INTRAHOSPITAL SUPERVISED EXERCISE TRAINING IMPROVES SURVIVAL RATE AMONG HYPERTENSIVE COVID-19 PATIENTS
Francisco Fernandez, Manuel Vazquez-Muñoz, Andrea Canals, Alexis Arce-Álvarez, Camila Salazar-Ardiles, Cristian Alvarez, Rodrigo Ramirez- Campillo, Gregoire P Millet, Mikel Izquierdo, Ph.D David C Andrade, Andres Bello, Santiago
New & Noteworthy In the present study, we found that exercise training improves the survival rate in hypertensive COVID-19 patients during their hospitalization period. Our results provide strong evidence for the therapeutic efficacy of exercise training as a feasible approach to improving the outcomes of COVID-19 patients who suffer from hypertension during their hospitalization.
CONFLICT OF INTEREST None.
AUTHOR CONTRIBUTION F.F., and M.V-M., contributed to the draft and preparation of the manuscript. F.F., M.V-M., and A.C., contributed to the analysis of the data. A.A.A., C.S-A., C.A., R-R-C., G.P-M., and M.I., contributed to the preparation of the manuscript. D.C.A. contributed to the concept of the project. D.C.A. contributed to the preparation of the manuscript. All authors approved the final version of the manuscript.
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"abstract": "<jats:p> Among the people most affected by coronavirus disease 2019 (COVID-19) are those suffering from hypertension (HTN). However, pharmacological therapies for HTN are ineffective against COVID-19 progression and severity. It has been proposed that exercise training (EX) could be used as post-COVID treatment, which does not rule out the possible effects during hospitalization for COVID-19. Therefore, we aimed to determine the impact of supervised EX on HTN patients with COVID-19 during hospitalization. Among a total of 1,508 hospitalized COVID-19 patients (confirmed by PCR), 439 subjects were classified as having HTN and were divided into two groups: EX (n=201) and control (n=238) groups. EX (3 to 4 times per week during all hospitalizations) consisted of aerobic exercises (15 to 45 min) (i.e., walking); breathing exercises (10 to 15 min) (i.e., diaphragmatic breathing, pursed-lip breathing, active abdominal contraction); and musculoskeletal exercises (8-10 sets of 12-15 repetitions/week) (lifting dumbbells, standing up and sitting, lumbar stabilization). Our data revealed that the EX (clinician: patient, 1:1 ratio) intervention was able to improve survival rates among controlled HTN patients with COVID-19 during their hospitalization when compared to the control group (chi-squared: 4.83; hazard ratio: 1.8; 95% CI: 1.117 to 2.899; p=0.027). Multivariate logistic regression analysis revealed that EX was a prognostic marker (odds ratio: 0.449; 95% CI: 0.230 to 0.874; p=0.018) along with sex and invasive and non-invasive mechanical ventilation. Our data showed that an intrahospital supervised EX program reduced the mortality rate among HTN patients suffering from COVID-19 during their hospitalization. </jats:p>",
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