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c19early.org COVID-19 treatment researchAzvudineAzvudine (more..)
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Azvudine alleviates SARS-CoV-2-induced inflammation by targeting myeloperoxidase in NETosis

Li et al., Chinese Chemical Letters, doi:10.1016/j.cclet.2024.110238, Jul 2024
https://c19early.org/li38.html
Azvudine for COVID-19
47th treatment shown to reduce risk in July 2023, now with p = 0.0000022 from 34 studies.
Lower risk for mortality, progression, and viral clearance.
No treatment is 100% effective. Protocols combine treatments.
5,600+ studies for 131 treatments. c19early.org
In Silico, In Vitro, and rhesus macaque study showing that azvudine (FNC) alleviates SARS-CoV-2-induced inflammation by targeting myeloperoxidase (MPO) and reducing neutrophil extracellular trap (NET) formation. Authors demonstrated FNC's dual action as both an antiviral and anti-inflammatory agent in SARS-CoV-2 infected rhesus macaques, effectively reducing neutrophil infiltration and inflammatory injury. Using mass spectrometry-based proteomics, LiP-MS, CETSA, and Co-IP analyses, authors identified MPO as FNC's therapeutic target and confirmed its effects on NET formation in both rhesus macaque tissues and differentiated HL-60 cells. The findings suggest FNC could be particularly valuable for treating both acute COVID-19 and long COVID, where NETosis serves as a clinical biomarker of disease severity.
3 preclinical studies support the efficacy of azvudine for COVID-19:
Li et al., 31 Jul 2024, peer-reviewed, 6 authors.
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