Melatonin as adjunctive therapy in patients admitted to the Covid-19
Elahe Karimpour-Razkenari, Fahimeh Naderi-Behdani, Ali Salahshoor, Fatemeh Heydari, Abbas Alipour, Afshin Gholipour Baradari
Annals of Medicine and Surgery, doi:10.1016/j.amsu.2022.103492
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References
Aghsaeifard, Alizadeh, The Role of Angiotensin-Converting Enzyme in Immunity: Shedding Light on Experimental Findings, Endocr Metab Immune Disord Drug Targets
Alizadeh, Aghsaeifard, Does COVID19 activates previous chronic pain? A case series, Ann Med Surg (Lond)
Alizadeh, Keyhanian, Ghaderkhani, Dashti-Khavidaki, Shoormasti et al., A Pilot Study on Controlling Coronavirus Disease 2019 (COVID-19) Inflammation Using Melatonin Supplement, Iranian Journal of Allergy, Asthma and Immunology
Andersen, Gögenur, Rosenberg, Reiter, The safety of melatonin in humans, Clinical drug investigation
Biancatelli, Berrill, Mohammed, Marik, Melatonin for the treatment of sepsis: the scientific rationale, Journal of thoracic disease
Carrillo-Vico, Lardone, Álvarez-Sánchez, Rodríguez-Rodríguez, Guerrero, Melatonin: buffering the immune system, International journal of molecular sciences
Castillo, Quizon, Juco, Roman, Leon et al., Melatonin as adjuvant treatment for coronavirus disease 2019 pneumonia patients requiring hospitalization (MAC-19 PRO): a case series, Melatonin research
Channappanavar, Perlman, Editors, Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology, Seminars in immunopathology
Chen, Pathogenicity and transmissibility of 2019-nCoV-a quick overview and comparison with other emerging viruses, Microbes
Cui, Yu, Luo, Dai, Han et al., Intracellular signaling pathways involved in cell growth inhibition of human umbilical vein endothelial cells by melatonin, Journal of pineal research
Davoodian, Sharifimood, Salarbashi, Elyasi, Baniasad et al., The effect of melatonin as an adjuvant therapy on COVID-19: A Randomized Clinical Trial
Farnoosh, Akbariqomi, Badri, Bagheri, Izadi et al., Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial: Adjuvant treatment of melatonin in COVID-19 patients, Archives of Medical Research
Hardeland, Melatonin and inflammation-Story of a double-edged blade, Journal of pineal research
Javid, Hosseini, Gholinezhad, Moradi, Haghighi-Zadeh et al., Antioxidant and anti-inflammatory properties of melatonin in patients with type 2 diabetes mellitus with periodontal disease under non-surgical periodontal therapy: a double-blind, placebo-controlled trial. Diabetes, metabolic syndrome and obesity: targets and therapy
Jehi, Ji, Milinovich, Erzurum, Rubin et al., Individualizing risk prediction for positive coronavirus disease 2019 testing: results from 11,672 patients, Chest
Jimeno, Ventura, Castellano, García-Adasme, Miranda et al., Prognostic implications of neutrophil-lymphocyte ratio in COVID-19, European Journal of Clinical Investigation
Khwaja, KDIGO clinical practice guidelines for acute kidney injury, Nephron Clinical Practice
Lescot, Karvellas, Beaussier, Magder, Riou, Acquired liver injury in the intensive care unit, The Journal of the American Society of Anesthesiologists
Li, Liu, Mao, Xiao, Wang et al., Predictive values of neutrophil-tolymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis, Critical Care
Liang, Liang, Ou, Chen, Chen et al., Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19, JAMA internal medicine
Liu, Du, Chen, Jin, Peng et al., Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19, Journal of Infection
López-Escobar, Madurga, Castellano, De Aguiar, Velázquez et al., Hemogram as marker of in-hospital mortality in COVID-19, Journal of Investigative Medicine
López-Escobar, Madurga, Castellano, Velázquez, Del Villar et al., Risk score for predicting in-hospital mortality in COVID-19 (rim score), Diagnostics
Mathew, Agha, Albrecht, Goel, Mukherjee et al., Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery, Annals of Medicine and Surgery
Moniruzzaman, Ghosal, Das, Chakraborty, Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk/Akt/NFkB pathway, Biological Research
Mortezaee, Potes, Mirtavoos-Mahyari, Motevaseli, Shabeeb et al., Boosting immune system against cancer by melatonin: A mechanistic viewpoint, Life sciences
Pasricha, Colman, Centeno-Tablante, Garcia-Casal, Peña-Rosas, None
Ramlall, Zucker, Tatonetti, Melatonin is significantly associated with survival of intubated COVID-19 patients
Reiter, Mayo, Tan, Sainz, Jimenez et al., Melatonin as an antioxidant: under promises but over delivers, Journal of pineal research
Ren, Liu, Chen, Yin, Wang et al., Melatonin signaling in T cells: Functions and applications, Journal of pineal research
Reynolds, Dubocovich, Melatonin multifaceted pharmacological actions on melatonin receptors converging to abrogate COVID-19, Journal of Pineal Research
Shohrati, Mohammadi, Najafi, Sharifzadeh, Sharifnia et al., Evaluation of the Effects of Melatonin Supplementation on Coagulation in Patients with Haemorrhagic Stroke; A Randomized, Double-Blind, Controlled Trial, Frontiers in Emergency Medicine
Srinivasan, Mohamed, Kato, Melatonin in bacterial and viral infections with focus on sepsis: a review. Recent patents on endocrine, metabolic & immune drug discovery
Sung, Bae, Lee, Kim, Kim, The melatonin signaling pathway in a long-term memory in vitro study, Molecules
Yang, Cao, Du, Wu, Zhuang et al., Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis, Annals of translational medicine
Yang, Liu, Tao, Li, The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients, International immunopharmacology
Zhang, Wang, Ni, Di, Ma et al., COVID-19: Melatonin as a potential adjuvant treatment, Life sciences
Zhang, Yan, Tian, Li, Wang et al., Synthesis of a new water-soluble melatonin derivative with low toxicity and a strong effect on sleep aid, ACS omega
Zhou, Hou, Shen, Mehra, Kallianpur et al., A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19, PLoS biology
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