Safety, Tolerability and Efficacy and Dose Response of GLS-1027 in the Prevention of Severe Pneumonitis Caused by SARS-CoV-2 Infection

Kane et al., NCT04590547, NCT04590547, Apr 2025
Late treatmentRCT · NCT04590547 · 132 patients · multinational
Zenuzolac for COVID-19
Kane et al. NCT04590547 · April 2025
Higher mortality with zenuzolac
Not statistically significant · p = 0.34
RCT 132 hospitalized COVID-19 patients showing no significant difference in outcomes with zenuzolac (GLS-1027) treatment.
risk of death, 200.2% higher, RR 3.00, p = 0.34, treatment 46, control 44.
risk of death, 195.7% higher, RR 2.96, p = 1.00, treatment 1 of 46 (2.2%), control 0 of 44 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), 360mg.
risk of death, 204.8% higher, RR 3.05, p = 0.49, treatment 1 of 42 (2.4%), control 0 of 44 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), 120mg.
risk of no recovery, 0.7% higher, RR 1.01, p = 0.99, treatment 46, control 44.
risk of no recovery, 43.5% higher, RR 1.43, p = 1.00, treatment 3 of 46 (6.5%), control 2 of 44 (4.5%), 360mg.
risk of no recovery, 47.6% lower, RR 0.52, p = 1.00, treatment 1 of 42 (2.4%), control 2 of 44 (4.5%), NNT 46, 120mg.
hospitalization time, 1.1% lower, relative time 0.99, p = 0.87, treatment 46, control 44.
hospitalization time, 1.1% lower, relative time 0.99, p = 0.90, treatment mean 9.3 (±3.65) n=46, control mean 9.4 (±4.1) n=44, 360mg.
hospitalization time, 1.1% lower, relative time 0.99, p = 0.91, treatment mean 9.3 (±4.2) n=42, control mean 9.4 (±4.1) n=44, 120mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kane et al., 11 Apr 2025, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, preprint, 1 author, trial NCT04590547 (history). Contact: dkane@genels.us.
Zenuzolac (GLS-1027) is an oral, small molecule isoxazole immunomodulator that down-regulates NF-κB/p38-mediated pro-inflammatory cytokine production and Th17 responses.
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 200,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. IMA and WCH provide treatment protocols.
  or use drag and drop   
Submit