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Beneficial role of healthy eating Index-2015 score & physical activity on COVID-19 outcomes

Hegazy et al., BMC Nutrition, doi:10.1186/s40795-023-00727-8, NCT04447144
Oct 2023  
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Moderate case 64% Improvement Relative Risk Diet for COVID-19  Hegazy et al.  Prophylaxis Is a healthy diet beneficial for COVID-19? Retrospective study in Egypt (May 2021 - February 2022) Fewer moderate/severe cases with healthier diets (p=0.0047) c19early.org Hegazy et al., BMC Nutrition, October 2023 Favorshealthy diet Favorscontrol 0 0.5 1 1.5 2+
Diet for COVID-19
22nd treatment shown to reduce risk in June 2021
 
*, now with p < 0.00000000001 from 28 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 68 COVID-19 patients showing higher healthy eating index scores associated with lower risk of moderate vs. mild COVID-19.
Study covers diet and exercise.
risk of moderate case, 64.0% lower, OR 0.36, p = 0.005, adjusted per study, for HEI as a continuous value, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Hegazy et al., 2 Oct 2023, retrospective, Egypt, peer-reviewed, 7 authors, study period May 2021 - February 2022, trial NCT04447144 (history). Contact: monahegazy@cu.edu.eg.
This PaperDietAll
Beneficial role of healthy eating Index-2015 score & physical activity on COVID-19 outcomes
Mona A Hegazy, Marwa M Fouad, Samah Ahmed Abd Elshafy, Dalia Abdelfatah, Rania M Lithy, Ahmed Abdelghani, Omar Ahmed Ashoush
BMC Nutrition, doi:10.1186/s40795-023-00727-8
Background Nutritional status and physical activity are essential to maintain a strong immune system. No definite pharmacological strategies for Coronavirus disease 2019 treatment are presently available, so natural enhancement of the immune system is in need. Our goal was to assess the correlation of healthy diet and physical activity on COVID-19 disease outcome. Methods This cohort study was conducted on 68 adult patients who contracted mild (38) or moderate [30] cases of COVID-19, recruited via a convenience sampling technique from the outpatient clinic, Kasr Al-Aini Faculty of Medicine, Cairo University Hospital. Patients' Healthy Eating Index (HEI) and degree of physical activity as measured by the Global Physical Activity Questionnaire were evaluated and linked with several inflammatory markers. Results Most of patients with mild COVID-19 patients (92.1%) were physically active, compared to only 50% of moderate COVID-19. The total Metabolic Equivalent Task-min/week was positively correlated with the lymphocyte percentage. The median total HEI score was significantly higher in the patients with mild COVID-19 than with moderate COVID. Significant positive correlations observed among the lymphocyte count and total HEI-2015. There was approximately a 64% reduction in the probability of acquiring moderate COVID-19 illness for each unit rise in The HEI. Conclusion Healthier nutrition and Physical activity correlated with reduced COVID-19 disease severity.
Authors' contributions All authors contributed to the study's conception and design. Material preparation, data collection, and analysis were performed by [MH, MF, SA, RL, DA, AA, OA]. The first draft of the manuscript was written by [MH, MF] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. Declarations Ethics approval and consent to participate The study was approved by Research Ethics Committee, Faculty of Medicine, Cairo University (REC n-86-2020). Informed consent Informed consent was obtained from all subjects. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication Not applicable. Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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' '2018;13:e0194991.', 'journal-title': 'PLoS ONE'}], 'container-title': 'BMC Nutrition', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s40795-023-00727-8.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s40795-023-00727-8/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s40795-023-00727-8.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 10, 2]], 'date-time': '2023-10-02T15:07:02Z', 'timestamp': 1696259222000}, 'score': 1, 'resource': {'primary': {'URL': 'https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-023-00727-8'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 10, 2]]}, 'references-count': 35, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2023, 12]]}}, 'alternative-id': ['727'], 'URL': 'http://dx.doi.org/10.1186/s40795-023-00727-8', 'relation': {}, 'ISSN': ['2055-0928'], 'subject': [ 'Public Health, Environmental and Occupational Health', 'Nutrition and Dietetics', 'Endocrinology, Diabetes and Metabolism', 'Medicine (miscellaneous)'], 'container-title-short': 'BMC Nutr', 'published': {'date-parts': [[2023, 10, 2]]}, 'assertion': [ { 'value': '19 October 2022', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '14 June 2023', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '2 October 2023', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'The study was approved by Research Ethics Committee, Faculty of Medicine, Cairo ' 'University (REC n-86-2020).', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'Informed consent was obtained from all subjects. All methods were carried out ' 'in accordance with relevant guidelines and regulations.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Informed consent'}}, { 'value': 'Not applicable.', 'order': 4, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Consent for publication'}}, { 'value': 'The authors declare no competing interests.', 'order': 5, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '113'}
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