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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Recovery time -1% Improvement Relative Risk Azvudine for COVID-19  Jin et al.  EARLY TREATMENT Is early treatment with azvudine beneficial for COVID-19? Retrospective 481 patients in China No significant difference in recovery Jin et al., J. Clinical Pharmacology a.., Feb 2024 Favors azvudine Favors control

Effects of Azvudine on the Low-Risk Patients Infected with COVID-19 Omicron Variants: A Retrospective Case-Control Study

Jin et al., Journal of Clinical Pharmacology and Therapeutics, 5:1
Feb 2024  
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Azvudine for COVID-19
41st treatment shown to reduce risk in July 2023
*, now known with p = 0.00014 from 18 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Retrospective 481 low-risk COVID-19 patients in China showing no significant difference in recovery or symptomatic severity with azvudine, but slightly lower total viral load.
recovery time, 0.7% higher, relative time 1.01, p = 0.90, treatment mean 12.21 (±2.84) n=33, control mean 12.12 (±2.82) n=33.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jin et al., 12 Feb 2024, retrospective, China, peer-reviewed, 14 authors.
This PaperAzvudineAll
Effects of Azvudine on the Low-Risk Patients Infected with COVID-19 Omicron Variants: A Retrospective Case-Control Study Research Article
Xiaogao Jin, Qinjun Chu, Jie Wang, Chenxi Zhang, Hailong Bing, Liwei Sun, Wenchuan Guan, Hang Bao, Jieshi Ba, Dachao Yun, Dan Wang, Jiwei Wang, Ningwei Yin, Hongkai Lian
Objective: To evaluate the efficacy and safety of Azvudine in treatment of the patients infected with COVID-19 Omicron variants. Methods: This study included the discharged patients after COVID-19 infection from October 17 to November 17 in 2022 in Zhengzhou Central Hospital. The patients were divided into two groups, the Symptomatic Treatment group (ST) and the Symptomatic Treatment and oral Azvudine (STA) groups to evaluate the efficacy and safety of Azvudine. Results: A total 481 patients were included. The recovery time had no correlation with oral Azvudine (Beta=1.920, p=0.056) in a low-fit multiple linear regression with the data-available patients (R2=0.039, F=3.117, p=0.027). No significant differences were found in the recovery time (12.12 ± 2.83 vs. 12.21 ± 2.84, n=33, P=0.897) and symptomatic severity between the two groups after 1:1 matched. However, STA groups had lower total viral load than ST group after the final matching (28.03 ± 4.72 vs. 25.53 ± 5.32, n=33, P=0.048). Seventeen of 206 patients reported Azvudine-related adverse effects and stopped Azvudine. Conclusion: Azvudine had little effect on the low-risk patients with Omicron infection to improve recovery time and symptoms. However, it could slightly decrease total viral load during the first 5 days after administration while being relatively safe for oral use overall.
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