Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study

{ 'indexed': {'date-parts': [[2024, 3, 21]], 'date-time': '2024-03-21T01:08:07Z', 'timestamp': 1710983287602}, 'reference-count': 40, 'publisher': 'Springer Science and Business Media LLC', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2024, 3, 20]], 'date-time': '2024-03-20T00:00:00Z', 'timestamp': 1710892800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}, { 'start': { 'date-parts': [[2024, 3, 20]], 'date-time': '2024-03-20T00:00:00Z', 'timestamp': 1710892800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>This retrospective study aimed to compare the ' 'mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), ' 'non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients ' 'admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were ' 'included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal ' 'influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities ' 'than the other patients. At admission, patients in the COVID-19 group were significantly less ' 'severe than the others according to the simplified acute physiology score-2 (SAPS-II) and ' 'sepsis-related organ failure assessment (SOFA) scores. Using competing risk regression, ' 'COVID-19 (sHR\u2009=\u20091.61; 95% CI 1.10; 2.36) and H1N1 (sHR\u2009=\u20091.87; 95% CI ' '1.20; 2.93) were associated with a statistically significant higher mortality while seasonal ' 'influenza was not (sHR\u2009=\u20090.93; 95% CI 0.65; 1.31), when compared to RSV. Despite ' 'occurring in more severe patients, RSV and seasonal influenza group appear to be associated ' 'with a more favorable outcome than COVID-19 and H1N1 groups.</jats:p>', 'DOI': '10.1038/s41598-024-55378-x', 'type': 'journal-article', 'created': {'date-parts': [[2024, 3, 20]], 'date-time': '2024-03-20T10:02:04Z', 'timestamp': 1710928924000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a ' 'multicenter retrospective study', 'prefix': '10.1038', 'volume': '14', 'author': [ {'given': 'Baptiste', 'family': 'Grangier', 'sequence': 'first', 'affiliation': []}, {'given': 'Charles-Hervé', 'family': 'Vacheron', 'sequence': 'additional', 'affiliation': []}, {'given': 'Donatien', 'family': 'De Marignan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean-Sebastien', 'family': 'Casalegno', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sandrine', 'family': 'Couray-Targe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Audrey', 'family': 'Bestion', 'sequence': 'additional', 'affiliation': []}, {'given': 'Florence', 'family': 'Ader', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean-Christophe', 'family': 'Richard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emilie', 'family': 'Frobert', 'sequence': 'additional', 'affiliation': []}, {'given': 'Laurent', 'family': 'Argaud', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thomas', 'family': 'Rimmele', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne-Claire', 'family': 'Lukaszewicz', 'sequence': 'additional', 'affiliation': []}, {'given': 'Frédéric', 'family': 'Aubrun', 'sequence': 'additional', 'affiliation': []}, {'given': 'Frédéric', 'family': 'Dailler', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean-Luc', 'family': 'Fellahi', 'sequence': 'additional', 'affiliation': []}, {'given': 'Julien', 'family': 'Bohe', 'sequence': 'additional', 'affiliation': []}, {'given': 'Vincent', 'family': 'Piriou', 'sequence': 'additional', 'affiliation': []}, {'given': 'Bernard', 'family': 'Allaouchiche', 'sequence': 'additional', 'affiliation': []}, {'given': 'Arnaud', 'family': 'Friggeri', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3174-6246', 'authenticated-orcid': False, 'given': 'Florent', 'family': 'Wallet', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fabrice', 'family': 'Thiolliere', 'sequence': 'additional', 'affiliation': []}, {'given': 'Emilie', 'family': 'Joffredo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Lucille', 'family': 'Jay', 'sequence': 'additional', 'affiliation': []}, {'given': 'Marie', 'family': 'Darien', 'sequence': 'additional', 'affiliation': []}, {'given': 'Jean-Stéphane', 'family': 'David', 'sequence': 'additional', 'affiliation': []}, {'given': 'Charlotte', 'family': 'Cerruti', 'sequence': 'additional', 'affiliation': []}, {'given': 'Maxime', 'family': 'Lecocq', 'sequence': 'additional', 'affiliation': []}, {'given': 'Guillaume', 'family': 'Izaute', 'sequence': 'additional', 'affiliation': []}, {'given': 'Thomas', 'family': 'Collenot', 'sequence': 'additional', 'affiliation': []}, {'given': 'Olivia', 'family': 'Vassal', 'sequence': 'additional', 'affiliation': []}, {'name': 'The Lyon Sud COVID-19 ICU', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 3, 20]]}, 'reference': [ { 'key': '55378_CR1', 'doi-asserted-by': 'publisher', 'first-page': '544', 'DOI': '10.3181/00379727-92-22538', 'volume': '92', 'author': 'RE Blount', 'year': '1956', 'unstructured': 'Blount, R. E., Morris, J. A. & Savage, R. E. Recovery of cytopathogenic ' 'agent from chimpanzees with coryza. Proc. Soc. Exp. Biol. Med. Soc. Exp. ' 'Biol. Med. N. Y. N 92, 544–549 (1956).', 'journal-title': 'Proc. Soc. Exp. Biol. Med. Soc. Exp. Biol. Med. N. Y. N'}, { 'key': '55378_CR2', 'doi-asserted-by': 'publisher', 'first-page': '2047', 'DOI': '10.1016/S0140-6736(22)00478-0', 'volume': '399', 'author': 'Y Li', 'year': '2022', 'unstructured': 'Li, Y. et al. Global, regional, and national disease burden estimates of ' 'acute lower respiratory infections due to respiratory syncytial virus in ' 'children younger than 5 years in 2019: A systematic analysis. Lancet ' 'Lond. Engl. 399, 2047–2064 (2022).', 'journal-title': 'Lancet Lond. Engl.'}, { 'key': '55378_CR3', 'doi-asserted-by': 'publisher', 'first-page': '1545', 'DOI': '10.1016/S0140-6736(10)60206-1', 'volume': '375', 'author': 'H Nair', 'year': '2010', 'unstructured': 'Nair, H. et al. 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Assessing the clinical severity of the Omicron variant ' 'in the Western Cape Province, South Africa, using the diagnostic PCR ' 'proxy marker of RdRp target delay to distinguish between Omicron and ' 'Delta infections—A survival analysis. Int. J. Infect. Dis. 118, 150–154 ' '(2022).', 'journal-title': 'Int. J. Infect. Dis.'}, { 'key': '55378_CR30', 'doi-asserted-by': 'publisher', 'first-page': '47', 'DOI': '10.1007/s40121-020-00383-6', 'volume': '10', 'author': 'JB Domachowske', 'year': '2021', 'unstructured': 'Domachowske, J. B., Anderson, E. J. & Goldstein, M. The future of ' 'respiratory syncytial virus disease prevention and treatment. Infect. ' 'Dis. Ther. 10, 47–60 (2021).', 'journal-title': 'Infect. Dis. Ther.'}, { 'key': '55378_CR31', 'doi-asserted-by': 'publisher', 'first-page': '711', 'DOI': '10.1056/NEJMoa1401184', 'volume': '371', 'author': 'JP DeVincenzo', 'year': '2014', 'unstructured': 'DeVincenzo, J. P. et al. 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