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Povidone iodine, hydrogen peroxide and chlorhexidine mouthwashes reduce SARS-CoV2 burden in whole mouth fluid and respiratory droplets

Jayaraman et al., medRxiv, doi:10.1101/2021.02.25.21252488
Mar 2021  
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Study of SARS-CoV-2 burden in whole mouth fluid and respiratory droplets with povidone iodine, hydrogen peroxide, and chlorhexidine mouthwashes in 36 hospitalized COVID-19 patients using PCR and rapid antigen testing. There were significant reductions in SARS-CoV-2 burden with all treatments in both respiratory droplets and whole mouth fluid.
Analysis of short-term changes in viral load using PCR may not detect effective treatments because PCR is unable to differentiate between intact infectious virus and non-infectious or destroyed virus particles. For example Alemany, Tarragó‐Gil perform RCTs with cetylpyridinium chloride (CPC) mouthwash that show no difference in PCR viral load, however there was significantly increased detection of SARS-CoV-2 nucleocapsid protein, indicating viral lysis. CPC inactivates SARS-CoV-2 by degrading its membrane, exposing the nucleocapsid of the virus. To better estimate changes in viral load and infectivity, methods like viral culture or antigen detection that can differentiate intact vs. degraded virus are preferred.
This study is excluded in the after exclusion results of meta analysis: study only provides short-term viral load results.
This study includes chlorhexidine, hydrogen peroxide, and povidone-iodine.
Jayaraman et al., 1 Mar 2021, prospective, India, preprint, 12 authors.
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Abstract: medRxiv preprint doi: https://doi.org/10.1101/2021.02.25.21252488; this version posted March 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Povidone iodine, hydrogen peroxide and chlorhexidine mouthwashes reduce SARS-CoV2 burden in whole mouth fluid and respiratory droplets Bagavad Gita Jayaraman1*, Gunaseelan Rajan1, Priya Kannian2*, Chandra Lavanya4, Krittika Ravichandran1, Nagalingeswaran Kumarasamy3, Kannan Ranganathan4, Veeraraghavan Aswini2, Pasuvaraj Mahanathi2, Stephen Challacombe5, Jennifer Webster-Cyriaque6, Newell W Johnson1,3,5,7 1 2 Chennai Dental Research Foundation, Chennai, India VHS Laboratory Services, Department of Clinical Research, VHS Hospital, Chennai, India 3 VHS-Infectious Diseases Medical Centre, VHS Hospital, Chennai, India 4 Department of Oral Pathology, Ragas Dental College and Hospital, Chennai, India 5 Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, UK 6 University of North Carolina, Chapel Hill, USA 7 Menzies Health Institute Queensland, Griffith University, Queensland, Australia Address for Correspondence: * Dr. Bagavad Gita Jayaraman Research Scientist Chennai Dental Research Foundation No. 56, Dr. R. K. Salai 6th Floor, Mylapore Chennai – 600004 Tamil Nadu, India Ph: 91-44-42103440 Email: gita70.geetha@gmail.com * Dr. Priya Kannian Scientist & Head Department of Clinical Research VHS Hospital Rajiv Gandhi Salai Taramani, Chennai – 600113 Tamil Nadu, India Ph: 91-44-22541972 Email: priyakannian@gmail.com Word count: 599 words 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2021.02.25.21252488; this version posted March 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license .
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