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SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding (SHIELD)

Keating et al., NCT04478019, SHIELD, NCT04478019

Jun 2022

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Chlorhexidine

46th treatment shown to reduce risk in January 2024, now with p = 0.00000000062 from 3 studies.

Lower risk for progression, cases, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 109 treatments. c19early.org

245 participant chlorhexidine + PVP-I prophylaxis RCT with results not reported over 2 years after completion.

4 chlorhexidine RCTs have results missing long after expected1-4
The trials report a total of 512 patients, with 3 trials having actual enrollment of 422, and the other estimated.

Important missing comments or errors? Let us know.

Study covers chlorhexidine and povidone-iodine.

1. Keating et al., SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding (SHIELD), NCT04478019, clinicaltrials.gov/study/NCT04478019.clinicaltrials.gov.

2. Xie et al., Oral Rinse to Reduced Expelled Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) During COVID-19 Infection, NCT04931004, clinicaltrials.gov/study/NCT04931004.clinicaltrials.gov.

3. Mira et al., Evaluation of the Efficacy of Mouth Rinses With Commercial Mouthwashes to Decrease Viral Load in Saliva in COVID-19 Patients, NCT05543603, clinicaltrials.gov/study/NCT05543603.clinicaltrials.gov.

4. Jacox et al., Mouth Rinses for Inactivation of COVID-19 (MOR), NCT04584684, clinicaltrials.gov/study/NCT04584684.clinicaltrials.gov.

Keating et al., 30 Jun 2022, Randomized Controlled Trial, USA, this trial uses multiple treatments in the treatment arm (combined with PVP-I) - results of individual treatments may vary, trial NCT04478019 (history) (SHIELD). Contact: ns2@medicine.wisc.edu, dshirley@medicine.wisc.edu, jakeating@medicine.wisc.edu, SHIELD@medicine.wisc.edu, klhaight@medicine.wisc.edu, jperzynski@medicine.wisc.edu, mzimbric@medicine.wisc.edu.

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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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