Conv. Plasma
Nigella Sativa

All nigella sativa studies
Meta analysis
study COVID-19 treatment researchNigella SativaNigella Sativa (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 6% Improvement Relative Risk Ventilation, day 14 62% Ventilation, day 7 83% ICU stay, >28 days 23% ICU stay, >21 days 28% ICU stay, >14 days 34% ICU stay, >7 days 7% Nigella Sativa  Faruq et al.  ICU PATIENTS  RCT Is very late treatment with nigella sativa beneficial for COVID-19? RCT 150 patients in Bangladesh Lower ventilation with nigella sativa (p=0.012) Faruq et al., Bangladesh Critical Care.., Sep 2023 Favors nigella sativa Favors control

Role of Nigella Sativa (black cumin seeds)as an adjunct therapy in treating severe and critical COVID -19 infection compared to those with standard therapy : An open label randomized clinical trial

Faruq et al., Bangladesh Critical Care Journal, doi:10.3329/bccj.v11i2.69187
Sep 2023  
  Source   PDF   All   Meta
11th treatment shown to reduce risk in January 2021
*, now known with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Open label randomized trial of 150 ICU patients in Bangladesh, showing shorter ICU stay and lower requirements for increased oxygen support including mechanical ventilation with nigella sativa treatment, but no significant difference in mortality.
The large baseline difference in convalescent plasma usage suggests an error or randomization problem.
This study is excluded in the after exclusion results of meta analysis: potential data issue.
risk of death, 6.5% lower, RR 0.94, p = 0.87, treatment 29 of 75 (38.7%), control 31 of 75 (41.3%), NNT 37.
risk of mechanical ventilation, 61.9% lower, RR 0.38, p = 0.01, treatment 8 of 75 (10.7%), control 21 of 75 (28.0%), NNT 5.8, day 14.
risk of mechanical ventilation, 83.3% lower, RR 0.17, p < 0.001, treatment 3 of 75 (4.0%), control 18 of 75 (24.0%), NNT 5.0, day 7.
ICU stay, 23.5% lower, RR 0.77, p = 0.74, treatment 4 of 46 (8.7%), control 5 of 44 (11.4%), NNT 37, >28 days.
ICU stay, 28.3% lower, RR 0.72, p = 0.46, treatment 9 of 46 (19.6%), control 12 of 44 (27.3%), NNT 13, >21 days.
ICU stay, 33.6% lower, RR 0.66, p = 0.007, treatment 25 of 46 (54.3%), control 36 of 44 (81.8%), NNT 3.6, >14 days.
ICU stay, 6.6% lower, RR 0.93, p = 0.43, treatment 41 of 46 (89.1%), control 42 of 44 (95.5%), NNT 16, >7 days.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Faruq et al., 1 Sep 2023, Randomized Controlled Trial, Bangladesh, peer-reviewed, 4 authors.
This PaperNigella SativaAll
Mohammad Omar Faruq, Karishma Shamarukh, Samira Humaira Habib, Amina Sultana, Umme Kulsum Chy, Chowdhury Tasneem Hasin, Mohammed Salah Uddin, Samira Humaira Habib, Susmita Hossain, Yasmin Tamanna, Shena, Tasmia Kashfi, Md Gisan Hossain, Md Rashedul Haque Khan, Razibul Hasan, MD Saifuddin Sujhon, Mehnaz Ferdous, Syed Mahfuzur Rahman, Ahmed Sayeed Arefin, Mir Atiqur Rahman, Shamsi Islam
The user has requested enhancement of the
Conflict of interest: None. Funding: Self-funded. Author contribution:
Anwar, Hussain, Zengin, A plant with high potential for development of functional foods and nutraceuticals/ pharmaceuticals, International Journal of Pharmacology
Ashraf, Ashraf, Imran, Kalsoom, Siddiqui et al., Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial, doi:10.1101/2020.10.30.20217364
Azeiz, Darweesh, Amin, Efficacy of thymoquinone against vaginal candidiasis in prednisolone-induced immunesuppressed mice, J Am Sci
Barakat, Wakeel, Hagag, Effects of Nigella sativa on outcome of hepatitis C in Egypt, World J Gastroenterol
Bouchentouf, Missoum, Identification of Compounds from Nigella Sativaas New Potential Inhibitors of 2019 Novel Coronavirus (Covid-19): Molecular Docking Study, ChemRxiv, doi:10.26434/chemrxiv.12055716.v1
Carsana, Sonzognia, Naser, Pulmonary post mortem findings in a series of COVID -19 cases from northern Italy: a two center descriptive study, Lancet infect Dis
Chaieb, Kouidhi, Jrah, Mahdouani, Bakhrouf, Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation, BMC Complement Altern Med
Dietician, None
Elgazzar, Elmezayen, Marecki, Nicolls, Canastar et al., Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation, Int Immunopharmacol
Faiq, Ghareeb, Clinical trials of black seeds against COVID -`19 in Kirkuk city on Iraq, Ind. J. O Forens. Med. and Toxicology
Forouzanfar, Bazzaz, Hosseinzadeh, Black cumin (Nigella Sativa) and its constituent (thymoquinone): a review on antimicrobial effects, Iran J Basic Med Sci
Gali-Muhtasib, Ocker, Kuester, Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models, J Cell Mol Med
Goreja, Black seed: nature's miracle remedy
Guan, Ni, Hu, Clinical Characteristics of Corona virus Disease 2019 in China, N Engl J Med, doi:10.1056/NEJMoa2002032
Halawani, Anti-bacterial activity of thymo-quinone and thymohydroquin one of Nigella sativa L. and their interaction with some antibiotics, Adv Biol Res
Haq, Abdullatif, Lobo, Khabar, Sheth et al., Nigella Sativa: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity, Immunopharmacology
Haq, Lobo, Al-Tufail, Rama, St, Immunomodulatory effect of Nigella sativa proteins fractionated by ionex change chromatography, Int J Immunopharmacol
Hassanien, Assiri, Alzohairy, Oraby, Health-promoting value and food applications of black cumin essential oil: an overview, J Food Sci Technol
Hosseinzadeh, Pervade, Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice, Phytomedicine
Hosseinzadeh, Taiari, Nassiri-Asl, Effect of thymoquinone, a constituent of Nigella sativa L. on ischemia-reperfusion in rat skeletal muscle, Naunyn Schmiedebergs Arch Pharmacol
Huang, Wangy, Lix, Renl, Zhaoj et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Khan, Chemical composition and medicinal properties of Nigella sativa Linn, Inflammo-pharmacology
Koshak, Koshak, Mobeireek, Badawima, Wali et al., Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial, Complementary Therapies in Medicine
Onifade, Jewell, Adedeji, Nigella sativa concoction induced sustained seroreversion in HIV patient, Afr J Tradit Complement Altern Med
Ralph, Lew, Zeng, Francis, Xue et al., -CoV (Wuhanvirus), a novel Corona virus: human-to-human transmission, travel-related cases, and vaccine readiness, J Infect Dev Ctries
Ramadan, Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview, International Journal of Food Science & Technology
Said, Abdulbaset, El-Kholy, Besckales, Sabri, The effect of Nigella Sativa and Vitamin D3 supplementation on clinicasl outcome in COVID -19 patients: A randomized controlled clinical trial, Front Phamacol, doi:10.3389/fphar2022.1011522
Salem, Hossain, Protective effect of black seed oil from Nigella sativa against murine cytomegalo virus infection, Int J Immunopharmacol
Umar, Shah, Munir, Yaqoob, Fiaz et al., Synergistic effects of thymoquinone and curcumin on immune response and anti-viral activity against avain influenza virus (H9N2) in turkeys, Poult Sci
Who Director, General's opening remarks at the media brief in gon COVID-19-11
Yang, Yu, Xu, Shu, Xia et al., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China:a single-centered, retrospective, observational study, Lancet Resp Med
Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop