Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All fluvoxamine studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchFluvoxamineFluvoxamine (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)

Jittamala et al., medRxiv, doi:10.1101/2024.01.16.24301337, PLATCOV, NCT05041907
Jan 2024  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
26th treatment shown to reduce risk in November 2021
 
*, now known with p = 0.00014 from 21 studies, recognized in 3 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
RCT 271 low-risk outpatients, showing improved viral clearance with fluoxetine in low-risk adult outpatients.
Jittamala et al., 18 Jan 2024, multiple countries, preprint, 43 authors, study period 5 April, 2022 - 8 May, 2023, trial NCT05041907 (history) (PLATCOV). Contact: william@tropmedres.ac, nickw@tropmedres.ac.
This PaperFluvoxamineAll
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)
MD Podjanee Jittamala, MBBS Simon Boyd, MBBS William Hk Schilling, James A Watson, MD Thundon Ngamprasertchai, MD Tanaya Siripoon, MD Viravarn Luvira, PhD Elizabeth M Batty, PhD Phrutsamon Wongnak, Lisia M Esper, Pedro J Almeida, MD Cintia Cruz, Fernando R Ascencao, Renato S Aguiar, PhD Najia K Ghanchi, James J Callery, MBBS Shivani Singh, PhD Varaporn Kruabkontho, MBA Thatsanun Ngernseng, Pharm.D Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, MD Borimas Hanboonkunupakarn, MD Kittiyod Poovorawan, MD Manus Potaporn, MD Attasit Srisubat, MD Bootsakorn Loharjun, Walter Rj Taylor, Farah Qamar, Abdul Momin Kazi, M Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, PhD Kesinee Chotivanich, PhD Mallika Imwong, MBBS Sasithon Pukrittayakamee, Arjen M Dondorp, Nicholas Pj Day, MD Mauro M Teixeira, MD Watcharapong Piyaphanee, MD Weerapong Phumratanaprapin, Nicholas J White
doi:10.1101/2024.01.16.24301337
Background The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine were repurposed for the treatment of early COVID-19 based on their antiviral activity in vitro, and observational and clinical trial evidence suggesting they prevented progression to severe disease. However, these SSRIs have not been recommended in guidelines and their antiviral activity in vivo has not been characterised. Methods PLATCOV is an open-label, multicentre, phase 2, randomised, controlled, adaptive pharmacometric platform trial running in Thailand, Brazil, Pakistan, and Laos. We recruited lowrisk adult outpatients aged 18-50 with early symptomatic COVID-19 (symptoms <4 days). Patients Added value of the study We showed that in early COVID-19 illness the SSRI fluoxetine has weak antiviral activity in vivo. This activity is substantially less than other available antivirals such as ritonavir-boosted nirmatrelvir and molnupiravir. The pharmacometric approach described here provides a quantitative measure of in vivo antiviral effects with tractable sample sizes. Implications of available evidence Fluoxetine has weak in vivo antiviral activity in early COVID-19. This is insufficient for treatment but, as less antiviral activity is required to prevent an infection, fluoxetine could still be beneficial in prophylaxis.
Contributors PJ-investigation, methodology, project administration, supervision, validation, and writingoriginal draft. SB-investigation, methodology, project administration, writing-original draft. PJ and SB contributed equally. WHKS-funding acquisition, investigation, methodology, project administration, supervision, validation, and writing-original draft. JAW-conceptualisation, data curation, formal analysis, funding acquisition, methodology, visualisation, and writing-original draft. TN, TS, VL-Investigation, methodology, supervision. EMB-data curation, formal analysis, visualisation. PW-data curation, formal analysis, visualisation, and writing-original draft. RA, FA, NG-formal analysis, investigation. LE, PA, CC, JJC, SS, VK, TN, JT, FQ, AMK -methodology, investigation, project administration. WM, KS, AP-investigation, methodology. BH, KP-
References
Bramante, Huling, Tignanelli, Randomized trial of metformin, ivermectin, and fluvoxamine for Covid-19, N Engl J Med
Butler, Hobbs, Gbinigie, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial, Lancet
Clelland, Ramiah, Steinberg, Clelland, Analysis of the impact of antidepressants and other medications on COVID-19 infection risk in a chronic psychiatric in-patient cohort, B J Psych Open
Elias, Khan, Stadler, Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: A systematic review and meta-analysis, medRxiv
Eugene, Fluoxetine pharmacokinetics and tissue distribution suggest a possible role in reducing SARS-CoV-2 titers, Research
Fred, Kuivanen, Ugurlu, Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine shows antiviral activity against the novel variants in vitro, Front. Pharmacol
Hammond, Leister-Tebbe, Gardner, Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19, N Engl J Med
Hoertel, Sánchez-Rico, Gulbins, Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19: an observational multicenter study, Transl Psychiatry
Hoertel, Sánchez-Rico, Kornhuber, Antidepressant use and its association with 28-day mortality in inpatients with SARS-CoV-2: support for the FIASMA model against COVID-19, J Clin Med
Hoertel, Sánchez-Rico, Vernet, Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study, Mol. Psychiatry
Jittamala, Schilling, Watson, Clinical antiviral efficacy of remdesivir and casirivimab/imdevimab against the SARS-CoV-2 Delta and Omicron variants, medRxiv
Lenze, Mattar, Zorumski, Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial, JAMA
Luvira, Schilling, Jittamala, Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled adaptive platform trial, Research Square, doi:10.21203/rs.3.rs-2675703/v1
Mccarthy, Naggie, Boulware, Effect of fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19: a randomized clinical trial, JAMA
Oskotsky, Marić, Tang, Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants, JAMA Netw Open
Parienti, De Grooth, Clinical relevance of nasopharyngeal SARS-CoV-2 viral load reduction in outpatients with COVID-19, J Antimicrob Chemother
Pauletto, Delgado, Da Rocha, Acid sphingomyelinase (ASM) and COVID-19: A review of the potential use of ASM inhibitors against SARS-CoV-2, Cell Biochem. Funct
Reiersen, Mattar, Ignacio, The STOP COVID 2 Study: Fluvoxamine vs Placebo for Outpatients with Symptomatic COVID-19, a Fully Remote Randomized Controlled Trial, Open Forum Infect Dis
Reis, Moreira-Silva, Silva, Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial, Lancet Glob Hlth
Reis, Silva, Silva, Oral Fluvoxamine with Inhaled Budesonide for Treatment of Early-Onset COVID-19: A Randomized Platform Trial, Ann Intern Med
Sanderson, Hisner, Ia, A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, Nature
Schilling, Jittamala, Watson, Antiviral efficacy of molnupiravir versus ritonavirboosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial, Lancet Infect Dis
Schilling, Jittamala, Watson, Pharmacometric assessment of the in vivo antiviral activity of ivermectin in early symptomatic COVID-19, eLife
Siripongboonsitti, Ungtrakul, Tawinprai, Efficacy of combination therapy of fluvoxamine and favipiravir vs favipiravir monotherapy to prevent severe COVID-19 among mild to moderate COVID-19 patients: Open-label randomized controlled trial (EFFaCo study), Int J Infect Dis
Stewart, Rebolledo, Mourad, Higher-Dose Fluvoxamine and Time to Sustained Recovery in Outpatients With COVID-19: The ACTIV-6 Randomized Clinical Trial, JAMA
Vehtari, Gelman, Gabry, Practical Bayesian model evaluation using leave-one-out crossvalidation and WAIC, Stat Comput
Watson, Kissler, Day, Grad, White, Characterizing SARS-CoV-2 Viral Clearance Kinetics to Improve the Design of Antiviral Pharmacometric Studies, Antimicrob Agents Chemother
Wongnak, Schilling, Jittamala, Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of phase 2 antiviral studies
Zimniak, Kirschner, Hilpert, The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue, Sci. Rep
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit