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0 0.5 1 1.5 2+ Recovery time 48% Improvement Relative Risk Melatonin  Hosseini et al.  LATE TREATMENT Is late treatment with melatonin beneficial for COVID-19? Prospective study of 40 patients in Iran Faster recovery with melatonin (p=0.001) c19early.org Hosseini et al., European J. Pharmacol.., May 2021 Favors melatonin Favors control

Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment

Hosseini et al., European Journal of Pharmacology, doi:10.1016/j.ejphar.2021.174193
May 2021  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
40 hospitalized patients in Iran, 20 treated with melatonin, showing faster recovery and attenuated inflammatory cytokines with treatment.
recovery time, 47.6% lower, relative time 0.52, p = 0.001, treatment 20, control 20.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hosseini et al., 17 May 2021, prospective, Iran, peer-reviewed, 9 authors.
This PaperMelatoninAll
Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment
Abdolkarim Hosseini, Hadi Esmaeili Gouvarchin Ghaleh, Hossein Aghamollaei, Mahdi Fasihi Ramandi, Gholamhossein Alishiri, Alireza Shahriary, Kazem Hassanpour, Mahdi Tat, Gholamreza Farnoosh
European Journal of Pharmacology, doi:10.1016/j.ejphar.2021.174193
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Declaration of competing interest None to declare.
References
Acuña-Castroviejo, Escames, Figueira, De La Oliva, Borobia et al., Clinical trial to test the efficacy of melatonin in COVID-19, J. Pineal Res
Ahn, Shin, Kim, Lee, Kim et al., Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel coronavirus disease 2019 (COVID-19), J. Microbiol. Biotechnol
Akbari, Tabrizi, Lankarani, Aria, Vakili et al., The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis, Life Sci
Akbariqomi, Hosseini, Rashidiani, Sedighian, Biganeh et al., Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: a single-center, retrospective study in Iran, Diabetes Res. Clin. Pract
Alonso-González, Menéndez-Menéndez, González-González, González, Cos et al., Melatonin enhances the apoptotic effects and modulates the changes in gene expression induced by docetaxel in MCF-7 human breast cancer cells, Int. J. Oncol
Bahrampour, Juybari, Pourhanifeh, Hosseinzadeh, Hemati et al., Melatonin potentials against viral infections including COVID-19: current evidence and new findings, Virus Res
Bortolotti, Gentili, Rizzo, Rotola, Rizzo, SARS-CoV-2 spike 1 protein controls natural killer cell activation via the HLA-E/NKG2A pathway, Cells
Bouadma, Wiedemann, Patrier, Surénaud, Wicky et al., Immune alterations in a patient with SARS-CoV-2-related acute respiratory distress syndrome, J. Clin. Immunol
Burke, Young, IFN-γ: a cytokine at the right time, is in the right place, Semin. Immunol
Coutinho, Chapman, The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights, Mol. Cell. Endocrinol
Dittmer, Peterson, Messer, Stromnes, Race et al., Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccineprimed immune responses to Friend retrovirus infection, J. Virol
Farnoosh, Ghanei, Khorramdelazad, Alishiri, Jalali Farahani et al., Are Iranian sulfur mustard gas-exposed survivors more vulnerable to SARS-CoV-2? Some similarity in their pathogenesis, Disaster Med. Public Health Prep
Gadotti, De Castro Deus, Telles, Wind, Goes et al., IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection, Virus Res
Herrmann, Schulte, Wildner, Wittner, Brehm et al., Analysis of Coinhibitory receptor expression in COVID-19 infection compared to acute plasmodium falciparum malaria: LAG-3 and TIM-3 correlate with T cell activation and course of disease, Front. Immunol
Huang, Cao, Liu, Shi, Wei, Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice, J. Pineal Res
Ingawale, Mandlik, New insights into the novel anti-inflammatory mode of action of glucocorticoids, Immunopharmacol. Immunotoxicol
Kaneko, Kuo, Boucau, Farmer, Allard-Chamard et al., Loss of bcl-6-expressing T follicular helper cells and germinal centers in COVID-19, Cell
Laforge, Elbim, Frère, Hémadi, Massaad et al., Tissue damage from neutrophil-induced oxidative stress in COVID-19, Nat. Rev. Immunol
Leung, Liu, Fang, Chen, Guo et al., The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease, Cell. Mol. Immunol
Nair, Kandaswami, Mahajan, Chadha, Chawda et al., The flavonoid, quercetin, differentially regulates Th-1 (IFNgamma) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells, Biochim. Biophys. Acta
Nikpouraghdam, Jalali Farahani, Alishiri, Heydari, Ebrahimnia et al., Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in Iran: a single center study, J. Clin. Virol
Noble, Kemeny, Interleukin-4 enhances interferon-gamma synthesis but inhibits development of interferon-gamma-producing cells, Immunology
Pontes, Cardoso, Carneiro-Sampaio, Markus, Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production, J. Pineal Res
Reiter, Sharma, Ma, Dominquez-Rodriguez, Marik et al., Melatonin inhibits COVID-19-induced cytokine storm by reversing aerobic glycolysis in immune cells: a mechanistic analysis, Med Drug Discov
Rodríguez, Escames, López, López, García et al., Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice, J. Pineal Res
Shneider, Kudriavtsev, Vakhrusheva, Can melatonin reduce the severity of COVID-19 pandemic?, Int. Rev. Immunol
So, Park, Lee, IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4-induced IL-4 receptor gene expression, J. Immunol
Vaz De Paula, De Azevedo, Nagashima, Martins, Malaquias et al., IL-4/IL-13 remodeling pathway of COVID-19 lung injury, Sci. Rep
Zhang, Zhang, Gu, Sun, TH1/TH2 cell differentiation and molecular signals, Adv. Exp. Med. Biol
Late treatment
is less effective
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