Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19
MD Thorsten M Leucker, MS William O Osburn, MS Paula Reventun, BA Kimberley Smith, PHD Brian Claggett, PHD Bridget-Anne Kirwan, PHD Sophie De Brouwer, MD Marlene S Williams, MD, JD Gary Gerstenblith, MD David N Hager, MD Michael B Streiff, MD Scott D Solomon, MD Charles J Lowenstein
JACC: Basic to Translational Science, doi:10.1016/j.jacbts.2021.09.013
Severe COVID-19 is characterized by vascular inflammation and thrombosis, including elevations of P-selectin, a marker released by activated endothelial cells that mediates vascular inflammation. We tested the effect of crizanlizumab, an antibody to P-selectin, on biomarkers of inflammation and thrombosis in patients with COVID-19 in a randomized, placebocontrolled, double-blind clinical trial. Crizanlizumab decreased soluble Pselectin levels in patients with COVID-19. Crizanlizumab increased D-dimer and decreased prothrombin fragment 1.2 in patients with COVID-19. Crizanlizumab may induce endogenous thrombolysis in the setting of COVID-19.
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R E F E R E N C E S 1. Lowenstein, Solomon, 93 Values are median (interquartile range) unless noted otherwise. Absolute levels of biomarkers of patients treated with placebo and patients treated with crizanlizumab on baseline day 1 or on day 3 or before discharge (n ¼ sample size). IL ¼ interleukin; NT-proBNP ¼ N-terminal pro-B-type natriuretic peptide; PAP ¼ plasmin-antiplasmin complex; SAA ¼ serum amyloid A; TAT ¼ thrombin-antithrombin, Circulation
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