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All Studies   Meta Analysis    Recent:   

Clinical course of COVID-19 patients treated with ECMO: A multicenter study in Daegu, South Korea

Jang et al., Heart & Lung, doi:10.1016/j.hrtlng.2020.10.010
Dec 2020  
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0 0.5 1 1.5 2+ Recovery 78% Improvement Relative Risk Vitamin B12 for COVID-19  Jang et al.  ECMO PATIENTS Is late treatment with vitamin B12 beneficial for COVID-19? Retrospective 19 patients in South Korea (February - April 2020) Improved recovery with vitamin B12 (p=0.041) c19early.org Jang et al., Heart & Lung, December 2020 Favors vitamin B12 Favors control
34th treatment shown to reduce risk in February 2022
 
*, now known with p = 0.023 from 4 studies.
Lower risk for recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Retrospective 19 COVID-19 ECMO patients in South Korea, showing a higher rate of weaning from ECMO with vitamin B12 treatment, without statistical significance. Authors perform multivariate analysis but do not provide full results, only reporting p > 0.05.
Study covers vitamin B12 and vitamin C.
risk of no recovery, 78.3% lower, RR 0.22, p = 0.04, treatment 1 of 6 (16.7%), control 10 of 13 (76.9%), NNT 1.7, weaning from ECMO.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Jang et al., 16 Dec 2020, retrospective, South Korea, peer-reviewed, median age 63.0, 10 authors, study period February 2020 - April 2020. Contact: whiteuri09@gmail.com.
This PaperVitamin B12All
Clinical course of COVID-19 patients treated with ECMO: A multicenter study in Daegu, South Korea
M.D Woo Sung Jang, M.D Jaebum Kim, M.D. c Jonghyun Baek, M.D Hanna Jung, M.D Jae Seok Jang, M.D. e Jae Seok Park, M.D. f Tak-Hyuk Oh, M.D Se Yong Jang, M.D Yun Seok Kim, M.D Yong Shik Kwon
Heart & Lung, doi:10.1016/j.hrtlng.2020.10.010
Background: The COVID-19 pandemic has caused an epidemic of critical patients, some of whom have been treated with extracorporeal membrane oxygenation (ECMO). This purpose of study is to describe the clinical course of COVID-19 patients treated with ECMO. Methods: A multicentered study of critical patients with COVID-19 treated at six hospitals in Daegu was conducted between January and April 2020. Results: Among the 80 patients receiving mechanical ventilation support, 19 (24%) were treated with ECMO included (median age 63.0 years). Eight of the 19 patients (42%) were weaned off ECMO (9.8 days, IQR 7.0-13.7). Among them, four patients were also weaned off mechanical ventilation (33.4 days, IQR 29.3 -35.7), three were still receiving mechanical ventilation (50.9 days), and one expired after ECMO weaning. According to the univariate analysis, the factor that was associated with successful ECMO weaning was vitamin B12 treatment (p = 0.028). Conclusions: During the COVID-19 epidemic, ECMO weaning and mortality rates were 42% and 58%, respectively.
Ethical approval All studies were approved by the national ethics committee. Declaration of Competing Interests The authors have no conflicts of interest to declare.
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Late treatment
is less effective
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