Efficacy and Safety of Complementary Therapy With Jing Si Herbal Tea in Patients With Mild-To-Moderate COVID-19: A Prospective Cohort Study

DOI record: { "DOI": "10.3389/fnut.2022.832321", "ISSN": [ "2296-861X" ], "URL": "http://dx.doi.org/10.3389/fnut.2022.832321", "abstract": "<jats:sec><jats:title>Background</jats:title><jats:p>Since late 2019, there has been a global COVID-19 pandemic. To preserve medical capacity and decrease adverse health effects, preventing the progression of COVID-19 to severe status is essential. Jing-Si Herbal Tea (JSHT), a novel traditional Chinese medicine formula was developed to treat COVID-19. This study examined the clinical efficacy and safety of JSHT in patients with mild-to-moderate COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this prospective cohort study, we enrolled 260 patients with mild-to-moderate COVID-19. The enrolled patients were divided into the JSHT (<jats:italic>n</jats:italic> = 117) and control (<jats:italic>n</jats:italic> = 143) groups. Both groups received standard management. The JSHT group was treated with JSHT as a complementary therapy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Compared with standard management alone, JSHT combined with standard management more effectively improved the reverse transcription–polymerase chain reaction cycle threshold value, C-reactive protein level, and Brixia score in the adult patients with mild-to-moderate COVID-19, especially in the male and older patients (those aged ≥60 years). The results revealed that the patients treated with JSHT combined with standard management had 51, 70, and 100% lower risks of intubation, Medisave Care Unit admission, and mortality compared with those receiving standard management only.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>JSHT combined with standard management more effectively reduced the SARS-CoV-2 viral load and systemic inflammation and alleviated lung infiltrates in the patients with mild-to-moderate COVID-19, especially in the male and older patients (those aged ≥60 years). JSHT combined with standard management may prevent critical status and mortality in patients with mild-to-moderate COVID-19. JSHT is a promising complementary therapy for patients with mild-to-moderate COVID-19.</jats:p></jats:sec>", "alternative-id": [ "10.3389/fnut.2022.832321" ], "author": [ { "affiliation": [], "family": "Hsieh", "given": "Po-Chun", "sequence": "first" }, { "affiliation": [], "family": "Chao", "given": "You-Chen", "sequence": "additional" }, { "affiliation": [], "family": "Tsai", "given": "Kuo-Wang", "sequence": "additional" }, { "affiliation": [], "family": "Li", "given": "Chung-Hsien", "sequence": "additional" }, { "affiliation": [], "family": "Tzeng", "given": "I-Shiang", "sequence": "additional" }, { "affiliation": [], "family": "Wu", "given": "Yao-Kuang", "sequence": "additional" }, { "affiliation": [], "family": "Shih", "given": "Cheng Yen", "sequence": "additional" } ], "container-title": [ "Frontiers in Nutrition" ], "content-domain": { "crossmark-restriction": true, "domain": [ "frontiersin.org" ] }, "created": { "date-parts": [ [ 2022, 3, 14 ] ], "date-time": "2022-03-14T07:52:02Z", "timestamp": 1647244322000 }, "deposited": { "date-parts": [ [ 2022, 3, 14 ] ], "date-time": "2022-03-14T07:52:06Z", "timestamp": 1647244326000 }, "funder": [ { "DOI": "10.13039/501100008108", "doi-asserted-by": "publisher", "name": "Taipei Tzu Chi Hospital" } ], "indexed": { "date-parts": [ [ 2022, 3, 14 ] ], "date-time": "2022-03-14T08:12:31Z", "timestamp": 1647245551966 }, "is-referenced-by-count": 0, "issn-type": [ { "type": "electronic", "value": "2296-861X" } ], "issued": { "date-parts": [ [ 2022, 3, 14 ] ] }, "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 3, 14 ] ], "date-time": "2022-03-14T00:00:00Z", "timestamp": 1647216000000 } } ], "link": [ { "URL": "https://www.frontiersin.org/articles/10.3389/fnut.2022.832321/full", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "1965", 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Nutr." ], "short-title": [], "source": "Crossref", "subject": [ "Nutrition and Dietetics", "Endocrinology, Diabetes and Metabolism", "Food Science" ], "subtitle": [], "title": [ "Efficacy and Safety of Complementary Therapy With Jing Si Herbal Tea in Patients With Mild-To-Moderate COVID-19: A Prospective Cohort Study" ], "type": "journal-article", "update-policy": "http://dx.doi.org/10.3389/crossmark-policy", "volume": "9" }