Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19

DOI record: { "DOI": "10.1038/s41375-021-01299-x", "ISSN": [ "0887-6924", "1476-5551" ], "URL": "http://dx.doi.org/10.1038/s41375-021-01299-x", "alternative-id": [ "1299" ], "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "1 April 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "12 May 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "24 May 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Change Date", "name": "change_date", "order": 4, "value": "28 June 2021" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Change Type", "name": "change_type", "order": 5, "value": "Correction" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Change Details", "name": "change_details", "order": 6, "value": "A Correction to this paper has been published:" }, { "URL": "https://doi.org/10.1038/s41375-021-01329-8", "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Change Details", "name": "change_details", "order": 7, "value": "https://doi.org/10.1038/s41375-021-01329-8" }, { "group": { "label": "Compliance with ethical standards", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Conflict of interest", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "JPM, BMJO, and KJKK are employees of EUSA Pharma. AR reports consultancy fees from Amgen, Celgene, Gilead, Italfarmaco, Novartis, Omeros, Pfizer, and Roche; travel support from Amgen, Celgene, Gilead, Italfarmaco, Novartis, and Roche; and research grants from Amgen, Italfarmaco, and Roche. CM reports travel support from Medac. DR reports personal fees from Gilead, Janssen, and ViiV. FDM reports grants from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, and Novartis; and personal fees from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Guidotti/Malesci, Menarini, Mundipharma, Novartis, Teva, and Zambon. GG reports non-financial support from Gilead Kite, Janssen, Roche, and Takeda; and personal fees from Amgen, Autolus, Gilead Kite, Italfarmaco, IQVIA, Roche, and Takeda. IR reports travel support from Aferetica. SF reports grants from Gilead and Novartis; and personal fees from AbbVie, Astellas, Bayer, Gilead, Intercept, Kedrion, Merck Sharp & Dohme, and Novartis. BB and AM are inventors of patents on PTX3 and obtain royalties on related reagents. The other authors declare no competing interests." }, { "group": { "label": "Ethics approval and consent to participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "We complied with all relevant ethical rules. The protocol and informed consent forms were approved by the Hospital Ethics Board at the Papa Giovanni XXIII Hospital in Bergamo, Italy. 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