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Melatonin as adjunctive therapy in patients admitted to the Covid-19

Karimpour-razkenari et al., Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103492
Mar 2022  
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Mortality 39% Improvement Relative Risk Ventilation time 43% ICU time 2% Melatonin  Karimpour-razkenari et al.  ICU PATIENTS Is very late treatment with melatonin beneficial for COVID-19? Retrospective 31 patients in Iran (March - May 2020) Lower mortality (p=0.37) and shorter ventilation (p=0.13), not sig. c19early.org Karimpour-razkenari et al., Annals of .., Mar 2022 Favorsmelatonin Favorscontrol 0 0.5 1 1.5 2+
Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments. c19early.org
Retrospective 31 ICU patients, 12 treated with melatonin, showing lower mortality with treatment, without statistical significance. Melatonin 15mg daily.
Although the 39% lower mortality is not statistically significant, it is consistent with the significant 48% lower mortality [27‑63%] from meta analysis of the 9 mortality results to date.
risk of death, 39.0% lower, HR 0.61, p = 0.37, treatment 5 of 12 (41.7%), control 13 of 19 (68.4%), NNT 3.7, Kaplan–Meier.
ventilation time, 42.9% lower, relative time 0.57, p = 0.13, treatment 12, control 19.
ICU time, 1.9% lower, relative time 0.98, p = 0.85, treatment 12, control 19.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karimpour-razkenari et al., 10 Mar 2022, retrospective, Iran, peer-reviewed, 6 authors, study period 13 March, 2020 - 30 May, 2020.
This PaperMelatoninAll
Melatonin as adjunctive therapy in patients admitted to the Covid-19
Elahe Karimpour-Razkenari, Fahimeh Naderi-Behdani, Ali Salahshoor, Fatemeh Heydari, Abbas Alipour, Afshin Gholipour Baradari
Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103492
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Please state any conflicts of interest All authors must disclose any financial and personal relationships with other people or organisations that could inappropriately influence (bias) their work. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding. The authors deny any conflict of interest in any terms or by any means during the study. Please state any sources of funding for your research All sources of funding should be declared as an acknowledgement at the end of the text. Authors should declare the role of study sponsors, if any, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. If the study sponsors had no such involvement, the authors should so state. No funding was secured for this study Ethical Approval Research studies involving patients require ethical approval. Please state whether approval has been given, name the relevant ethics committee and the state the reference number for their judgement. All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Consent Studies on patients or volunteers require ethics..
References
Aghsaeifard, Alizadeh, The Role of Angiotensin-Converting Enzyme in Immunity: Shedding Light on Experimental Findings, Endocr Metab Immune Disord Drug Targets
Alizadeh, Aghsaeifard, Does COVID19 activates previous chronic pain? A case series, Ann Med Surg (Lond)
Alizadeh, Keyhanian, Ghaderkhani, Dashti-Khavidaki, Shoormasti et al., A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement, Iranian Journal of Allergy, Asthma and Immunology
Andersen, Gögenur, Rosenberg, Reiter, The safety of melatonin in humans, Clinical drug investigation
Biancatelli, Berrill, Mohammed, Marik, Melatonin for the treatment of sepsis: the scientific rationale, Journal of thoracic disease
Carrillo-Vico, Lardone, Álvarez-Sánchez, Rodríguez-Rodríguez, Guerrero, Melatonin: buffering the immune system, International journal of molecular sciences
Castillo, Quizon, Juco, Roman, Leon et al., Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): a case series, Melatonin research
Channappanavar, Perlman, Editors, Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology, Seminars in immunopathology
Chen, Pathogenicity and transmissibility of 2019-nCoV-a quick overview and comparison with other emerging viruses, Microbes
Cui, Yu, Luo, Dai, Han et al., Intracellular signaling pathways involved in cell growth inhibition of human umbilical vein endothelial cells by melatonin, Journal of pineal research
Davoodian, Sharifimood, Salarbashi, Elyasi, Baniasad et al., The effect of melatonin as an adjuvant therapy on COVID-19: A Randomized Clinical Trial
Farnoosh, Akbariqomi, Badri, Bagheri, Izadi et al., Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial: Adjuvant treatment of melatonin in COVID-19 patients, Archives of Medical Research
Hardeland, Melatonin and inflammation-Story of a double-edged blade, Journal of pineal research
Javid, Hosseini, Gholinezhad, Moradi, Haghighi-Zadeh et al., Antioxidant and anti-inflammatory properties of melatonin in patients with type 2 diabetes mellitus with periodontal disease under non-surgical periodontal therapy: a double-blind, placebo-controlled trial. Diabetes, metabolic syndrome and obesity: targets and therapy
Jehi, Ji, Milinovich, Erzurum, Rubin et al., Individualizing risk prediction for positive coronavirus disease 2019 testing: results from 11,672 patients, Chest
Jimeno, Ventura, Castellano, García-Adasme, Miranda et al., Prognostic implications of neutrophil-lymphocyte ratio in COVID-19, European Journal of Clinical Investigation
Khwaja, KDIGO clinical practice guidelines for acute kidney injury, Nephron Clinical Practice
Lescot, Karvellas, Beaussier, Magder, Riou, Acquired liver injury in the intensive care unit, The Journal of the American Society of Anesthesiologists
Li, Liu, Mao, Xiao, Wang et al., Predictive values of neutrophil-tolymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis, Critical Care
Liang, Liang, Ou, Chen, Chen et al., Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19, JAMA internal medicine
Liu, Du, Chen, Jin, Peng et al., Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19, Journal of Infection
López-Escobar, Madurga, Castellano, De Aguiar, Velázquez et al., Hemogram as marker of in-hospital mortality in COVID-19, Journal of Investigative Medicine
López-Escobar, Madurga, Castellano, Velázquez, Del Villar et al., Risk score for predicting in-hospital mortality in COVID-19 (rim score), Diagnostics
Mathew, Agha, Albrecht, Goel, Mukherjee et al., Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery, Annals of Medicine and Surgery
Moniruzzaman, Ghosal, Das, Chakraborty, Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk/Akt/NFkB pathway, Biological Research
Mortezaee, Potes, Mirtavoos-Mahyari, Motevaseli, Shabeeb et al., Boosting immune system against cancer by melatonin: A mechanistic viewpoint, Life sciences
Pasricha, Colman, Centeno-Tablante, Garcia-Casal, Peña-Rosas, None
Ramlall, Zucker, Tatonetti, Melatonin is significantly associated with survival of intubated COVID-19 patients
Reiter, Mayo, Tan, Sainz, Jimenez et al., Melatonin as an antioxidant: under promises but over delivers, Journal of pineal research
Ren, Liu, Chen, Yin, Wang et al., Melatonin signaling in T cells: Functions and applications, Journal of pineal research
Reynolds, Dubocovich, Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID-19, Journal of Pineal Research
Shohrati, Mohammadi, Najafi, Sharifzadeh, Sharifnia et al., Evaluation of the Effects of Melatonin Supplementation on Coagulation in Patients with Haemorrhagic Stroke; A Randomized, Double-Blind, Controlled Trial, Frontiers in Emergency Medicine
Srinivasan, Mohamed, Kato, Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent patents on endocrine, metabolic & immune drug discovery
Sung, Bae, Lee, Kim, Kim, The melatonin signaling pathway in a long-term memory in vitro study, Molecules
Yang, Cao, Du, Wu, Zhuang et al., Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis, Annals of translational medicine
Yang, Liu, Tao, Li, The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients, International immunopharmacology
Zhang, Wang, Ni, Di, Ma et al., COVID-19: Melatonin as a potential adjuvant treatment, Life sciences
Zhang, Yan, Tian, Li, Wang et al., Synthesis of a new water-soluble melatonin derivative with low toxicity and a strong effect on sleep aid, ACS omega
Zhou, Hou, Shen, Mehra, Kallianpur et al., A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19, PLoS biology
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Pineal Res.'}, { 'key': '10.1016/j.amsu.2022.103492_bib11', 'doi-asserted-by': 'crossref', 'DOI': '10.1186/s40659-018-0168-5', 'article-title': 'Melatonin ameliorates H2O2-induced oxidative stress through modulation ' 'of Erk/Akt/NFkB pathway', 'volume': '51', 'author': 'Moniruzzaman', 'year': '2018', 'journal-title': 'Biol. Res.'}, { 'issue': '3', 'key': '10.1016/j.amsu.2022.103492_bib12', 'first-page': 'e32', 'article-title': 'Evaluation of the effects of melatonin supplementation on coagulation ' 'in patients with haemorrhagic stroke; A randomized, double-blind, ' 'controlled trial', 'volume': '5', 'author': 'Shohrati', 'year': '2021', 'journal-title': 'Front. Emerg. Med.'}, { 'issue': '3', 'key': '10.1016/j.amsu.2022.103492_bib13', 'doi-asserted-by': 'crossref', 'first-page': '169', 'DOI': '10.1007/s40261-015-0368-5', 'article-title': 'The safety of melatonin in humans', 'volume': '36', 'author': 'Andersen', 'year': '2016', 'journal-title': 'Clin. Drug Invest.'}, { 'issue': '12', 'key': '10.1016/j.amsu.2022.103492_bib14', 'doi-asserted-by': 'crossref', 'first-page': '6494', 'DOI': '10.1021/acsomega.9b04120', 'article-title': 'Synthesis of a new water-soluble melatonin derivative with low toxicity ' 'and a strong effect on sleep aid', 'volume': '5', 'author': 'Zhang', 'year': '2020', 'journal-title': 'ACS Omega'}, { 'issue': '4', 'key': '10.1016/j.amsu.2022.103492_bib15', 'first-page': 'c179', 'article-title': 'KDIGO clinical practice guidelines for acute kidney injury', 'volume': '120', 'author': 'Khwaja', 'year': '2012', 'journal-title': 'Nephron Clin. Pract.'}, { 'issue': '4', 'key': '10.1016/j.amsu.2022.103492_bib16', 'first-page': '898', 'article-title': 'Acquired liver injury in the intensive care unit', 'volume': '117', 'author': 'Lescot', 'year': '2012', 'journal-title': 'J. Am. Soc. Anesthesiologists'}, { 'issue': '2', 'key': '10.1016/j.amsu.2022.103492_bib17', 'doi-asserted-by': 'crossref', 'first-page': 'e60', 'DOI': '10.1016/S2352-3026(18)30004-8', 'article-title': 'Revisiting WHO haemoglobin thresholds to define anaemia in clinical ' 'medicine and public health', 'volume': '5', 'author': 'Pasricha', 'year': '2018', 'journal-title': 'Lancet Haematol.'}, { 'key': '10.1016/j.amsu.2022.103492_bib18', 'doi-asserted-by': 'crossref', 'first-page': '103026', 'DOI': '10.1016/j.amsu.2021.103026', 'article-title': 'STROCSS 2021: strengthening the reporting of cohort, cross-sectional ' 'and case-control studies in surgery', 'volume': '72', 'author': 'Mathew', 'year': '2021', 'journal-title': 'Ann. Med. Surg.'}, { 'key': '10.1016/j.amsu.2022.103492_bib19', 'doi-asserted-by': 'crossref', 'first-page': '117583', 'DOI': '10.1016/j.lfs.2020.117583', 'article-title': 'COVID-19: melatonin as a potential adjuvant treatment', 'volume': '250', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Life Sci.'}, { 'issue': '4', 'key': '10.1016/j.amsu.2022.103492_bib20', 'doi-asserted-by': 'crossref', 'first-page': '8638', 'DOI': '10.3390/ijms14048638', 'article-title': 'Melatonin: buffering the immune system', 'volume': '14', 'author': 'Carrillo-Vico', 'year': '2013', 'journal-title': 'Int. J. Mol. Sci.'}, { 'issue': '1', 'key': '10.1016/j.amsu.2022.103492_bib21', 'doi-asserted-by': 'crossref', 'first-page': '30', 'DOI': '10.2174/187221412799015317', 'article-title': 'Melatonin in bacterial and viral infections with focus on sepsis: a ' 'review', 'volume': '6', 'author': 'Srinivasan', 'year': '2012', 'journal-title': 'Recent Pat. Endocr. Metab. Immune Drug Discov.'}, { 'issue': '1', 'key': '10.1016/j.amsu.2022.103492_bib22', 'doi-asserted-by': 'crossref', 'first-page': '6', 'DOI': '10.2174/1871530321666210212144511', 'article-title': 'The role of angiotensin-converting enzyme in immunity: shedding light ' 'on experimental findings', 'volume': '22', 'author': 'Aghsaeifard', 'year': '2022', 'journal-title': 'Endocr. Metab. Immune Disord. - Drug Targets'}, { 'key': '10.1016/j.amsu.2022.103492_bib23', 'doi-asserted-by': 'crossref', 'first-page': '169', 'DOI': '10.1016/j.amsu.2020.12.045', 'article-title': 'Does COVID19 activates previous chronic pain? A case series', 'volume': '61', 'author': 'Alizadeh', 'year': '2021', 'journal-title': 'Ann. Med. Surg. (Lond).'}, { 'issue': 'Suppl 1', 'key': '10.1016/j.amsu.2022.103492_bib24', 'doi-asserted-by': 'crossref', 'first-page': 'S54', 'DOI': '10.21037/jtd.2019.12.85', 'article-title': 'Melatonin for the treatment of sepsis: the scientific rationale', 'volume': '12', 'author': 'Biancatelli', 'year': '2020', 'journal-title': 'J. Thorac. Dis.'}, { 'issue': '11', 'key': '10.1016/j.amsu.2022.103492_bib25', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pbio.3000970', 'article-title': 'A network medicine approach to investigation and population-based ' 'validation of disease manifestations and drug repurposing for COVID-19', 'volume': '18', 'author': 'Zhou', 'year': '2020', 'journal-title': 'PLoS Biol.'}, { 'issue': '4', 'key': '10.1016/j.amsu.2022.103492_bib26', 'doi-asserted-by': 'crossref', 'first-page': '1364', 'DOI': '10.1016/j.chest.2020.05.580', 'article-title': 'Individualizing risk prediction for positive coronavirus disease 2019 ' 'testing: results from 11,672 patients', 'volume': '158', 'author': 'Jehi', 'year': '2020', 'journal-title': 'Chest'}, { 'key': '10.1016/j.amsu.2022.103492_bib27', 'first-page': '1', 'article-title': 'A pilot study on controlling coronavirus disease 2019 (COVID-19) ' 'inflammation using melatonin supplement', 'author': 'Alizadeh', 'year': '2021', 'journal-title': 'Iran. J. Allergy, Asthma Immunol.'}, { 'key': '10.1016/j.amsu.2022.103492_bib28', 'series-title': 'Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in ' 'Hospitalized Patients with COVID-19: A Randomized, Double-Blind Clinical ' 'Trial: Adjuvant Treatment of Melatonin in COVID-19 Patients', 'author': 'Farnoosh', 'year': '2021'}, { 'key': '10.1016/j.amsu.2022.103492_bib29', 'unstructured': 'Davoodian N, Sharifimood F, Salarbashi D, Elyasi S, Baniasad A, ' 'Bejestani FS. The effect of melatonin as an adjuvant therapy on ' 'COVID-19: a Randomized Clinical Trial. Available at: SSRN 3878090.'}, { 'key': '10.1016/j.amsu.2022.103492_bib30', 'doi-asserted-by': 'crossref', 'article-title': 'Melatonin multifaceted pharmacological actions on melatonin receptors ' 'converging to abrogate COVID‐19', 'author': 'Reynolds', 'year': '2021', 'journal-title': 'J. Pineal Res.', 'DOI': '10.1111/jpi.12732'}, { 'issue': '3', 'key': '10.1016/j.amsu.2022.103492_bib31', 'doi-asserted-by': 'crossref', 'first-page': '297', 'DOI': '10.32794/mr11250063', 'article-title': 'Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia ' 'patients requiring hospitalization (MAC-19 PRO): a case series', 'volume': '3', 'author': 'Castillo', 'year': '2020', 'journal-title': 'Melatonin Res.'}, { 'key': '10.1016/j.amsu.2022.103492_bib32', 'article-title': 'Melatonin is significantly associated with survival of intubated ' 'COVID-19 patients', 'author': 'Ramlall', 'year': '2020', 'journal-title': 'medRxiv'}, { 'key': '10.1016/j.amsu.2022.103492_bib33', 'doi-asserted-by': 'crossref', 'first-page': '106504', 'DOI': '10.1016/j.intimp.2020.106504', 'article-title': 'The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 ' 'patients', 'volume': '84', 'author': 'Yang', 'year': '2020', 'journal-title': 'Int. Immunopharm.'}, { 'issue': '1', 'key': '10.1016/j.amsu.2022.103492_bib34', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1186/s13054-020-03374-8', 'article-title': 'Predictive values of neutrophil-to-lymphocyte ratio on disease severity ' 'and mortality in COVID-19 patients: a systematic review and ' 'meta-analysis', 'volume': '24', 'author': 'Li', 'year': '2020', 'journal-title': 'Crit. Care'}, { 'issue': '5', 'key': '10.1016/j.amsu.2022.103492_bib35', 'doi-asserted-by': 'crossref', 'first-page': '962', 'DOI': '10.1136/jim-2021-001810', 'article-title': 'Hemogram as marker of in-hospital mortality in COVID-19', 'volume': '69', 'author': 'López-Escobar', 'year': '2021', 'journal-title': 'J. Invest. Med.'}, { 'issue': '4', 'key': '10.1016/j.amsu.2022.103492_bib36', 'doi-asserted-by': 'crossref', 'first-page': '596', 'DOI': '10.3390/diagnostics11040596', 'article-title': 'Risk score for predicting in-hospital mortality in COVID-19 (rim score)', 'volume': '11', 'author': 'López-Escobar', 'year': '2021', 'journal-title': 'Diagnostics'}, { 'issue': '8', 'key': '10.1016/j.amsu.2022.103492_bib37', 'doi-asserted-by': 'crossref', 'first-page': '1081', 'DOI': '10.1001/jamainternmed.2020.2033', 'article-title': 'Development and validation of a clinical risk score to predict the ' 'occurrence of critical illness in hospitalized patients with COVID-19', 'volume': '180', 'author': 'Liang', 'year': '2020', 'journal-title': 'JAMA Intern. 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Late treatment
is less effective
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