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A higher frequency of physical activity is associated with reduced rates of SARS-CoV-2 infection

Green et al., European Journal of General Practice, doi:10.1080/13814788.2022.2138855
Nov 2022  
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Case 42% Improvement Relative Risk Exercise for COVID-19  Green et al.  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 113,075 patients in Israel (February - December 2020) Fewer cases with higher activity levels (p<0.000001) c19early.org Green et al., European J. General Prac.., Nov 2022 Favorsexercise Favorsinactivity 0 0.5 1 1.5 2+
Exercise for COVID-19
9th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 68 studies.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 112 treatments. c19early.org
Retrospective 113,075 people in Israel, showing lower risk of COVID-19 cases with physical activity and a dose dependent response.
Study covers vitamin D and exercise.
risk of case, 41.7% lower, RR 0.58, p < 0.001, high activity levels 1,267 of 11,144 (11.4%), low activity levels 16,198 of 101,931 (15.9%), adjusted per study, odds ratio converted to relative risk, >3 times per week vs. none, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Green et al., 7 Nov 2022, retrospective, Israel, peer-reviewed, 9 authors, study period 1 February, 2020 - 31 December, 2020.
This PaperExerciseAll
A higher frequency of physical activity is associated with reduced rates of SARS-CoV-2 infection
Ilan Green, Eugene Merzon, Shlomo Vinker, Avivit Golan-Cohen, Ariel Israel, Mickey Scheinowitz, Reuven Ishai, Shai Ashkenazi, Eli Magen
European Journal of General Practice, doi:10.1080/13814788.2022.2138855
Individuals who engage with PA were less susceptible to SARS-CoV-2 infection. As the frequency of PA increased, the risk of being SARS-CoV-2-positive decreased. PA may have a possible protective effect against viral infections.
References
Caputo, Reichert, Studies of physical activity and COVID-19 during the pandemic: a scoping review, J Phys Act Health
Da Silveira, Da, Fagundes, Bizuti, Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature, Clin Exp Med
Damiot, Pinto, Turner, Immunological implications of physical inactivity among older adults during the COVID-19 pandemic, Gerontology
Das, Graham, Cardozo, Myokines in skeletal muscle physiology and metabolism: recent advances and future perspectives, Acta Physiol (Oxf)
Duggal, Niemiro, Harridge, Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?, Nat Rev Immunol
Duggal, Pollock, Lazarus, Major features of immune senescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood, Aging Cell
El Hangouche, Amekran, Immune response to physical exercise: evidence to take into account during the coronavirus disease (COVID-19) pandemic, J Sports Med Phys Fitness
Friedman, Leventer-Roberts, Rosenblum, Development and validation of novel algorithms to identify patients with inflammatory bowel diseases in Israel: an epi-IIRN group study, Clin Epidemiol
Gandhi, Lynch, Rio, Mild or moderate Covid-19, N Engl J Med
Gonzalez-Gil, Elizondo-Montemayor, The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and fat mass loss: a review, Nutrients
Graff, Kunz, Agha, b 2 -Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8þ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans, Brain Behav Immun
Green, Merzon, Vinker, COVID-19 susceptibility in bronchial asthma, J Allergy Clin Immunol Pract
Kohut, Arntson, Lee, Moderate exercise improves antibody response to influenza immunization in older adults, Vaccine
Kunz, Spielmann, Agha, A single exercise bout augments adenovirus-specific T-cell mobilization and function, Physiol Behav
Laddu, Lavie, Phillips, Physical activity for immunity protection: Inoculating populations with healthy living medicine in preparation for the next pandemic, Prog Cardiovasc Dis
Matthews, Ockene, Freedson, Moderate to vigorous physical activity and risk of upper-respiratory tract infection, Med Sci Sports Exerc
Merzon, Green, Shpigelman, Haemoglobin A1c is a predictor of COVID-19 severity in patients with diabetes, Diabetes Metab Res Rev
Merzon, Green, Vinker, The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID-19 infection, FEBS J
Merzon, Manor, Rotem, ), Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases, J Atten Disord
Merzon, Tworowski, Gorohovski, Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study, FEBS J
Myers, Kokkinos, Arena, The impact of moving more, physical activity, and cardiorespiratory fitness: why we should strive to measure and improve fitness, Prog Cardiovasc Dis
Nieman, Henson, Austin, Upper respiratory tract infection is reduced in physically fit and active adults, Br J Sports Med
Pape, Ryttergaard, Rotevatn, Leisure-time physical activity and the risk of suspected bacterial infections, Med Sci Sports Exerc
Piercy, Troiano, Physical activity guidelines for Americans from the US Department of Health and Human Services, Circ Cardiovasc Qual Outcomes
Powell, King, Buchner, The scientific foundation for the physical activity guidelines for Americans, 2nd edition, J Phys Act Health
Prince, Adamo, Hamel, A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review, Int J Behav Nutr Phys Act
Rennert, Peterburg, Prevalence of selected chronic diseases in Israel, Isr Med Assoc J
Sallis, Pratt, A call to action: physical activity and COVID-19
Shalev, Chodick, Goren, The use of an automated patient registry to manage and monitor cardiovascular conditions and related outcomes in a large health organization, Int J Cardiol
Shephard, Limits to the measurement of habitual physical activity by questionnaires, Br J Sports Med
Trost, Owen, Bauman, Correlates of adults' participation in physical activity: review and update, Med Sci Sports Exerc
Zbinden-Foncea, Francaux, Deldicque, Does high cardiorespiratory fitness confer some protection against proinflammatory responses after infection by SARS-CoV-2? Obesity (Silver Spring)
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