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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 6% Improvement Relative Risk Ventilation, day 14 62% Ventilation, day 7 83% ICU stay, >28 days 23% ICU stay, >21 days 28% ICU stay, >14 days 34% ICU stay, >7 days 7% Nigella Sativa  Faruq et al.  ICU PATIENTS  RCT Is very late treatment with nigella sativa beneficial for COVID-19? RCT 150 patients in Bangladesh Lower ventilation with nigella sativa (p=0.012) c19early.org Faruq et al., Bangladesh Critical Care.., Sep 2023 Favors nigella sativa Favors control

Role of Nigella Sativa (black cumin seeds)as an adjunct therapy in treating severe and critical COVID -19 infection compared to those with standard therapy : An open label randomized clinical trial

Faruq et al., Bangladesh Critical Care Journal, doi:10.3329/bccj.v11i2.69187
Sep 2023  
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11th treatment shown to reduce risk in January 2021
 
*, now known with p = 0.00016 from 14 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Open label randomized trial of 150 ICU patients in Bangladesh, showing shorter ICU stay and lower requirements for increased oxygen support including mechanical ventilation with nigella sativa treatment, but no significant difference in mortality.
The large baseline difference in convalescent plasma usage suggests an error or randomization problem.
This study is excluded in the after exclusion results of meta analysis: potential data issue.
risk of death, 6.5% lower, RR 0.94, p = 0.87, treatment 29 of 75 (38.7%), control 31 of 75 (41.3%), NNT 37.
risk of mechanical ventilation, 61.9% lower, RR 0.38, p = 0.01, treatment 8 of 75 (10.7%), control 21 of 75 (28.0%), NNT 5.8, day 14.
risk of mechanical ventilation, 83.3% lower, RR 0.17, p < 0.001, treatment 3 of 75 (4.0%), control 18 of 75 (24.0%), NNT 5.0, day 7.
ICU stay, 23.5% lower, RR 0.77, p = 0.74, treatment 4 of 46 (8.7%), control 5 of 44 (11.4%), NNT 37, >28 days.
ICU stay, 28.3% lower, RR 0.72, p = 0.46, treatment 9 of 46 (19.6%), control 12 of 44 (27.3%), NNT 13, >21 days.
ICU stay, 33.6% lower, RR 0.66, p = 0.007, treatment 25 of 46 (54.3%), control 36 of 44 (81.8%), NNT 3.6, >14 days.
ICU stay, 6.6% lower, RR 0.93, p = 0.43, treatment 41 of 46 (89.1%), control 42 of 44 (95.5%), NNT 16, >7 days.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Faruq et al., 1 Sep 2023, Randomized Controlled Trial, Bangladesh, peer-reviewed, 4 authors.
This PaperNigella SativaAll
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Mohammad Omar Faruq, Karishma Shamarukh, Samira Humaira Habib, Amina Sultana, Umme Kulsum Chy, Chowdhury Tasneem Hasin, Mohammed Salah Uddin, Samira Humaira Habib, Susmita Hossain, Yasmin Tamanna, Shena, Tasmia Kashfi, Md Gisan Hossain, Md Rashedul Haque Khan, Razibul Hasan, MD Saifuddin Sujhon, Mehnaz Ferdous, Syed Mahfuzur Rahman, Ahmed Sayeed Arefin, Mir Atiqur Rahman, Shamsi Islam
doi:10.3329/bccj.v11i2.69187
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Conflict of interest: None. Funding: Self-funded. Author contribution:
References
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Late treatment
is less effective
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