Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a prospective cohort study

{ 'indexed': {'date-parts': [[2022, 2, 17]], 'date-time': '2022-02-17T04:41:27Z', 'timestamp': 1645072887194}, 'reference-count': 53, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 2, 17]], 'date-time': '2022-02-17T00:00:00Z', 'timestamp': 1645056000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2022, 2, 17]], 'date-time': '2022-02-17T00:00:00Z', 'timestamp': 1645056000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'short-container-title': ['BMC Geriatr'], 'published-print': {'date-parts': [[2022, 12]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec>\n' ' <jats:title>Background</jats:title>\n' ' <jats:p>The primary risk factors for severe respiratory failure and death in ' 'the elderly hospitalized with COVID-19 remain unclear.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Objective</jats:title>\n' ' <jats:p>To determine the association of chronic diseases, chest computed ' 'tomography (CT), and laboratory tests with severe respiratory failure and mortality in older ' 'adults hospitalized with COVID-19.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Method</jats:title>\n' ' <jats:p>This was a prospective cohort with 201 hospitalized older adults with ' 'COVID-19. Chronic diseases, chest CT, laboratory tests, and other data were collected within ' 'the first 48\u2009h of hospitalization. Outcomes were progression to severe respiratory ' 'failure with the need of mechanical ventilation (SRF/MV) and death.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Results</jats:title>\n' ' <jats:p>The mean age was 72.7\u2009±\u20099.2\u2009years, and 63.2% were men. ' 'SRF/MV occurred in 16.9% (<jats:italic>p</jats:italic>\u2009&lt;\u20090.001), and death ' 'occurred in 8%. In the adjusted regression analyses, lung involvement over 50% [odds ratio ' '(OR): 3.09 (1.03–9.28; 0.043)], C-reactive protein (CRP)\u2009&gt;\u200980\u2009ng/mL [OR: ' '2.97 (0.99–8.93; 0.052)], Vitamin D\u2009&lt;\u200940\u2009ng/mL [OR: 6.41 (1.21–33.88; ' '0.029)], and hemoglobin &lt;\u200912\u2009g/mL [OR: 3.32 (1.20–9.20; 0.020)] were independent ' 'predictors for SFR/MV, while chronic atrial fibrillation [OR: 26.72 (3.87–184.11; 0.001)], ' 'cancer history [OR:8.32 (1.28–53.91; 0.026)] and IL-6\u2009&gt;\u200940\u2009pg/mL [OR:10.01 ' '(1.66–60.13; 0.012)] were independent predictors of death.</jats:p>\n' ' </jats:sec><jats:sec>\n' ' <jats:title>Conclusion</jats:title>\n' ' <jats:p>In hospitalized older adults with COVID-19, tomographic pulmonary ' 'involvement &gt;\u200950%, anemia, vitamin D below 40\u2009ng/mL, and CRP above 80\u2009mg/L ' 'were independent risk factors for progression to SRF/MV. The presence of chronic atrial ' 'fibrillation, previous cancer, IL-6\u2009&gt;\u200940\u2009pg/mL, and anemia were independent ' 'predictors of death.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1186/s12877-022-02776-3', 'type': 'journal-article', 'created': {'date-parts': [[2022, 2, 17]], 'date-time': '2022-02-17T04:25:44Z', 'timestamp': 1645071944000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': [ 'Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe ' 'respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a ' 'prospective cohort study'], 'prefix': '10.1186', 'volume': '22', 'author': [ {'given': 'Alberto Frisoli', 'family': 'Junior', 'sequence': 'first', 'affiliation': []}, {'given': 'Elaine', 'family': 'Azevedo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Angela Tavares', 'family': 'Paes', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eliene', 'family': 'Lima', 'sequence': 'additional', 'affiliation': []}, { 'given': 'João Carlos', 'family': 'Campos Guerra', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Sheila Jean Mc Neill', 'family': 'Ingham', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2022, 2, 17]]}, 'reference': [ { 'key': '2776_CR1', 'doi-asserted-by': 'publisher', 'unstructured': 'CDC COVID-19 Response Team. 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All participants or caregivers / family members ' 'signed the Informed Consent Form (ICF). The signing was performed in person by ' 'a member of the study team or through an electronic document sent to the ' 'participant, after a phone call in which the ICF was read and explained by a ' 'member of the study team. The project and Informed Consent Form (ICF) were ' 'approved by the Ethics Committee of the Hospital Israelita Albert Einstein and ' 'of Plataforma Brasil under the numbers: 4.082.096 e 4.186.636 .', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Not applicable.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare that they have no competing interests.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '132'}