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Home   COVID-19 treatment studies for Colchicine  COVID-19 treatment studies for Colchicine  C19 studies: Colchicine  Colchicine   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality -16% Improvement Relative Risk Mortality/therapeutic fail.. 42% c19early.org/o Hernández-Rodríguez et al. NCT04492358 FRAGILE-COLCOVID19 Colchicine RCT LATE Favors colchicine Favors dexamethasone
FRAGILE-COLCOVID19: A Clinical Trial Based on Early Administration of an Oral Combination of Colchicine and Prednisone in Elderly Patients with COVID-19 in Geriatric Facilities
Hernández-Rodríguez et al., Clinical Drug Investigation, doi:10.1007/s40261-022-01201-2, FRAGILE-COLCOVID19, NCT04492358 (history)
29 Sep 2022    Source   PDF   Share   Tweet
RCT 54 elderly patients in Spain comparing colchicine + prednisone vs. dexamethasone, showing lower combined mortality/therapeutic failure with colchicine + prednisone, but no significant difference in mortality. Data appears unreliable, for example authors report 5 deaths (20.97%) in the control arm, however 20.97% does not match the reported (or any) number of patients. Similarly for combined mortality/therapeutic failure where authors report 12 (45.13%) and 6 (28.13%).
risk of death, 16.0% higher, RR 1.16, p = 1.00, treatment 5 of 25 (20.0%), control 5 of 29 (17.2%).
mortality/therapeutic failure, 42.0% lower, RR 0.58, p = 0.25, treatment 6 of 25 (24.0%), control 12 of 29 (41.4%), NNT 5.8, combined mortality/therapeutic failure.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hernández-Rodríguez et al., 29 Sep 2022, Randomized Controlled Trial, Spain, peer-reviewed, 90 authors, study period March 2020 - October 2020, this trial compares with another treatment - results may be better when compared to placebo, this trial uses multiple treatments in the treatment arm (combined with prednisone) - results of individual treatments may vary, trial NCT04492358 (history) (FRAGILE-COLCOVID19).
Contact: jhernan@clinic.cat.
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Late treatment
is less effective
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