.5005/japi-11001-0181",
"author": "Mehta",
"doi-asserted-by": "publisher",
"first-page": "11",
"journal-title": "J Assoc Physicians India",
"key": "ref13",
"volume": "71",
"year": "2023"
},
{
"DOI": "10.5005/jp-journals-10071-24156",
"author": "Jain",
"doi-asserted-by": "publisher",
"first-page": "696",
"journal-title": "Indian J Crit Care Med",
"key": "ref14",
"volume": "26",
"year": "2022"
},
{
"author": "Commission",
"first-page": "18",
"journal-title": "Infectious Dis Inf",
"key": "ref15",
"volume": "36",
"year": "2023"
},
{
"DOI": "10.3892/etm.2021.11044",
"author": "Huang",
"doi-asserted-by": "publisher",
"first-page": "121",
"journal-title": "Exp Ther Med",
"key": "ref16",
"volume": "23",
"year": "2022"
},
{
"DOI": "10.1007/s12663-021-01532-1",
"author": "Moorthy",
"doi-asserted-by": "publisher",
"first-page": "418",
"journal-title": "J Maxillofac Oral Surg",
"key": "ref17",
"volume": "20",
"year": "2021"
},
{
"DOI": "10.1016/j.dsx.2021.05.019",
"author": "Singh",
"doi-asserted-by": "publisher",
"first-page": "102146",
"journal-title": "Diabetes Metab Syndr",
"key": "ref18",
"volume": "15",
"year": "2021"
},
{
"DOI": "10.1371/journal.pone.0177425",
"author": "Chen",
"doi-asserted-by": "publisher",
"first-page": "e0177425",
"journal-title": "PLoS One",
"key": "ref19",
"volume": "12",
"year": "2017"
},
{
"DOI": "10.1038/s41598-018-32533-9",
"author": "Xu",
"doi-asserted-by": "publisher",
"first-page": "14360",
"journal-title": "Sci Rep",
"key": "ref20",
"volume": "8",
"year": "2018"
},
{
"DOI": "10.1007/s00134-014-3278-8",
"author": "Karnad",
"doi-asserted-by": "publisher",
"first-page": "830",
"journal-title": "Intensive Care Med",
"key": "ref21",
"volume": "40",
"year": "2014"
},
{
"DOI": "10.1016/j.jcrc.2018.01.021",
"author": "Lagoo",
"doi-asserted-by": "publisher",
"first-page": "27",
"journal-title": "J Crit Care",
"key": "ref22",
"volume": "45",
"year": "2018"
},
{
"DOI": "10.1016/j.ebiom.2020.102763",
"author": "Liu",
"doi-asserted-by": "publisher",
"first-page": "102763",
"journal-title": "EBioMedicine",
"key": "ref23",
"volume": "55",
"year": "2020"
},
{
"DOI": "10.11613/BM.2021.030501",
"author": "Palladino",
"doi-asserted-by": "publisher",
"first-page": "030501",
"journal-title": "Biochem Med (Zagreb)",
"key": "ref24",
"volume": "31",
"year": "2021"
},
{
"author": "QS",
"first-page": "1268",
"journal-title": "Chin J Clin Pharmacol Res",
"key": "ref25",
"volume": "32",
"year": "2016"
},
{
"author": "ZX",
"first-page": "1692",
"journal-title": "J Pract Med",
"key": "ref26",
"volume": "31",
"year": "2015"
}
],
"reference-count": 26,
"references-count": 26,
"relation": {},
"resource": {
"primary": {
"URL": "https://www.dovepress.com/efficacy-of-ulinastatin-in-the-treatment-of-covid-19-a-retrospective-s-peer-reviewed-fulltext-article-IJGM"
}
},
"score": 1,
"short-title": [],
"source": "Crossref",
"subject": [],
"subtitle": [],
"title": "Efficacy of Ulinastatin in the Treatment of COVID-19: A Retrospective Study",
"type": "journal-article",
"volume": "Volume 17"
}
