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Assessment Of The Efficacy Of Spironolactone For COVID-19 ARDS Patients

Ersoy et al., Aydin Sağlik Dergi̇si̇, doi:10.17932/IAU.ASD.2015.007/asd_v07i3002
Oct 2021  
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Mortality 46% Improvement Relative Risk Spironolactone  Ersoy et al.  ICU PATIENTS Is very late treatment with antiandrogens beneficial for COVID-19? Retrospective 60 patients in Turkey Lower mortality with antiandrogens (p=0.0022) Ersoy et al., Aydin Sağlik Dergi̇si̇, Oct 2021 Favorsspironolactone Favorscontrol 0 0.5 1 1.5 2+
7th treatment shown to reduce risk in September 2020
*, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments.
Retrospective 30 COVID-19 ARDS ICU patients and 30 control patients, showing lower mortality with treatment.
risk of death, 46.2% lower, RR 0.54, p = 0.002, treatment 14 of 30 (46.7%), control 26 of 30 (86.7%), NNT 2.5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ersoy et al., 13 Oct 2021, retrospective, Turkey, peer-reviewed, 7 authors.
This PaperAntiandrogensAll
Covid19 ARDS olgularında spironolaktonun etkinliğinin değerlendirilmesi Assessment Of The Efficacy Of Spironolactone For COVID-19 ARDS Patients
Aysin Ersoy, Bülent Barış Güven, Tuna Ertürk, Fulya Yurtseven, Zöhre Karaman, Temel Güner, Özge Kömpe
AYDIN SAĞLIK DERGİSİ, doi:10.17932/iau.asd.2015.007/asd_v07i3002
The aim of our study is to compare patients monitored for ARDS diagnosis linked to COVID-19 treated with spironolactone with patients who did not use spironolactone and to retrospectively identify whether there was any positive effect on mortality using clinical and laboratory data from patients. MATERIAL AND METHOD Two groups were created of patients treated due to severe ARDS diagnosis linked to COVID-19. One group administered spironolactone (Group S, n=30) and the other group was not (Group F, n=30). Groups were compared in terms of demographic characteristics, presence of comorbidity, inotropic agent requirements, (intensive care unit) ICU length of stay', days of mechanical ventilation and mortality. Additionally, fever, PO2/FIO2 (Horowitz ratio), lymphocyte count, CRP value, SOFA scorer, and d-dimer levels on the ICU length of stay, 1st day, 3rd day, 5th day, 8th day, 12th day, day of discharge or day of exitus were compared between the groups and statistically analyzed. RESULTS Group S was found to have a higher ICU length of stay and days of mechanical ventilation compared to Group F. (p<0.05). Group F had significantly a higher mortality rate compared to Group S. (p<0.05). The final Horowitz value in Group F was found to be significantly lower compared to Group S. (p<0.05). The lymphocyte values in Group F were significantly lower than Group S on the 1st, 3rd, 5th, 8th and 12th day and at the final measurement. (p<0.05). The CRP values in Group F were significantly higher than Group S on the 3rd, 5th, 8th and 12th day and at the final measurement. (p<0.05). The SOFA scores on the 8th and 12th days and at the final measurement in Group F were found to be significantly higher than GroupS. (p<0.05). CONCLUSION In our study, parameters for disease severity regressed, patients survived for longer and mortality was identified to be lower in the group using spironolactone.
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Late treatment
is less effective
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