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0 0.5 1 1.5 2+ Mortality 88% Improvement Relative Risk Ventilation 90% Progression -4% Selenium for COVID-19  Im et al.  Sufficiency Are selenium levels associated with COVID-19 outcomes? Retrospective 49 patients in South Korea Lower ventilation with higher selenium levels (p=0.028) Im et al., Int. J. Infect. Dis., August 2020 Favors selenium Favors control

Nutritional status of patients with COVID-19

Im et al., Int. J. Infect. Dis., doi:10.1016/j.ijid.2020.08.018
Aug 2020  
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Analysis of 50 hospitalized COVID-19 patients in South Korea showing 42% of patients with selenium deficiency, and lower mechanical ventilation with selenium sufficiency.
This study includes selenium and vitamin D.
risk of death, 87.5% lower, RR 0.12, p = 0.07, high selenium levels (≥60μg/L) 0 of 28 (0.0%), low selenium levels (<60μg/L) 3 of 21 (14.3%), NNT 7.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 90.3% lower, RR 0.10, p = 0.03, high selenium levels (≥60μg/L) 0 of 28 (0.0%), low selenium levels (<60μg/L) 4 of 21 (19.0%), NNT 5.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of progression, 3.8% higher, RR 1.04, p = 1.00, high selenium levels (≥60μg/L) 18 of 28 (64.3%), low selenium levels (<60μg/L) 13 of 21 (61.9%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Im et al., 11 Aug 2020, retrospective, South Korea, peer-reviewed, 6 authors.
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Nutritional status of patients with COVID-19
Jae Hyoung Im, Young Soo Je, Jihyeon Baek, Moon-Hyun Chung, Hea Yoon Kwon, Jin-Soo Lee
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2020.08.018
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Ethical approval This study was approved by the local ethics committee, which waived the need for informed consent. Conflict of interest All authors declare no conflict of interest related to this study. CRediT authorship contribution statement Jae Hyoung Im: Conceptualization, Writing -original draft. Young Soo Je: Writing -review & editing. Jihyeon Baek: Writingreview & editing. Moon-Hyun Chung: Writing -review & editing. Hea Yoon Kwon: Writing -review & editing, Supervision. Jin-Soo Lee: Conceptualization, Supervision. Appendix A. Supplementary data Supplementary material related to this article can be found, in the online version, at doi: ijid.2020.08.018.
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