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0 0.5 1 1.5 2+ Mortality 76% Improvement Relative Risk Metformin for COVID-19  Li et al.  LATE TREATMENT Is late treatment with metformin beneficial for COVID-19? Retrospective 131 patients in China Lower mortality with metformin (p=0.022) Li et al., Endocrinology, Diabetes &am.., Sep 2021 Favors metformin Favors control

Inpatient use of metformin and acarbose is associated with reduced mortality of COVID-19 patients with type 2 diabetes mellitus

Li et al., Endocrinology, Diabetes & Metabolism, doi:10.1002/edm2.301
Sep 2021  
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Retrospective 131 hospitalized COVID-19 patients with type 2 diabetes, showing lower mortality with metformin treatment and acarbose treatment.
risk of death, 75.8% lower, RR 0.24, p = 0.02, treatment 2 of 37 (5.4%), control 21 of 94 (22.3%), NNT 5.9.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Li et al., 29 Sep 2021, retrospective, China, peer-reviewed, 13 authors.
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This PaperMetforminAll
Inpatient use of metformin and acarbose is associated with reduced mortality of COVID‐19 patients with type 2 diabetes mellitus
Jinghong Li, Qi Wei, Karen C Mccowen, Wei Xiong, Jiao Liu, Wenlijun Jiang, Robert L Thomas, Mark Hepokoski, Ming He, John Y J Shyy, Atul Malhotra, Nian Xiong, Willis X Li
Endocrinology, Diabetes & Metabolism, doi:10.1002/edm2.301
This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DATA AVA I L A B I L I T Y S TAT E M E N T The data that support the findings of this study are available upon request from the lead author, J.L. O RCI D Willis X. Li R E FE R E N C E S
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Late treatment
is less effective
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