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0 0.5 1 1.5 2+ Death/ICU -129% Improvement Relative Risk c19early.org/aa Holt et al. Spironolactone for COVID-19 Prophylaxis Favors spironolactone Favors control
Influence of inhibitors of the renin–angiotensin system on risk of acute respiratory distress syndrome in Danish hospitalized COVID-19 patients
Holt et al., Journal of Hypertension, doi:10.1097/hjh.0000000000002515
7 May 2020    Source   PDF   Share   Tweet
Retrospective 689 hospitalized COVID-19 patients in Denmark, showing higher risk of ICU/death with spironolactone use in unadjusted results subject to confounding by indication.
risk of death/ICU, 129.5% higher, RR 2.29, p < 0.001, treatment 16 of 31 (51.6%), control 148 of 658 (22.5%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
Holt et al., 7 May 2020, retrospective, Denmark, peer-reviewed, median age 70.0, 4 authors, study period 1 March, 2020 - 1 April, 2020.
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