FRAGILE-COLCOVID19: A Clinical Trial Based on Early Administration of an Oral Combination of Colchicine and Prednisone in Elderly Patients with COVID-19 in Geriatric Facilities

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' '2020;9(9):2961.', 'journal-title': 'J Clin Med'}, { 'issue': '3', 'key': '1201_CR35', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0248276', 'volume': '16', 'author': 'L Manenti', 'year': '2021', 'unstructured': 'Manenti L, Maggiore U, Fiaccadori E, et al. Reduced mortality in ' 'COVID-19 patients treated with colchicine: results from a retrospective, ' 'observational study. PLoS ONE. 2021;16(3): e0248276.', 'journal-title': 'PLoS ONE'}, { 'issue': '1', 'key': '1201_CR36', 'doi-asserted-by': 'publisher', 'first-page': '57', 'DOI': '10.3855/jidc.14924', 'volume': '16', 'author': 'O Karakas', 'year': '2022', 'unstructured': 'Karakas O, Erden A, Guven SC, et al. Reducing length of hospital stay ' 'with colchicine. J Infect Dev Ctries. 2022;16(1):57–62.', 'journal-title': 'J Infect Dev Ctries'}, { 'key': '1201_CR37', 'doi-asserted-by': 'publisher', 'first-page': '8865954', 'DOI': '10.1155/2020/8865954', 'volume': '2020', 'author': 'T Sandhu', 'year': '2020', 'unstructured': 'Sandhu T, Tieng A, Chilimuri S, Franchin G. A case control study to ' 'evaluate the impact of colchicine on patients admitted to the hospital ' 'with moderate to severe COVID-19 infection. Can J Infect Dis Med ' 'Microbiol. 2020;2020:8865954.', 'journal-title': 'Can J Infect Dis Med Microbiol.'}, { 'issue': '10', 'key': '1201_CR38', 'doi-asserted-by': 'publisher', 'first-page': '1286', 'DOI': '10.1136/annrheumdis-2020-217712', 'volume': '79', 'author': 'M Scarsi', 'year': '2020', 'unstructured': 'Scarsi M, Piantoni S, Colombo E, et al. Association between treatment ' 'with colchicine and improved survival in a single-centre cohort of adult ' 'hospitalised patients with COVID-19 pneumonia and acute respiratory ' 'distress syndrome. Ann Rheum Dis. 2020;79(10):1286–9.', 'journal-title': 'Ann Rheum Dis'}, { 'issue': '1', 'key': '1201_CR39', 'doi-asserted-by': 'publisher', 'first-page': '66', 'DOI': '10.1186/s12941-021-00460-9', 'volume': '20', 'author': 'MA Pinzon', 'year': '2021', 'unstructured': 'Pinzon MA, Cardona Arango D, Betancur JF, et al. Clinical outcome of ' 'patients with COVID-19 Pneumonia treated with corticosteroids and ' 'colchicine in Colombia. Ann Clin Microbiol Antimicrob. 2021;20(1):66.', 'journal-title': 'Ann Clin Microbiol Antimicrob'}, { 'issue': '8', 'key': '1201_CR40', 'doi-asserted-by': 'publisher', 'first-page': '924', 'DOI': '10.1016/S2213-2600(21)00222-8', 'volume': '9', 'author': 'JC Tardif', 'year': '2021', 'unstructured': 'Tardif JC, Bouabdallaoui N, L’Allier PL, et al. Colchicine for ' 'community-treated patients with COVID-19 (COLCORONA): a phase 3, ' 'randomised, double-blinded, adaptive, placebo-controlled, multicentre ' 'trial. Lancet Respir Med. 2021;9(8):924–32.', 'journal-title': 'Lancet Respir Med'}, { 'issue': '6', 'key': '1201_CR41', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamanetworkopen.2020.13136', 'volume': '3', 'author': 'SG Deftereos', 'year': '2020', 'unstructured': 'Deftereos SG, Giannopoulos G, Vrachatis DA, et al. Effect of colchicine ' 'vs standard care on cardiac and inflammatory biomarkers and clinical ' 'outcomes in patients hospitalized with coronavirus disease 2019: the ' 'GRECCO-19 randomized clinical trial. JAMA Netw Open. 2020;3(6): ' 'e2013136.', 'journal-title': 'JAMA Netw Open'}, { 'issue': '1', 'key': '1201_CR42', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/rmdopen-2020-001455', 'volume': '7', 'author': 'MI Lopes', 'year': '2021', 'unstructured': 'Lopes MI, Bonjorno LP, Giannini MC, et al. Beneficial effects of ' 'colchicine for moderate to severe COVID-19: a randomised, ' 'double-blinded, placebo-controlled clinical trial. RMD Open. 2021;7(1): ' 'e001455.', 'journal-title': 'RMD Open'}, { 'key': '1201_CR43', 'doi-asserted-by': 'publisher', 'first-page': '5517', 'DOI': '10.2147/IJGM.S329810', 'volume': '14', 'author': 'DA Pascual-Figal', 'year': '2021', 'unstructured': 'Pascual-Figal DA, Roura-Piloto AE, Moral-Escudero E, et al. Colchicine ' 'in recently hospitalized patients with COVID-19: a randomized controlled ' 'trial (COL-COVID). Int J Gen Med. 2021;14:5517–26.', 'journal-title': 'Int J Gen Med.'}, { 'key': '1201_CR44', 'doi-asserted-by': 'publisher', 'first-page': '2129006', 'DOI': '10.1155/2021/2129006', 'volume': '2021', 'author': 'M Alsultan', 'year': '2021', 'unstructured': 'Alsultan M, Obeid A, Alsamarrai O, et al. Efficacy of colchicine and ' 'budesonide in improvement outcomes of patients with coronavirus ' 'infection 2019 in Damascus, Syria: a randomized control trial. ' 'Interdiscip Perspect Infect Dis. 2021;2021:2129006.', 'journal-title': 'Interdiscip Perspect Infect Dis.'}, { 'issue': '2', 'key': '1201_CR45', 'doi-asserted-by': 'publisher', 'first-page': '15', 'DOI': '10.18087/cardio.2021.2.n1560', 'volume': '61', 'author': 'VY Mareev', 'year': '2021', 'unstructured': 'Mareev VY, Orlova YA, Plisyk AG, et al. Proactive anti-inflammatory ' 'therapy with colchicine in the treatment of advanced stages of new ' 'coronavirus infection. The first results of the COLORIT study. ' 'Kardiologiia. 2021;61(2):15–27.', 'journal-title': 'Kardiologiia'}, { 'issue': '2', 'key': '1201_CR46', 'doi-asserted-by': 'publisher', 'first-page': '891', 'DOI': '10.1002/ptr.7319', 'volume': '36', 'author': 'G Pourdowlat', 'year': '2022', 'unstructured': 'Pourdowlat G, Saghafi F, Mozafari A, et al. Efficacy and safety of ' 'colchicine treatment in patients with COVID-19: a prospective, ' 'multicenter, randomized clinical trial. Phytother Res. 2022;36(2):891–8.', 'journal-title': 'Phytother Res'}, { 'issue': '720', 'key': '1201_CR47', 'doi-asserted-by': 'publisher', 'first-page': 'e446', 'DOI': '10.3399/BJGP.2022.0083', 'volume': '72', 'author': 'J Dorward', 'year': '2022', 'unstructured': 'Dorward J, Yu LM, Hayward G, et al. Colchicine for COVID-19 in adults in ' 'the community (PRINCIPLE): a randomised, controlled, adaptive platform ' 'trial. Br J Gen Pract. 2022;72(720):e446–55.', 'journal-title': 'Br J Gen Pract'}, { 'issue': '12', 'key': '1201_CR48', 'doi-asserted-by': 'publisher', 'first-page': '1419', 'DOI': '10.1016/S2213-2600(21)00435-5', 'volume': '9', 'author': 'Recovery Collaborative Group', 'year': '2021', 'unstructured': 'Recovery Collaborative Group. Colchicine in patients admitted to ' 'hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, ' 'platform trial. Lancet Respir Med. 2021;9(12):1419–26.', 'journal-title': 'Lancet Respir Med'}, { 'issue': '12', 'key': '1201_CR49', 'doi-asserted-by': 'publisher', 'DOI': '10.1001/jamanetworkopen.2021.41328', 'volume': '4', 'author': 'R Diaz', 'year': '2021', 'unstructured': 'Diaz R, Orlandini A, Castellana N, et al. Effect of colchicine vs usual ' 'care alone on intubation and 28-day mortality in patients hospitalized ' 'with COVID-19: a randomized clinical trial. JAMA Netw Open. 2021;4(12): ' 'e2141328.', 'journal-title': 'JAMA Netw Open'}, { 'issue': '1', 'key': '1201_CR50', 'doi-asserted-by': 'publisher', 'first-page': '4', 'DOI': '10.1007/s11606-021-07203-8', 'volume': '37', 'author': 'A Absalon-Aguilar', 'year': '2022', 'unstructured': 'Absalon-Aguilar A, Rull-Gabayet M, Perez-Fragoso A, et al. Colchicine is ' 'safe though ineffective in the treatment of severe COVID-19: a ' 'randomized clinical trial (COLCHIVID). J Gen Intern Med. ' '2022;37(1):4–14.', 'journal-title': 'J Gen Intern Med'}, { 'key': '1201_CR51', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.eclinm.2021.101242', 'volume': '43', 'author': 'HG Gaitan-Duarte', 'year': '2022', 'unstructured': 'Gaitan-Duarte HG, Alvarez-Moreno C, Rincon-Rodriguez CJ, et al. ' 'Effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir ' 'and combinations thereof in hospitalized patients with COVID-19: a ' 'pragmatic, open-label randomized trial. EClinicalMedicine. 2022;43: ' '101242.', 'journal-title': 'EClinicalMedicine.'}, { 'key': '1201_CR52', 'first-page': 'CD015045', 'volume': '10', 'author': 'A Mikolajewska', 'year': '2021', 'unstructured': 'Mikolajewska A, Fischer AL, Piechotta V, et al. Colchicine for the ' 'treatment of COVID-19. 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Immun ' 'Inflamm Dis. 2022;10(2):255–64.', 'journal-title': 'Immun Inflamm Dis.'}, { 'key': '1201_CR59', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.intimp.2021.107723', 'volume': '96', 'author': 'EN Nawangsih', 'year': '2021', 'unstructured': 'Nawangsih EN, Kusmala YY, Rakhmat II, et al. Colchicine and mortality in ' 'patients with coronavirus disease 2019 (COVID-19) pneumonia: a ' 'systematic review, meta-analysis, and meta-regression. Int ' 'Immunopharmacol. 2021;96: 107723.', 'journal-title': 'Int Immunopharmacol'}, { 'key': '1201_CR60', 'doi-asserted-by': 'publisher', 'first-page': '205873842110317', 'DOI': '10.1177/20587384211031763', 'volume': '35', 'author': 'M Golpour', 'year': '2021', 'unstructured': 'Golpour M, Mousavi T, Alimohammadi M, et al. The effectiveness of ' 'colchicine as an anti-inflammatory drug in the treatment of coronavirus ' 'disease 2019: meta-analysis. Int J Immunopathol Pharmacol. ' '2021;35:20587384211031764.', 'journal-title': 'Int J Immunopathol Pharmacol'}, { 'issue': '2', 'key': '1201_CR61', 'doi-asserted-by': 'publisher', 'first-page': '379', 'DOI': '10.1007/s40744-022-00425-0', 'volume': '9', 'author': 'AA Drosos', 'year': '2022', 'unstructured': 'Drosos AA, Pelechas E, Drossou V, Voulgari PV. Colchicine against ' 'SARS-CoV-2 infection: what is the evidence? Rheumatol Ther. ' '2022;9(2):379–89.', 'journal-title': 'Rheumatol Ther.'}, { 'issue': '9', 'key': '1201_CR62', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/eci.13645', 'volume': '51', 'author': 'MN Elshafei', 'year': '2021', 'unstructured': 'Elshafei MN, El-Bardissy A, Khalil A, et al. Colchicine use might be ' 'associated with lower mortality in COVID-19 patients: a meta-analysis. ' 'Eur J Clin Invest. 2021;51(9): e13645.', 'journal-title': 'Eur J Clin Invest'}, { 'issue': '6', 'key': '1201_CR63', 'doi-asserted-by': 'publisher', 'first-page': '823', 'DOI': '10.1111/1440-1681.13488', 'volume': '48', 'author': 'TI Hariyanto', 'year': '2021', 'unstructured': 'Hariyanto TI, Halim DA, Jodhinata C, Yanto TA, Kurniawan A. Colchicine ' 'treatment can improve outcomes of coronavirus disease 2019 (COVID-19): a ' 'systematic review and meta-analysis. Clin Exp Pharmacol Physiol. ' '2021;48(6):823–30.', 'journal-title': 'Clin Exp Pharmacol Physiol'}, { 'issue': '12', 'key': '1201_CR64', 'doi-asserted-by': 'publisher', 'DOI': '10.1371/journal.pone.0261358', 'volume': '16', 'author': 'L Chiu', 'year': '2021', 'unstructured': 'Chiu L, Lo CH, Shen M, et al. Colchicine use in patients with COVID-19: ' 'a systematic review and meta-analysis. 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SEID S.A. (Lliçà ' 'de Vall, Barcelona, Spain) also provided the Colchicina SEID^® ' 'tablets used in the study. None of the sponsors had any role in the study ' 'design or development, data analysis, or manuscript writing.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Funding'}}, { 'value': 'José Hernández-Rodríguez, Julio Durán-Sanclemente, Sergio Prieto-González, Olga ' 'Araújo, Teresa Hospital-Vidal, Georgina Casanovas, Víctor Sapena, José Luis ' 'Blanco, and Alfonso López-Soto declare no conflicts of interest in this work.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Conflict of interest'}}, { 'value': 'This study was approved by the Clinical Research Ethics Committee at the ' 'Hospital Clínic of Barcelona (EudraCT Number 2020-002462-14).', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval'}}, { 'value': 'All patients or legally authorized representatives signed the informed consent ' 'form.', 'order': 5, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent to participate'}}, { 'value': 'Not applicable.', 'order': 6, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The data generated during the current study are available from the ' 'corresponding author on reasonable request.', 'order': 7, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Availability of data and material'}}, { 'value': 'Not applicable.', 'order': 8, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Code availability'}}, { 'value': 'JHR and JLB were involved in the conceptualization and design of the study ' 'protocol. ALS and JDS allowed the launch of the study by providing the ' 'geriatric facilities and encouraging the participation of their healthcare ' 'personnel. JDS, SPG, OA, THV, and all Members of the FRAGILE-COLCOVID19 Study ' 'Group recruited patients, collected data, and/or monitored patients enrolled in ' 'the study. VS and GC performed the statistical analysis and summarized the ' 'statistical data for the manuscript. JHR was responsible for funding ' 'acquisition, project administration and data analysis, and wrote the ' 'manuscript. All authors contributed to the critical revision and editing of the ' 'manuscript and approved its final version.', 'order': 9, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Author contributions'}}]}