Turning up the heat on COVID-19: heat as a therapeutic intervention
Marc Cohen, Elizabeth A Repasky, Jari Laukkanen
F1000Research, doi:10.12688/f1000research.23299.1
Enveloped viruses such as SAR-CoV-2 are sensitive to heat and are destroyed by temperatures tolerable to humans. All mammals use fever to deal with infections and heat has been used throughout human history in the form of hot springs, saunas, hammams, steamrooms, sweat-lodges, steam inhalations, hot mud and poultices to prevent and treat respiratory infections and enhance health and wellbeing. This paper reviews the evidence for using heat to treat and prevent viral infections and discusses potential cellular, physiological and psychological mechanisms of action. In the initial phase of infection, heat applied to the upper airways can support the immune system's first line of defence by supporting muco-ciliary clearance and inhibiting or deactivating virions where they first lodge. This may be further enhanced by the inhalation of steam containing essential oils with anti-viral, mucolytic and anxiolytic properties. Heat applied to the whole body can further support the immune system's second line of defence by mimicking fever and activating innate and acquired immune defences and building physiological resilience. Heat-based treatments also offer psychological benefits and enhanced mental wellness by focusing attention on positive action, enhancing relaxation and sleep, inducing 'forced-mindfulness', and invoking the power of positive thinking and 'remembered wellness'. Heat is a cheap, convenient and widely accessible therapeutic modality and while no clinical protocols exist for using heat to treat COVID-19, protocols that draw from traditional practices and consider contraindications, adverse effects and infection control measures could be developed and implemented rapidly and inexpensively on a wide scale. While there are significant challenges in implementing heat-based therapies during the current pandemic, these therapies present an opportunity to integrate natural medicine, conventional medicine and traditional wellness practices, and support the wellbeing of both patients and medical staff, while building community resilience and reducing the likelihood and impact of future pandemics.
Author Response 12 Jul 2020
Marc Cohen I agree that this is a timely and interesting topic that covers a wide range of literature and am grateful for your comments, which have led to improvements in the paper's content and flow. I have now modified the wording to better reflect the difference between fever and externally applied heat stress and have referenced a review of the different forms of heat treatment that are currently being used or are under investigation for cancer therapy and suggest they may be useful for treating COVID-19. I have also added more detail on the adverse effects of heat and have reorganised some sections to improve the flow of information and make the paper more cohesive. Competing Interests: All competing interests have been declared in the authorship statement.
Comments on this article
References
Ali, Wabel, Shams, Essential oils used in aromatherapy: A systemic review, Asian Pac J Trop Biomed
Benson, Friedman, Harnessing the power of the placebo effect and renaming it "remembered wellness, Annu Rev Med
Heinonen, Laukkanen, Effects of heat and cold on health, with special reference to Finnish sauna bathing, Am J Physiol Regul Integr Comp Physiol,
doi:10.1152/ajpregu.00115.2017
Heinonen, Laukkanen, Effects of heat and cold on health, with special reference to Finnish sauna bathing, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology,
doi:10.1152/ajpregu.00115.2017
Hu, Trefethen, Zeng, Biophysical characterization and conformational stability of Ebola and Marburg virus-like particles, J Pharm Sci,
doi:10.1002/jps.22724
Hussain, Cohen, Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review, Evid Based Complement Alternat Med,
doi:10.1155/2018/1857413
Irwin, Opp, Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity, Neuropsychopharmacology,
doi:10.1038/npp.2016.148
Kappel, Stadeager, Tvede, Effects of in vivo hyperthermia on natural killer cell activity, in vitro proliferative responses and blood mononuclear cell subpopulations, Clin Exp Immunol,
doi:10.1111/j.1365-2249.1991.tb08144.x
Kudo, Song, Yockey, Low ambient humidity impairs barrier function and innate resistance against influenza infection, Proc Natl Acad Sci,
doi:10.1073/pnas.1902840116
Kunutsor, Laukkanen, Laukkanen, Frequent sauna bathing may reduce the risk of pneumonia in middle-aged Caucasian men: The KIHD prospective cohort study, Respir Med,
doi:10.1016/j.rmed.2017.10.018
Kunutsor, Laukkanen, Laukkanen, Longitudinal associations of sauna bathing with inflammation and oxidative stress: the KIHD prospective cohort study, Ann Med,
doi:10.1080/07853890.2018.1489143
Kunutsor, Laukkanen, Laukkanen, Longitudinal associations of sauna bathing with inflammation and oxidative stress: the KIHD prospective cohort study, Ann Med,
doi:10.1080/07853890.2018.1489143
Kunutsor, Laukkanen, Laukkanen, Sauna bathing reduces the risk of respiratory diseases: a long-term prospective cohort study, Eur J Epidemiol,
doi:10.1007/s10654-017-0311-6
Kunutsor, Laukkanen, Laukkanen, Sauna bathing reduces the risk of respiratory diseases: a long-term prospective cohort study, European Journal of Epidemiology,
doi:10.1007/s10654-017-0311-6
Laitinen, Lindqvist, Heino, Effect of pH and temperature on the infectivity of human coronavirus 229E, Can J Microbiol,
doi:10.1139/m89-160
Laukkanen, Khan, Zaccardi, Laukkanen, Association between sauna bathing and fatal cardiovascular and all-cause mortality events, JAMA Intern Med,
doi:10.1001/jamainternmed.2014.8187
Laukkanen, Kunutsor, Is sauna bathing protective of sudden cardiac death? A review of the evidence, Prog Cardiovasc Dis,
doi:10.1016/j.pcad.2019.05.001
Laukkanen, Kunutsor, Is sauna bathing protective of sudden cardiac death? A review of the evidence, Prog Cardiovasc Dis,
doi:10.1016/j.pcad.2019.05.001
Laukkanen, Laukkanen, Kunutsor, Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence, Mayo Clin Proc,
doi:10.1016/j.mayocp.2018.04.008
Laukkanen, Laukkanen, Kunutsor, Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence, Mayo Clin Proc,
doi:10.1016/j.mayocp.2018.04.008
Lelie, Reesink, Lucas, Inactivation of 12 viruses by heating steps applied during manufacture of a hepatitis B vaccine, J Med Virol,
doi:10.1002/jmv.1890230313
Mace, Zhong, Kilpatrick, Differentiation of CD8+ T cells into effector cells is enhanced by physiological range hyperthermia, J Leukoc Biol,
doi:10.1189/jlb.0511229
Mk, Lim, Song, The effects of aromatherapy essential oil inhalation on stress, sleep quality and immunity in healthy adults: Randomized controlled trial, Eur J Integr Med,
doi:10.1016/j.eujim.2017.04.009
Mäkinen, Juvonen, Jokelainen, Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections, Respir Med,
doi:10.1016/j.rmed.2008.09.011
Pilch, Pokora, Szyguła, Effect of a single finnish sauna session on white blood cell profile and cortisol levels in athletes and non-athletes, J Hum Kinet,
doi:10.2478/hukin-2013-0075
Sajadi, Habibzadeh, Vintzeleos, Reference Source Schieber AMP, Ayres JS: Thermoregulation as a disease tolerance defense strategy, Pathog Dis,
doi:10.1093/femspd/ftw106
Shemilt, Bagabir, Lang, Potential mechanisms for the effects of farinfrared on the cardiovascular system -a review, Vasa,
doi:10.1024/0301-1526/a000752
Sobajima, Nozawa, Ihori, Repeated Low-Temperature Sauna Therapy Improves Cardiac and Exercise Capacity as well as Immune Competence in Patients with Heart Failure, Circulation,
doi:10.1161/circ.126.suppl_21.a10868
Sturman, Ricard, Holmes, Conformational change of the coronavirus peplomer glycoprotein at pH 8.0 and 37 degrees C correlates with virus aggregation and virus-induced cell fusion, J Virol,
doi:10.1128/JVI.64.6.3042-3050.1990
Tomiyama, Watanabe, Honma, The effect of repetitive mild hyperthermia on body temperature, the autonomic nervous system, and innate and adaptive immunity, Biomed Res,
doi:10.2220/biomedres.36.135
Tsuchiya, Shimizu, Tazawa, Effects of hot deep seawater bathing on the immune cell distribution in peripheral blood from healthy young men, Environ Health Prev Med,
doi:10.1007/BF02897909
Wang, Crisis and Opportunities for the Chinese Hot Springs Industry in Year 2020
Wang, Tang, Feng, High Temperature and High Humidity Reduce the Transmission of COVID-19
Zellner, Hergovics, Roth, Human monocyte stimulation by experimental whole body hyperthermia, Wien Klin Wochenschr