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0 0.5 1 1.5 2+ Mortality 39% Improvement Relative Risk Ventilation time 43% ICU time 2% Melatonin  Karimpour-razkenari et al.  ICU PATIENTS Is very late treatment with melatonin beneficial for COVID-19? Retrospective 31 patients in Iran (March - May 2020) Lower mortality (p=0.37) and shorter ventilation (p=0.13), not sig. Karimpour-razkenari et al., Annals of .., Mar 2022 Favors melatonin Favors control

Melatonin as adjunctive therapy in patients admitted to the Covid-19

Karimpour-razkenari et al., Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103492
Mar 2022  
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Retrospective 31 ICU patients, 12 treated with melatonin, showing lower mortality with treatment, without statistical significance. Melatonin 15mg daily.
Although the 39% lower mortality is not statistically significant, it is consistent with the significant 48% lower mortality [27‑63%] from meta analysis of the 9 mortality results to date.
risk of death, 39.0% lower, HR 0.61, p = 0.37, treatment 5 of 12 (41.7%), control 13 of 19 (68.4%), NNT 3.7, Kaplan–Meier.
ventilation time, 42.9% lower, relative time 0.57, p = 0.13, treatment 12, control 19.
ICU time, 1.9% lower, relative time 0.98, p = 0.85, treatment 12, control 19.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Karimpour-razkenari et al., 10 Mar 2022, retrospective, Iran, peer-reviewed, 6 authors, study period 13 March, 2020 - 30 May, 2020.
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Melatonin as adjunctive therapy in patients admitted to the Covid-19
Elahe Karimpour-Razkenari, Fahimeh Naderi-Behdani, Ali Salahshoor, Fatemeh Heydari, Abbas Alipour, Afshin Gholipour Baradari
Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103492
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Please state any conflicts of interest All authors must disclose any financial and personal relationships with other people or organisations that could inappropriately influence (bias) their work. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding. The authors deny any conflict of interest in any terms or by any means during the study. Please state any sources of funding for your research All sources of funding should be declared as an acknowledgement at the end of the text. Authors should declare the role of study sponsors, if any, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. If the study sponsors had no such involvement, the authors should so state. No funding was secured for this study Ethical Approval Research studies involving patients require ethical approval. Please state whether approval has been given, name the relevant ethics committee and the state the reference number for their judgement. All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Consent Studies on patients or volunteers require ethics..
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Late treatment
is less effective
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