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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Oxygen therapy 80% Improvement Relative Risk Hospitalization 40% Clinical scale >1 67% Recovery time 15% SIRS, day 7 67% SIRS, day 14 67% Viral clearance, day 28 80% Viral clearance, day 21 50% Viral clearance, day 14 -57% Viral clearance, day 7 -28% Thermotherapy  Huang et al.  LATE TREATMENT  RCT Is late treatment with thermotherapy beneficial for COVID-19? RCT 50 patients in China (February - April 2020) Improved recovery with thermotherapy (p=0.0016) c19early.org Huang et al., Frontiers in Medicine, Feb 2021 Favors thermotherapy Favors control

Efficacy and safety of ultra-short wave diathermy on COVID-19 pneumonia: a pioneering study

Huang et al., Frontiers in Medicine, doi:10.3389/fmed.2023.1149250 (date from preprint), ChiCTR2000029972
Feb 2021  
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42nd treatment shown to reduce risk in December 2023
 
*, now known with p = 0.026 from 4 studies.
Lower risk for recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
RCT 50 hospitalized COVID-19 pneumonia patients showing faster recovery with ultra-short wave diathermy (USWD). The USWD group received standard treatment plus USWD applied to the chest for 10 minutes twice daily for 12 days. The USWD group had significantly faster clinical recovery by 6.7 days, lower systemic inflammation, and better outcomes on the 7-point clinical status scale on days 21 and 28 compared to the control group receiving only standard treatment. There was no significant difference in SARS-CoV-2 viral clearance. Pulmonary fibrosis observed prior to treatment was recovered in most patients in both groups, alleviating concerns over potential harms of USWD.
Baseline severe cases were more common in the treatment group, 52 vs. 28%.
risk of oxygen therapy, 80.0% lower, RR 0.20, p = 0.49, treatment 0 of 25 (0.0%), control 2 of 25 (8.0%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 28.
risk of hospitalization, 40.0% lower, RR 0.60, p = 0.70, treatment 3 of 25 (12.0%), control 5 of 25 (20.0%), NNT 12, day 28.
clinical scale >1, 66.7% lower, RR 0.33, p = 0.002, treatment 6 of 25 (24.0%), control 18 of 25 (72.0%), NNT 2.1, day 28.
recovery time, 15.4% lower, relative time 0.85, p = 0.04, treatment 25, control 25.
SIRS, 66.7% lower, RR 0.33, p = 0.03, treatment 25, control 25, inverted to make RR<1 favor treatment, day 7.
SIRS, 66.7% lower, RR 0.33, p = 0.002, treatment 25, control 25, inverted to make RR<1 favor treatment, day 14.
risk of no viral clearance, 80.0% lower, RR 0.20, p = 0.49, treatment 0 of 25 (0.0%), control 2 of 25 (8.0%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 28.
risk of no viral clearance, 50.0% lower, RR 0.50, p = 0.46, treatment 3 of 25 (12.0%), control 6 of 25 (24.0%), NNT 8.3, day 21.
risk of no viral clearance, 57.1% higher, RR 1.57, p = 0.38, treatment 11 of 25 (44.0%), control 7 of 25 (28.0%), day 14.
risk of no viral clearance, 27.8% higher, RR 1.28, p = 0.14, treatment 23 of 25 (92.0%), control 18 of 25 (72.0%), day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Huang et al., 1 Feb 2021, Randomized Controlled Trial, China, peer-reviewed, 8 authors, study period 18 February, 2020 - 20 April, 2020, diathermy, trial ChiCTR2000029972. Contact: chenhong1129@hotmail.com, chenhong1129@hust.edu.cn.
This PaperThermotherapyAll
Efficacy and safety of ultra-short wave diathermy on COVID-19 pneumonia: a pioneering study
Liangjiang Huang, Qian Li, Sayed Zulfiqar Ali Shah, Mohammad Nasb, Iftikhar Ali, Bin Chen, Lingfeng Xie, Hong Chen
Frontiers in Medicine, doi:10.3389/fmed.2023.1149250
Background: The ultra-short wave diathermy (USWD) is widely used to ameliorate inflammation of bacterial pneumonia, however, for COVID-19 pneumonia, USWD still needs to be verified. This study aimed to investigate the efficacy and safety of USWD in COVID-19 pneumonia patients. Methods: This was a single-center, evaluator-blinded, randomized controlled trial. Moderate and severe COVID-19 patients were recruited between 18 February and 20 April 2020. Participants were randomly allocated to receive USWD + standard medical treatment (USWD group) or standard medical treatment alone (control group). The negative conversion rate of SARS-CoV-2 and Systemic Inflammatory Response Scale (SIRS) on days 7, 14, 21, and 28 were assessed as primary outcomes. Secondary outcomes included time to clinical recovery, the 7-point ordinal scale, and adverse events. Results: Fifty patients were randomized (USWD, 25; control, 25), which included 22 males (44.0%) and 28 females (56.0%) with a mean (SD) age of 53 ± 10.69. The rates of SARS-CoV-2 negative conversion on day 7 (p = 0.066), day 14 (p = 0.239), day 21 (p = 0.269), and day 28 (p = 0.490) were insignificant. However, systemic inflammation by SIRS was ameliorated with significance on day 7 (p = 0.030), day 14 (p = 0.002), day 21 (p = 0.003), and day 28 (p = 0.011). Time to clinical recovery (USWD 36.84 ± 9.93 vs. control 43.56 ± 12.15, p = 0.037) was significantly shortened with a between-group difference of 6.72 ± 3.14 days. 7-point ordinal scale on days 21 and 28 showed significance (p = 0.002, 0.003), whereas the difference on days 7 and 14 was insignificant (p = 0.524, 0.108). In addition, artificial intelligenceassisted CT analysis showed a greater decrease in the infection volume in the USWD group, without significant between-group differences. No treatmentassociated adverse events or worsening of pulmonary fibrosis were observed in either group. Conclusion: Among patients with moderate and severe COVID-19 pneumonia, USWD added to standard medical treatment could ameliorate systemic inflammation and shorten the duration of hospitalization without causing any adverse effects.
Ethics statement The studies involving human participants were reviewed and approved by The ethics committee of the Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (certificate of approval number: TJ-C20200127). The patients/participants provided their written informed consent to participate in this study. Author contributions HC contributed to the supervision, drafting, and finalizing of the study. LH, QL, and SS equally contributed to compiling and describing the results. Moreover, authors LH and QL contributed to designing the CRF, medical history forms development, data collection, and interpretation. SS and MN contributed to writing and formatting the manuscript. LX designed the USWD treatment protocol, while BC did the CT scan analysis. IA contributed to data analysis. All authors contributed to the article and approved the submitted version. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary..
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{ 'DOI': '10.3389/fmed.2023.1149250', 'ISSN': ['2296-858X'], 'URL': 'http://dx.doi.org/10.3389/fmed.2023.1149250', 'abstract': '<jats:sec><jats:title>Background</jats:title><jats:p>The ultra-short wave diathermy (USWD) is ' 'widely used to ameliorate inflammation of bacterial pneumonia, however, for COVID-19 ' 'pneumonia, USWD still needs to be verified. This study aimed to investigate the efficacy and ' 'safety of USWD in COVID-19 pneumonia ' 'patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This was a ' 'single-center, evaluator-blinded, randomized controlled trial. Moderate and severe COVID-19 ' 'patients were recruited between 18 February and 20 April 2020. Participants were randomly ' 'allocated to receive USWD + standard medical treatment (USWD group) or standard medical ' 'treatment alone (control group). The negative conversion rate of SARS-CoV-2 and Systemic ' 'Inflammatory Response Scale (SIRS) on days 7, 14, 21, and 28 were assessed as primary ' 'outcomes. Secondary outcomes included time to clinical recovery, the 7-point ordinal scale, ' 'and adverse ' 'events.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Fifty patients ' 'were randomized (USWD, 25; control, 25), which included 22 males (44.0%) and 28 females ' '(56.0%) with a mean (SD) age of 53 ± 10.69. The rates of SARS-CoV-2 negative conversion on ' 'day 7 (<jats:italic>p</jats:italic>\u2009=\u20090.066), day 14 ' '(<jats:italic>p</jats:italic>\u2009=\u20090.239), day 21 (<jats:italic>p</jats:italic>\u2009' '=\u20090.269), and day 28 (<jats:italic>p</jats:italic>\u2009=\u20090.490) were ' 'insignificant. However, systemic inflammation by SIRS was ameliorated with significance on ' 'day 7 (<jats:italic>p</jats:italic>\u2009=\u20090.030), day 14 ' '(<jats:italic>p</jats:italic>\u2009=\u20090.002), day 21 (<jats:italic>p</jats:italic>\u2009' '=\u20090.003), and day 28 (<jats:italic>p</jats:italic>\u2009=\u20090.011). Time to clinical ' 'recovery (USWD 36.84\u2009±\u20099.93 vs. control 43.56\u2009±\u200912.15, ' '<jats:italic>p</jats:italic>\u2009=\u20090.037) was significantly shortened with a ' 'between-group difference of 6.72\u2009±\u20093.14\u2009days. 7-point ordinal scale on days 21 ' 'and 28 showed significance (<jats:italic>p</jats:italic>\u2009=\u20090.002, 0.003), whereas ' 'the difference on days 7 and 14 was insignificant (<jats:italic>p</jats:italic>\u2009=\u2009' '0.524, 0.108). In addition, artificial intelligence-assisted CT analysis showed a greater ' 'decrease in the infection volume in the USWD group, without significant between-group ' 'differences. No treatment-associated adverse events or worsening of pulmonary fibrosis were ' 'observed in either ' 'group.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Among patients ' 'with moderate and severe COVID-19 pneumonia, USWD added to standard medical treatment could ' 'ameliorate systemic inflammation and shorten the duration of hospitalization without causing ' 'any adverse effects.</jats:p><jats:p><jats:bold>Clinical Trial Registration</jats:bold>: ' '<jats:ext-link>chictr.org.cn</jats:ext-link>, identifier ' 'ChiCTR2000029972.</jats:p></jats:sec>', 'alternative-id': ['10.3389/fmed.2023.1149250'], 'author': [ {'affiliation': [], 'family': 'Huang', 'given': 'Liangjiang', 'sequence': 'first'}, {'affiliation': [], 'family': 'Li', 'given': 'Qian', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Shah', 'given': 'Sayed Zulfiqar Ali', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Nasb', 'given': 'Mohammad', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Ali', 'given': 'Iftikhar', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Chen', 'given': 'Bin', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Xie', 'given': 'Lingfeng', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Chen', 'given': 'Hong', 'sequence': 'additional'}], 'container-title': 'Frontiers in Medicine', 'container-title-short': 'Front. 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December 16th, 2021 ' 'to January 31st, 2022', 'author': 'Olaiz-Fernandez', 'doi-asserted-by': 'publisher', 'first-page': '102361', 'journal-title': 'Travel Med Infect Dis', 'key': 'ref6', 'volume': '49', 'year': '2022'}, { 'DOI': '10.1016/j.cdtm.2020.05.002', 'article-title': 'Pulmonary rehabilitation for patients with coronavirus disease 2019 ' '(COVID-19)', 'author': 'Yang', 'doi-asserted-by': 'publisher', 'first-page': '79', 'journal-title': 'Chronic Dis Transl Med', 'key': 'ref7', 'volume': '6', 'year': '2020'}, { 'DOI': '10.1016/j.jphys.2020.03.011', 'article-title': 'Physiotherapy management for COVID-19 in the acute hospital setting: ' 'clinical practice recommendations', 'author': 'Thomas', 'doi-asserted-by': 'publisher', 'first-page': '73', 'journal-title': 'J Physiother', 'key': 'ref8', 'volume': '66', 'year': '2020'}, { 'DOI': '10.4081/monaldi.2020.1285', 'article-title': 'Respiratory physiotherapy in patients with COVID-19 infection in acute ' 'setting: a position paper of 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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