Effect of zinc supplementation on symptom reduction and length of hospital stay among pediatric patients with Coronavirus Disease 2019 (COVID-19)
et al., Saudi Pharmaceutical Journal, doi:10.1016/j.jsps.2023.02.011
, Effect of zinc supplementation on symptom reduction and length of hospital stay among pediatric patients with.., Saudi Pharmaceutical Journal, doi:10.1016/j.jsps.2023.02.011
Retrospective 101 hospitalized pediatric patients in Saudi Arabia, showing zinc treatment associated with lower respiratory failure and shorter hospitalization in unadjusted results. Patients receiving zinc were older. Authors note elevated serum creatinine and the possibility of kidney injury.
This study is excluded in the after exclusion results of meta
analysis:
excessive unadjusted differences between groups.
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risk of death, 87.6% lower, RR 0.12, p = 0.13, treatment 0 of 44 (0.0%), control 4 of 57 (7.0%), NNT 14, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
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risk of mechanical ventilation, 26.0% lower, RR 0.74, p = 0.75, treatment 4 of 44 (9.1%), control 7 of 57 (12.3%), NNT 31.
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risk of ICU admission, 2.8% lower, RR 0.97, p = 1.00, treatment 9 of 44 (20.5%), control 12 of 57 (21.1%), NNT 167.
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respiratory failure, 72.7% lower, RR 0.27, p = 0.004, treatment 4 of 44 (9.1%), control 19 of 57 (33.3%), NNT 4.1.
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hospitalization time, 28.6% lower, relative time 0.71, p = 0.02, treatment 44, control 57.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Ibrahim Alhajjaji et al., 4 Mar 2023, retrospective, Saudi Arabia, peer-reviewed, 8 authors, study period 1 March, 2020 - 31 December, 2021.
Contact:
ghufran.alhajjaji@gmail.com, nealotaibi@uqu.edu.sa, ph.nada.abutaleb@gmail.com, mmiteb@psmmc.med.sa, ph.alhajjaji@gmail.com, assalotaibi@uqu.edu.sa, bmalshehail@iau.edu.sa, me.alotaibi@psmmc.med.sa.
Abstract: Journal Pre-proofs
Original article
Effect of zinc supplementation on symptom reduction and length of hospital
stay among pediatric patients with Coronavirus Disease 2019 (COVID-19)
Ghufran Ibrahim Alhajjaji, Nouf Alotaibi, Nada Abutaleb, Mishal M.
Alotaibi, Abdulrahman Alhajjaji, Abdulmalik S. Alotaibi, Bashayer
Alshehail, Moawad E. Alotaibi
PII:
DOI:
Reference:
S1319-0164(23)00041-5
https://doi.org/10.1016/j.jsps.2023.02.011
SPJ 1587
To appear in:
Saudi Pharmaceutical Journal
Received Date:
Revised Date:
Accepted Date:
4 December 2022
18 January 2023
26 February 2023
Please cite this article as: Ibrahim Alhajjaji, G., Alotaibi, N., Abutaleb, N., Alotaibi, M.M., Alhajjaji, A.,
Alotaibi, A.S., Alshehail, B., Alotaibi, M.E., Effect of zinc supplementation on symptom reduction and length of
hospital stay among pediatric patients with Coronavirus Disease 2019 (COVID-19), Saudi Pharmaceutical
Journal (2023), doi: https://doi.org/10.1016/j.jsps.2023.02.011
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© 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
Effect of zinc supplementation on symptom reduction and length of hospital stay among
pediatric patients with Coronavirus Disease 2019 (COVID-19)
Ghufran Ibrahim Alhajjaji 1, Nouf Alotaibi*2 Nada Abutaleb, Mishal M. Alotaibi3, Abdulrahman
Alhajjaji4 Abdulmalik S. Alotaibi2, Bashayer Alshehail5, Moawad E. Alotaibi3
1. Ghufran Ibrahim, Pharm.D, Department of Pharmaceutical Care, Maternity and Children
Hospital, Makkah, Saudi Arabia. Email: Ghufran.alhajjaji@gmail.com
2. * Nouf Alotaibi, (Corresponding author), Pharm.D, Umm Al-Qura university, Clinical
pharmacy department, college of pharmacy, Makkah, Saudi Arabia. ORCID:
https://orcid.org/0000-0001-7029-3089 email: Nealotaibi@uqu.edu.sa mobile:
00966533694235
1. Nada Abutaleb, Pharm.D, Department of Pharmaceutical Care, Maternity and Children
Hospital, Makkah, Saudi Arabia. Email: Ph.nada.abutaleb@gmail.com
3. Mishal M. Alotaibi; MD, Family Medicine, Prince Sultan Military Medical City, Riyadh, Saudi
Arabia. Email: mmiteb@psmmc.med.sa
4. Abdulrahman Alhajjaji, Pharm.D, College of Pharmacy, Umm Al-Qura University, Makkah,
Saudi Arabia. Email: Ph.alhajjaji@gmail.com
2. Abdulmalik Alotaibi, Pharm.D, Umm Al-Qura university, Clinical pharmacy department,
college of pharmacy, Makkah, Saudi Arabia. Email: assalotaibi@uqu.edu.sa
5. Bashayer Alshehail, Pharm.D, Pharmacy Practice Department, College of Clinical Pharmacy,
Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia, email:
bmalshehail@iau.edu.sa
3. Moawad Alotaibi; MD, Family Medicine, Prince Sultan Military Medical City, Riyadh, Saudi
Arabia. Email: me.alotaibi@psmmc.med.sa
Effect of zinc supplementation on symptom reduction and length of hospital stay among
pediatric patients with Coronavirus Disease 2019 (COVID-19)
Abstract
Objectives: Zinc is considered an essential multipurpose trace element because of its ability..
Late treatment
is less effective
is less effective
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