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c19early.org COVID-19 treatment researchN-acetylcysteineN-acetylcys.. (more..)
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Effect of N-Acetylcysteine on mortality in COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials

Kow et al., Inflammopharmacology, doi:10.1007/s10787-025-01876-x, Jul 2025
https://c19early.org/kow12.html
Mortality 51% Improvement Relative Risk N-acetylcysteine  Kow et al.  META ANALYSIS c19early.org FavorsN-acetylcysteine Favorscontrol 0 0.5 1 1.5 2+
15th treatment shown to reduce risk in February 2021, now with p = 0.000028 from 24 studies, recognized in 3 countries.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine treatments.
6,000+ studies for 175 treatments. c19early.org
Meta analysis of 10 RCTs with 1,424 patients, showing significantly lower mortality with N-acetylcysteine.
2 meta analyses show significant improvement with N-acetylcysteine for mortality1,2.
Currently there are 24 N-acetylcysteine for COVID-19 studies, showing 31% lower mortality [14‑44%], 6% lower ventilation [-25‑29%], 7% lower ICU admission [-16‑26%], 11% lower hospitalization [6‑17%], and 28% fewer cases [21‑34%].
risk of death, 51.0% lower, OR 0.49, p = 0.03, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kow et al., 29 Jul 2025, peer-reviewed, 4 authors.
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