Effect of zinc supplementation on symptom reduction and length of hospital stay among pediatric patients with Coronavirus Disease 2019 (COVID-19)

Ibrahim Alhajjaji et al., Saudi Pharmaceutical Journal, doi:10.1016/j.jsps.2023.02.011

Mar 2023

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Retrospective 101 hospitalized pediatric patients in Saudi Arabia, showing zinc treatment associated with lower respiratory failure and shorter hospitalization in unadjusted results. Patients receiving zinc were older. Authors note elevated serum creatinine and the possibility of kidney injury. This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.

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risk of death, 87.6% lower, RR 0.12, p = 0.13, treatment 0 of 44 (0.0%), control 4 of 57 (7.0%), NNT 14, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

risk of mechanical ventilation, 26.0% lower, RR 0.74, p = 0.75, treatment 4 of 44 (9.1%), control 7 of 57 (12.3%), NNT 31.

risk of ICU admission, 2.8% lower, RR 0.97, p = 1.00, treatment 9 of 44 (20.5%), control 12 of 57 (21.1%), NNT 167.

respiratory failure, 72.7% lower, RR 0.27, p = 0.004, treatment 4 of 44 (9.1%), control 19 of 57 (33.3%), NNT 4.1.

hospitalization time, 28.6% lower, relative time 0.71, p = 0.02, treatment 44, control 57.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Ibrahim Alhajjaji et al., 4 Mar 2023, retrospective, Saudi Arabia, peer-reviewed, 8 authors, study period 1 March, 2020 - 31 December, 2021.

Contact: ghufran.alhajjaji@gmail.com, nealotaibi@uqu.edu.sa, ph.nada.abutaleb@gmail.com, mmiteb@psmmc.med.sa, ph.alhajjaji@gmail.com, assalotaibi@uqu.edu.sa, bmalshehail@iau.edu.sa, me.alotaibi@psmmc.med.sa.

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Effect of zinc supplementation on symptom reduction and length of hospital stay among pediatric patients with Coronavirus Disease 2019 (COVID-19)

Ghufran Ibrahim Alhajjaji, Nouf Alotaibi, Nada Abutaleb, Mishal M Alotaibi, Abdulrahman Alhajjaji, Abdulmalik S Alotaibi, Bashayer Alshehail, Moawad E Alotaibi

Saudi Pharmaceutical Journal, doi:10.1016/j.jsps.2023.02.011

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